口腔疾病防治 ›› 2021, Vol. 29 ›› Issue (6): 383-387.doi: 10.12016/j.issn.2096-1456.2021.06.004

• 基础研究 • 上一篇    下一篇

Bex1和NF-kBp65在舌鳞状细胞癌组织中的表达及意义

王倩倩1(),丁丹丹1,丁翔2,韩瑞1,韩影影1,周美云1,徐锦程1()   

  1. 1.蚌埠医学院第一附属医院口腔科,安徽 蚌埠(233004)
    2.蚌埠医学院第二附属医院口腔科,安徽 蚌埠(233000)
  • 收稿日期:2020-11-04 修回日期:2020-12-23 出版日期:2021-06-20 发布日期:2021-04-12
  • 通讯作者: 徐锦程 E-mail:1962580034@qq.com;xjch9999@163.com
  • 作者简介:王倩倩,医师,硕士,Email: 1962580034@qq.com
  • 基金资助:
    安徽省高校自然科学研究重点项目(KJ2016A480)

Expression of Bex1 and NF-kBp65 in tongue squamous cell carcinoma and its significance

WANG Qianqian1(),DING Dandan1,DING Xiang2,HAN Rui1,HAN Yingying1,ZHOU Meiyun1,XU Jincheng1()   

  1. 1. Department of Stomatology, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
    2. Department of Stomatology, the Second Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China
  • Received:2020-11-04 Revised:2020-12-23 Online:2021-06-20 Published:2021-04-12
  • Contact: Jincheng XU E-mail:1962580034@qq.com;xjch9999@163.com
  • Supported by:
    grants from Key Project of Natural Science Research in Anhui Province(KJ2016A480)

摘要:

目的 探讨Bex1和NF-kBp65在舌鳞状细胞癌组织中的表达及意义。方法 免疫组化法检测60例舌鳞状细胞癌组织及相应癌旁正常组织中Bex1和NF-kBp65的表达情况,分析其与患者临床病理特征及预后的关系。结果 舌鳞状细胞癌组织中Bex1阳性表达率为48.3%(29/60),低于癌旁正常组织的88.3%(53/60),差异有统计学意义(x2=22.18,P<0.01),其阳性表达率与TNM分期呈负相关(P < 0.05);舌鳞状细胞癌组织中NF-kBp65阳性表达率63.3%(38/60),高于癌旁正常组织的20%(12/60),差异有统计学意义(x2=23.18,P<0.01),其阳性表达率与肿瘤TNM分期呈正相关(P < 0.05)。Pearson相关性分析显示,Bex1和NF-kBp65的表达呈负相关(r=-0.302,P=0.019)。Kaplan-Meier生存曲线显示,Bex1阳性表达患者的生存率明显高于阴性表达患者。结论 舌鳞状细胞癌组织中,Bex1阳性表达率低和NF-kBp65阳性表达率高可能对肿瘤的侵袭和转移起促进作用,且Bex1阴性表达可能与患者不良预后有关。

关键词: 舌肿瘤; 鳞状细胞癌; 侵袭; 转移; TNM分期; Bex1; NF-kBp65; 免疫组化; 预后

Abstract:

Objective To investigate the expression of brain expressed X-linked gene 1(Bex1) and nuclear factor-kBp65 (NF-kBp65) in tongue squamous cell carcinoma, and its significance. Methods Immunohistochemistry was used to detect the expression of Bex1 and NF-kBp65 in 60 tongue squamous cell carcinoma (TSCC) tissues and adjacent normal tissues, and the relationships between Bex1, NF-kBp65 and the clinicopathological features and prognosis of patients were analyzed. Results The positive expression rate of Bex1 in TSCC was 48.3% (29/60), which was significantly lower than that in adjacent normal tissues 88.3% (53/60) (x2=22.18, P < 0.01). The positive rate of Bex1 was negatively correlated with TNM stage, and the difference was statistically significant (P < 0.05). The positive rate of 63.3% (38/60) in TSCC was significantly higher than 20% (12/60) in adjacent normal tissues (x2=23.18, P < 0.01), the positive rate of NF-kBp65 was positively correlated with TNM stage, and the difference was statistically significant (P < 0.05). According to the Pearson correlation analysis results, the expression of Bex1 and NF-kBp65 in TSCC tissues was negatively correlated (r=-0.302, P=0.019). Kaplan-Meier survival curves showed that the survival rate of Bex1 positive patients was significantly higher than that of Bex1 negative patients. Conclusion In TSCC tissues, the low positive expression rate of Bex1 and the high positive expression rate of NF-kBp65 may promote tumor invasion and metastasis, and the negative expression of Bex1 may be related to the poor prognosis of patients.

Key words: tongue neoplasms; squamous cell carcinoma; invasion; metastasis; TNM stage; Bex1; NF-kBp65; immunohistochemistry; prognosis

中图分类号: 

  • R78