Advances in research on the prevention and treatment of dental erosion b y MMPs inhibitors

doi:10.12016/j.issn.2096-1456.2017.12.013

Abstract

Abstract:

High prevalence of dental erosion has been reported in recent years. The prevention and treatment of dental erosion has therefore attracted lots of attention in dentistry. Matrix metalloproteinases (MMPs) is a type of proteolytic enzyme containing Zn²⁺ and Ca²⁺, which can degrade organic matrix in advanced dental erosion. MMPs inhibitors were reported to have the potential to prevent the organic matrix of dentin from degradation, which might provide protective capacity against dental erosion. The present article reviews the mechanism and potential application of MMPs inhibitors in the prevention and treatment of dental erosion.

Key words: Dental erosion, Dentin, Prevention, Therapy, MMPs, MMPs inhibitors

摘要：

近年来牙酸蚀症的患病率不断上升,预防及治疗牙酸蚀症已成为口腔医学的热点问题。基质金属蛋白酶（Matrix metalloproteinases,MMPs）是一类含Zn²⁺和Ca²⁺的蛋白水解酶,是牙酸蚀症发病过程中降解牙本质有机基质的主要蛋白水解酶之一。近年来有学者提出应用MMPs抑制剂以阻断牙本质有机基质的降解从而达到预防和治疗牙酸蚀症的目的。本文对MMPs抑制剂的作用机理及其用于牙酸蚀症预防和治疗的可行性作一综述,为相关临床及科研工作提供策略。

关键词: 酸蚀, 牙本质, 预防, 治疗, 基质金属蛋白酶, 基质金属蛋白酶抑制剂

CLC Number:

R781.2

Nengwu JIANG, Hao YU. Advances in research on the prevention and treatment of dental erosion b y MMPs inhibitors[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(12): 810-813.

蒋能舞, 于皓. 基质金属蛋白酶抑制剂防治牙酸蚀症的研究进展[J]. 口腔疾病防治, 2017, 25(12): 810-813.

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