Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (5): 281-287.doi: 10.12016/j.issn.2096-1456.2018.05.002

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The relationship between orthodontic treatment and periodontitis: an analysis from clinical trials to biological experiments

Yanqi YANG1(), Minjie LI1,2   

  1. 1. Department of Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region 999077, China
    2. Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
  • Received:2017-11-04 Revised:2017-12-27 Online:2018-05-20 Published:2018-08-30

Abstract:

Increasing numbers of adult patients are seeking orthodontic treatment, which increases the need for orthodontists to treat malocclusion in periodontally compromised teeth affected by periodontitis. It is essential to control active inflammation prior to initiating an orthodontic protocol to avoid further breakdown of alveolar bone caused by periodontitis. However, whether the condition of periodontal ligaments can completely recover to a normal condition after controlling inflammation and tolerate orthodontic tooth movement remains controversial. The present review elaborates, from clinical trials (macroscopic) to biological tests (microscopic), the characteristics of periodontal tissue and periodontal ligament cells with a history of periodontitis that are submitted to orthodontic force loading. The following conclusions are made: 1. Orthodontic treatment in periodontally compromised patients is unusual because of changes in periodontal condition. 2. The combination of orthodontic force loading and uncontrolled periodontal inflammation aggravates pathological bone resorption; therefore, it is crucial to perform periodontal therapy prior to orthodontic treatment. 3. The periodontal ligament can withstand proper mechanical force loading after periodontal treatment. 4. Orthodontic treatment, as an adjunctive therapy, can improve periodontally compromised tissue and pathological tooth movement.

Key words: Adult orthodontic treatment, Periodontitis, Periodontal ligament, Inflammation control, Biological response

CLC Number: 

  • R781.4

Figure 1

Images of typical case 1 of pre- and post- orthodontic treatment of periodontally compromised teeth"

Figure 2

Images of typical case 2 of pre- and post- orthodontic treatment of periodontally compromised teeth"

Figure 3

Biological characteristics of PDLCs"

[1] Hägg U, Corbet EF, Rabie AM.Adult orthodontics and its interface with other disciplines[J]. Hong Kong Med J, 1996, 2(2): 186-190.
[2] Rabie AM, Yang Y.Perio-ortho conjoint treatment of periodontally compromised patients[J]. Chin J Orthod, 2009, 16(4): 181-183.
[3] Zainal Ariffin SH, Yamamoto Z, Zainol Abidin IZ, et al.Cellular and molecular changes in orthodontic tooth movement[J]. Scientific World Journal, 2011, 11(3): 1788-1803.
[4] Lekic P, McCulloch CA. Periodontal ligament cell population: the central role of fibroblasts in creating a unique tissue[J]. Anat Rec, 1996, 245(2): 327-341.
[5] Ong MA, Wang HL, Smith FN.Interrelationship between periodontics and adult orthodontics[J]. J Clin Periodontol, 1998, 25(4): 271-277.
[6] Suzuki R, Nemoto E, Shimauchi H.Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells[J]. Exp Cell Res, 2014, 323(1): 232-241.
[7] Si LE, Park KH, Kim SJ, et al.Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells[J]. Clin Exp Immunol, 2012, 168(1): 113-124.
[8] Kapoor P, Kharbanda OP, Monga N, et al.Effect of orthodontic forces on cytokine and receptor levels in gingival crevicular fluid: a systematic review[J]. Prog Orthod, 2014, 15(65): 1-21.
[9] Hienz SA, Paliwal S, Ivanovski S.Mechanisms of bone resorption in periodontitis[J]. J Immunol Res, 2015, 2015: 615486.
[10] Boas NA, Souza JD, Kim YJ, et al.Orthodontic force increases interleukin-1beta and tumor necrosis factor-alpha expression and alveolar bone loss in periodontitis[J]. J Periodontol, 2013, 84(9): 1319-1326.
[11] Kirschneck C, Fanghänel J, Wahlmann U, et al.Interactive effects of periodontitis and orthodontic tooth movement on dental root resorption, tooth movement velocity and alveolar bone loss in a rat model[J]. Ann Anat, 2017, 210: 32-43.
[12] Li M, Zhang C, Jin L, et al.Porphyromonas gingivalis lipopolysaccharide regulates ephrin/Eph signalling in human periodontal ligament fibroblasts[J]. J Periodontal Res, 2017, 52(5): 913-921.
[13] Nogueira AV, Nokhbehsaim M, Eick S, et al.Biomechanical loading modulates proinflammatory and bone resorptive mediators in bacterial-stimulated PDL cells[J]. Mediators Inflamm, 2014: 425421.
[14] Tsuji K, Uno K, Zhang GX, et al.Periodontal ligament cells under intermittent tensile stress regulate mRNA expression of osteoprotegerin and tissue inhibitor of matrix metalloprotease-1 and -2[J]. J Bone Miner Metab, 2004, 22(2): 94-103.
[15] Roemer P, Koestler J, Koretsi V, et al.Endotoxins potentiate COX-2 and RANKL expression in compressed PDL cells[J]. Clin Oral Investig, 2013, 17(9): 2041-2048.
[16] Proff P, Reicheneder C, Faltermeier AA, et al.Effects of mechanical and bacterial stressors on cytokine and growth-factor expression in periodontal ligament cells[J]. J Orofac Orthop, 2014, 75(3): 191-202.
[17] Deas DE, Mealey BL.Response of chronic and aggressive periodontitis to treatment[J]. Periodontol 2000, 2010, 53(1):154-166.
[18] Saglam M, Kantarci A, Dundar N, et al.Clinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis: a randomized, controlled clinical trial[J]. Lasers Med Sci, 2014, 29(1): 37-46.
[19] Pesevska S, Gjorgoski I, Ivanovski K, et al.The effect of low-level diode laser on COX-2 gene expression in chronic periodontitis patients[J]. Lasers Med Sci, 2017, 32(7): 1463-1468.
[20] Mcculloch C.Host enzymes in gingival crevicular fluid as diagnostic indicators of periodontitis[J]. J ClinPeriodontol, 1994, 21(7): 497-506.
[21] Romano F, Bongiovanni L, Bianco L, et al.Biomarker levels in gingival crevicular fluid of generalized aggressive periodontitis patients after non-surgical periodontal treatment[J]. Clin Oral Investig, 2018, 22(2): 1083-1092.
[22] Branco-De-Almeida LS, Cruz-Almeida Y, Gonzalez-Marrero Y, et al. Local and plasma biomarker profiles in localized aggressive periodontitis[J]. JDR Clin Trans Res, 2017, 2(3): 258-268.
[23] De Lima OA, Faveri MD, Gursky LC, et al.Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects[J]. J Clin Periodontol, 2012, 39(3): 295-302.
[24] Kinney JS, Morelli T, Oh M, et al.Crevicular fluid biomarkers and periodontal disease progression[J]. J Clin Periodontol, 2014, 41(2): 113-120.
[25] Lim WB, Choi H, Kim J, et al.Anti-inflammatory effect of 635 nm irradiations on in vitro direct/indirect irradiation model[J]. J Oral Pathol Med, 2015, 44(2): 94-102.
[26] Theodoro LH, Longo M, Noronha Novaes VC, et al.Low-level laser and antimicrobial photodynamic therapy on experimental periodontitis in rats submitted to chemotherapy by 5-fluorouracil[J]. Supportive Care in Cancer, 2017, 25(10): 3261-3271.
[27] Gkantidis N, Christou P, Topouzelis N.The orthodontic-periodontic interrelationship in integrated treatment challenges: a systematic review[J]. J Oral Rehabil, 2010, 37(5): 377-390.
[28] Re S, Corrente G, Abundo R, et al.Orthodontic treatment in periodontally compromised patients: 12-year report[J]. Int J Periodontics Restorative Dent, 2000, 20(1): 31-39.
[29] Puttaravuttiporn P, Wongsuwanlert M, Charoemratrote C, et al.Effect of incisal loading during orthodontic treatment in adults: a randomized control trial[J]. Angle Orthod, 2017, 88(1):35-44.
[30] Almeida Rc JC, Teles RP.Levels of gingival crevicular fluid matrix metalloproteinases in periodontally compromised teeth under orthodontic forces[J]. Angle Orthod, 2015, 85(6): 1009-1014.
[31] Teles R, Sakellari D, Teles F, et al.Relationships among gingival crevicular fluid biomarkers, clinical parameters of periodontal disease, and the subgingival microbiota[J]. J Periodontol, 2010, 81(1): 89-98.
[32] Zhang J, Zhang AM, Zhang ZM, et al.Efficacy of combined orthodontic-periodontic treatment for patients with periodontitis and its effect on inflammatory cytokines: a comparative study[J]. Am J Orthod Dentofacial Orthop, 2017, 152(4): 494-500.
[33] Sokos D, Everts V, de Vries TJ. Role of periodontal ligament fibroblasts in osteoclastogenesis: a review[J]. J Periodontal Res, 2015, 50(2): 152-159.
[34] Basdra EK, Komposch G.Osteoblast-like properties of human periodontal ligament cells: an in vitro analysis[J]. Eur J Orthod, 1997, 19(6): 615-621.
[35] Cardaropoli D, Gaveglio L, Ramzi V, et al.Orthodontic movement and periodontal bone defects: rationale, timing, and clinical implications[J]. Semin Orthod, 2014, 20(3): 177-187.
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