Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (3): 202-204.doi: 10.12016/j.issn.2096-1456.2019.03.012

• Review Articles • Previous Articles    

Research progress of IL-33/ST2 signaling pathway in bone metabolism

ZHU Yanxia,Gegen tana()   

  1. Department of Stomatology, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region Hohhot 010000, China
  • Received:2018-05-15 Revised:2018-11-02 Online:2019-03-20 Published:2019-03-20
  • Contact: tana Gegen E-mail:nmggtana@qq.com

Abstract:

Interleukin-33(IL-33) is a new member of the interleukin-1 (IL-1) cytokine superfamily. It can activate mast cells, lymphocytes and macrophages to produce Th2 cytokines and plays a very important role in inflammation, infection, and autoimmune disease. The classical signal pathway of IL-33 includes the isotrimer of ST2 and interleukin-1 receptor accessory protein (IL-1 RAcP), which transduces signals into cells. The IL-33/ST2 signaling pathway affects bone metabolism by activating T and B lymphocytes. This article reviews the role of the IL-33/ST2 signaling pathway in bone metabolism. The results of a literature review showed that at present, scholars at home and abroad still dispute the role of IL-33 in bone metabolism. Some scholars believe that IL-33 can inhibit osteoclast formation, and IL-33 has been recently implicated in physiological bone remodeling. However, other scholars believe that IL-33 can promote osteoclast formation and differentiation, which leads to bone absorption. IL-33 and its signaling pathway are involved in bone metabolism of alveolar bone in periodontitis and periapical periodontitis. The specific mechanism remains unclear, and further studies are warranted.

Key words: IL-33, ST2, Osteoclast, Osteoblast, Bone metabolism, Interleukin-1 receptor accessory protein, Periodontitis, Periapical periodontitis

CLC Number: 

  • R781.05
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