Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (8): 506-509.doi: 10.12016/j.issn.2096-1456.2020.08.005

• Cinical Study • Previous Articles     Next Articles

Serum levels of iron, zinc, copper and vitamin D in severe early childhood caries

ZHU Shaojun1,RENA· Maimaiti2,ZHANG Bei1,WANG Zhiheng1,GE Jinlian3,LIU Yishan1()   

  1. 1. Department of Pediatric and Preventive Dentistry, The First Affiliated Hospital of Xinjiang Medical University(Affiliated Stomatological Hospital), Urumqi 830054, China
    2. The Child Health Department of the Xinjiang Medical University Health Management Center, Urumqi 830054, China
    3. Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
  • Received:2019-11-11 Revised:2020-02-11 Online:2020-08-20 Published:2020-07-15
  • Contact: Yishan LIU E-mail:lys-tree@126.com

Abstract:

Objective The serum levels of iron, zinc, copper and vitamin D in severe early childhood caries (S-ECC) patients were investigated and analyzed to provide reference for primary prevention and diagnosis of S-ECC children. Methods A total of 184 children were enrolled in the Children Health Department of Xinjiang Medical University Health Management Center from June 2018 to June 2019. They were divided into the caries-free (CF) group (n=89) and S-ECC group (n=95). The contents of iron, zinc, copper and vitamin D were detected. Results The serum iron content of the CF group and S-ECC group was (8.36 ± 0.42) mmol/L and (8.13 ± 0.44) mmol/L, respectively, and the difference was statistically significant (t=3.50, P < 0.001); the serum content of zinc was (83.18 ± 7.28) μmol/L and (79.23 ± 6.38) μmol/L, respectively, and the difference was statistically significant (t=3.92, P < 0.001); the serum content of 25-hydroxyvitamin D was (86.72 ± 15.83) nmol/L and (77.75 ± 11.38) nmol/L, respectively, and the difference was statistically significant (t=4.42, P < 0.001). The serum copper content of CF group and S-ECC group was (20.18 ± 4.84) μmol/L and (19.49 ± 4.62) μmol/L, but the difference was not statistically significant (t=0.97, P=0.33). Conclusion The contents of iron, zinc and vitamin D in the serum of S-ECC patients are low, suggesting that iron, zinc and vitamin D supplementation should be emphasized in the prevention and treatment of S-ECC.

Key words: severe early childhood caries, deciduous tooth caries, trace elements, iron, zinc, copper, vitamin D, primary prevention

CLC Number: 

  • R788

Table 1

Comparison of sex and age in the two groups n "

Group CF S-ECC Total χ2 P
Sex
Male 47 54 101 0.30 0.58
Female 42 41 83
Age(year)
3 25 22 47
4 30 29 59 1.30 0.52
5 34 44 78
Total 89 95 184

Table 2

Comparison of various indicators of men and women $\bar{x}±s$"

Group Fe(mmol/L) Zn(μmol/L) Cu(μmol/L) 25(OH)D(nmol/L)
Male 8.27 ± 0.42 81.30 ± 7.39 19.52 ± 4.37 81.18 ± 15.36
Female 8.22 ± 0.48 80.95 ± 6.76 20.20 ± 5.15 83.19 ± 13.14
t 0.78 0.32 -0.96 -0.94
P 0.43 0.74 0.33 0.34

Table 3

Comparison of various indicators in children aged 3-5 $\bar{x}±s$"

Indicator Age(year) CF S-ECC t P
Fe(mmol/L) 3 8.32 ± 0.35 8.10 ± 0.24 2.36 0.023
4 8.36 ± 0.48 8.09 ± 0.42 2.23 0.03
5 8.40 ± 0.42 8.17 ± 0.53 2.04 0.045
Total 8.36 ± 0.42 8.13 ± 0.44 3.5 <0.001
Zn(μmol/L) 3 81.16 ± 6.88 74.69 ± 4.74 3.70 0.001
4 83.62 ± 7.05 79.92 ± 6.10 2.14 0.036
5 84.29 ± 7.66 81.04 ± 6.29 2.06 0.043
Total 83.18 ± 7.28 79.23 ± 6.38 3.92 <0.001
Cu(μmol/L) 3 20.06 ± 5.19 18.11 ± 3.76 1.45 0.15
4 20.87 ± 4.34 19.15 ± 5.01 1.41 0.16
5 19.65 ± 5.07 20.42 ± 4.65 -0.69 0.49
Total 20.18 ± 4.84 19.49 ± 4.62 0.97 0.33
25(OH)D(nmol/L) 3 87.16 ± 15.03 79.77 ± 7.62 2.08 0.043
4 88.09 ± 18.78 78.77 ± 12.82 2.21 0.03
5 85.17 ± 13.79 76.07 ± 11.93 3.12 0.003
Total 86.72 ± 15.83 77.75 ± 11.38 4.42 <0.001
[1] 葛立宏. 儿童口腔医学[M] . 第4版. 北京: 人民卫生出版社, 2014: 114.
Ge LH. Pediatric dentistry [M]. 4th ed. Beijing: People′s Medical Publishing House, 2014: 114.
[2] Gierat-Kucharzewska B, Karasiński A. Influence of chosen elements on the dynamics of the cariogenic process[J]. Biol Trace Elem Res, 2006,111(1-3):53-62.
doi: 10.1385/BTER:111:1:53
[3] Vandeputte DF, Ameloot PC, Cleymaet R, et al. Localization of lead and fluoride in cultured tooth germs by laser microprobe mass analysis[J]. Biol Trace Elem Res, 1989,23(1):133-144.
[4] Sierpinska T, Konstantynowicz J, Orywal K, et al. Copper deficit as a potential pathogenic factor of reduced bone mineral density and severe tooth wear[J]. Osteoporos Int, 2014,25(2):447-454.
doi: 10.1007/s00198-013-2410-x pmid: 23797848
[5] Schroth RJ, Lavelle C, Tate R, et al. Prenatal vitamin D and dental caries in infants[J]. Pediatrics, 2014,133(5):e1277-e1284.
doi: 10.1542/peds.2013-2215 pmid: 24753535
[6] Zerofsky M, Ryder M, Bhatia S, et al. Effects of early vitamin D deficiency rickets on bone and dental health, growth and immunity[J]. Matern Child Nutr, 2016,12(4):898-907.
doi: 10.1111/mcn.12187 pmid: 25850574
[7] Kim IJ, Lee HS, Ju HJ, et al. A cross-sectional study on the association between vitamin D levels and caries in the permanent dentition of Korean children[J]. BMC Oral Health, 2018,18(1):43.
pmid: 29534753
[8] 王兴. 第四次全国口腔健康流行病学调查报告 [M]. 北京 : 人民卫生出版社, 2018.
Wang X. Report of the fourth national epidemiological survey of oral health [M]. Beijing: People′s Medical Publishing House, 2018.
[9] 王安平. 新疆乌鲁木齐地区学龄前儿童龋齿流行情况及影响因素分析[J]. 中国妇幼保健, 2019,34(5):1129-1132.
Wang AP . Prevalence of dental caries in preschool children in urumqi, xinjiang and analysis of influencing factors[J]. Matern Child health Care Chin, 2019,34(5):1129-1132.
[10] Stanner S. Iron deficiency in infancy and childhood[J]. Nutr Bull, 2003,28(2):221-225.
[11] Schroth RJ, Levi J, Kliewer E, et al. Association between iron status, iron deficiency anaemia, and severe early childhood caries: a case-control study[J]. BMC Pediatr, 2013,13(1):22-22.
[12] Atasoy HB, Ulusoy ZI. The relationship between zinc deficiency and children′s oral health[J]. Pediatr Dent, 2012,34(5):383-386.
pmid: 23211913
[13] Losee FL, Adkins BL. A study of the mineral environment of caries-resistant navy recruits[J]. Caries Res, 1969,3(1):23-31.
doi: 10.1159/000259588 pmid: 5268322
[14] 吴红昆, 周学东, 张萍, 等. 六种防龋制剂对牙釉质脱矿作用的研究[J]. 华西口腔医学杂志, 1999,17(2):113-115.
Wu HK, Zhou XD, Zhang P , et al. Study on the demineralization of enamel by six anticarious agents[J]. West China J Stomatol, 1999,17(2):113-115.
[15] Grant WB. A review of the role of solar ultraviolet-B irradiance and vitamin D in reducing risk of dental caries[J]. Dermatoendocrinol, 2011,3(3):193-198.
doi: 10.4161/derm.3.3.15841 pmid: 22110779
[16] 肖小芬, 何姗丹, 陈泳怡, 等. 不同龋敏感程度学龄前儿童的牙菌斑微生物群落研究[J]. 口腔疾病防治, 2019,27(12):763-768.
Xiao XF, He SD, Chen YY , et al. Study on the dental plaque microbial community in preschool children with different caries sensitivity[J]. J Prev Treat Stomatol Dis, 2019,27(12):763-768.
[17] Chhonkar A, Gupta A, Arya V, et al. Comparison of vitamin D level of children with severe early childhood caries and children with no caries[J]. Int J Pediatr Dent, 2018,11(3):199-204.
[18] Deane S, Schroth RJ, Sharma A, et al. Combined deficiencies of 25-hydroxyvitamin D and anemia in preschool children with severe early childhood caries: a case-control study[J]. Paediatr Child Health, 2018,23(3):e40-e45.
pmid: 29769814
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