Journal of Prevention and Treatment for Stomatological Diseases ›› 2020, Vol. 28 ›› Issue (10): 664-667.doi: 10.12016/j.issn.2096-1456.2020.10.009

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Advances in Treponema denticola and oral diseases

PENG Ruiting1,2(),CHENG Lei1,2,PENG Xian2()   

  1. 1. State Key Laboratory of Oral Diseases & Department of Endodontics in West China Hospital of Stomatology & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610064, China
    2. State Key Laboratory of Oral Diseases & West China Hospital of Stomatology & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610064, China
  • Received:2019-11-17 Revised:2020-06-21 Online:2020-10-20 Published:2020-09-01
  • Contact: Xian PENG E-mail:751233069@qq.com;pengx@scu.edu.cn

Abstract:

Treponema denticola is an important pathogenic Treponema pathogen in the human oral cavity. Early studies have found that Treponema denticola is closely related to the occurrence and development of periodontal diseases. With the development of technical methods in recent years, many studies have shown that Treponema denticola not only can participate in periodontal diseases through a variety of mechanisms but also can play an important role in the development of various oral diseases. Treponema denticola is detected in high concentrations in peri-apical diseases and peri-implant diseases, and its surface protein is also prevalent in oral tumor samples. This paper reviews the research progress of Treponema denticola in periodontal diseases, pulp peri-apical diseases, peri-implant diseases and oral tumors, and summarizes the relevant mechanisms. For example, Treponema denticola can cause immune regulation disorder, destroy the epithelial barrier, induce bone absorption, promote the occurrence and development of inflammation through a variety of surface proteins, including chymotrypsin-like protease complex (CTLP), major outer sheath protein (Mosp), Td92, and LOS. It can also escape complement-mediated killing effects through surface FhbB lipoproteins and promote the occurrence and development of oral tumors by regulating the tumor microenvironment. These theories provide a theoretical basis for further understanding the development of oral diseases, controlling the infection of Treponema denticola, and exploring more effective treatment strategies.

Key words: Treponema denticola, dental plaque, infection, periodontitis, pulp peri-apical diseases, peri-implant diseases, oral tumor, outer membrane protein, chymotrypsin-like protease complex, major outer sheath protein

CLC Number: 

  • R78
[1] Johnson DI. Treponema spp[M]. Bacterial Pathogens and Their Virulence Factors. Springer, Cham, 2018: 381-387.
[2] Kokubu E, Inoue T, Ishihara K. Response of epithelial cells infected by Treponema denticola[J]. Oral Dis, 2018,24(1-2):14-18.
doi: 10.1111/odi.12794 pmid: 29480639
[3] Ruby J, Martin M, Passineau MJ, et al. Activation of the innate immune system by Treponema denticola periplasmic flagella through Toll-like receptor 2[J]. Infect Immun, 2017,86(1):e00573-17.
doi: 10.1128/IAI.00573-17 pmid: 29084899
[4] Kikuchi Y, Kimizuka R, Kato T, et al. Treponema denticola induces epithelial barrier dysfunction in polarized epithelial cells[J]. Bull Tokyo Dent Coll, 2018,59(4):265-275.
pmid: 30333370
[5] Tsai CY, Tang CY, Tan TS, et al. Subgingival microbiota in individuals with severe chronic periodontitis[J]. J Microbiol Immunol Infect, 2018,51(2):226-234.
doi: 10.1016/j.jmii.2016.04.007 pmid: 27262209
[6] Rôças IN, Siqueira JF. Frequency and levels of candidate endodontic pathogens in acute apical abscesses as compared to asymptomatic apical periodontitis[J]. PloS One, 2018,13(1):e0190469.
doi: 10.1371/journal.pone.0190469 pmid: 29293651
[7] Nieminen MT, Listyarifah D, Hagstrom J, et al. Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation[J]. Br J Cancer, 2018,118(3):428-434.
doi: 10.1038/bjc.2017.409 pmid: 29149107
[8] Yoshikawa K, Kikuchi Y, Kokubu E, et al. Identification of a specific domain of Porphyromonas gingivalis Hgp44 responsible for adhesion to Treponema denticola[J]. Pathog Dis, 2018,76(5). DOI: 10.1093/femspd/fty047.
doi: 10.1093/femspd/fty046 pmid: 29718264
[9] Shin JE, Baek KJ, Choi YS, et al. A periodontal pathogen Treponema denticola hijacks the Fusobacterium nucleatum-driven host response[J]. Immunol Cell Biol, 2013,91(8):503-510.
doi: 10.1038/icb.2013.35 pmid: 23897119
[10] Barbosa AS, Isaac L. Complement immune evasion by spirochetes[J]. Curr Top Microbiol Immunol, 2018,415:215-238.
doi: 10.1007/82_2017_47 pmid: 28939965
[11] Fouad AF. Treponema spp. shown to be important pathogens in primary endodontic infections[J]. J Evid Based Dent Prac, 2016,16(1):50-52.
[12] Pattanshetty S, Kotrashetti VS, Bhat K, et al. Multiplex polymerase chain reaction detection of selected bacterial species from symptomatic and asymptomatic non-vital teeth with primary endodontic infections[J]. J Investig Clin Dent, 2018,9(2):e12312.
doi: 10.1111/jicd.12312 pmid: 29327500
[13] Guven Y, Ustun N, Aksakal SD, et al. Assessment of the endodontic microbiota of abscessed primary teeth using microarray technology[J]. Indian J Dent Res, 2018,29(6):781-786.
doi: 10.4103/ijdr.IJDR_19_18 pmid: 30589008
[14] Siqueira JrJF, Rôças IN. Treponema species associated with abscesses of endodontic origin[J]. Oral Microbiol Immunol, 2004,19(5):336-339.
doi: 10.1111/j.1399-302x.2004.00156.x pmid: 15327648
[15] Foschi F, Izard J, Sasaki H, et al. Treponema denticola in disseminating endodontic infections[J]. J Dent Res, 2006,85(8):761-765.
doi: 10.1177/154405910608500814 pmid: 16861296
[16] Nelson-Filho P, Ruviére DB, de Queiroz AM, et al. Comparative molecular analysis of Gram-negative bacteria in primary teeth with irreversible pulpitis or periapical pathology[J]. Pediatr Dent, 2018,40(4):259-264.
pmid: 30345964
[17] Shin YJ, Choung HW, Lee JH, et al. Association of periodontitis with oral cancer: a case-control study[J]. J Dent Res, 2019,98(5):526-533.
doi: 10.1177/0022034519827565 pmid: 30779879
[18] Narikiyo M, Tanabe C, Yamada Y, et al. Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers[J]. Cancer Sci, 2004,95(7):569-574.
doi: 10.1111/j.1349-7006.2004.tb02488.x pmid: 15245592
[19] Ganly I, Yang L, Giese RA, et al. Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus[J]. Int J Cancer, 2019,145(3):775-784.
doi: 10.1002/ijc.32152 pmid: 30671943
[20] Kylmä AK, Jouhi L, Listyarifah D, et al. Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma[J]. Br J Cancer, 2018,119(1):89-98.
doi: 10.1038/s41416-018-0143-5 pmid: 29930251
[21] Listyarifah D, Nieminen MT, M?kinen LK, et al. Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features[J]. J Oral Pathol Med, 2018,47(8):764-772.
doi: 10.1111/jop.12729 pmid: 29747237
[22] Tallarico M, Canullo L, Caneva M, et al. Microbial colonization at the implant-abutment interface and its possible influence on periimplantitis: a systematic review and meta-analysis[J]. J Prosthodont Res, 2017,61(3):233-241.
doi: 10.1016/j.jpor.2017.03.001 pmid: 28359872
[23] Costa FO, Ferreira SD, Cortelli JR, et al. Microbiological profile associated with peri-implant diseases in individuals with and without preventive maintenance therapy: a 5-year follow-up[J]. Clin Oral Investig, 2019,23(8):3161-3171.
doi: 10.1007/s00784-018-2737-y pmid: 30386996
[24] Wang H L, Garaicoa-Pazmino C, Collins A, et al. Protein biomarkers and microbial profiles in peri-implantitis[J]. Clin Oral Implants Res, 2016,27(9):1129-1136.
doi: 10.1111/clr.12708 pmid: 26424287
[25] Yu X, Hu Y, Freire M, et al. Role of toll-like receptor 2 in inflammation and alveolar bone loss in experimental peri-implantitis versus periodontitis[J]. J Periodontal Res, 2018,53(1):98-106.
pmid: 28872184
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