Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (4): 240-244.doi: 10.12016/j.issn.2096-1456.2018.04.008

• Cinical Study • Previous Articles     Next Articles

The effects of intramuscular injections of vitamin B1 and B12 on pain, salivary components and taste in patients with burning mouth syndrome

Xixi YU1(), Jian Lü2, Caixia WANG2, Yiheng WANG3, Songsong DENG1, Lulu LI1, Wanchun WANG2()   

  1. 1. Department of Stomatology, QingDao University School of Stomatology, Qingdao 266000, China
    2. Department of Oral Medicine, QingDao Stomatological Hospital, QingDao 266000, China
    3. Department of Stomatology, Weifang Medical College of Stomatology, Weifang 261000, China
  • Received:2017-11-30 Revised:2018-01-11 Online:2018-04-20 Published:2018-08-31

Abstract:

To determine differences in pain, salivary components and taste between burning mouth syndrome (BMS) patients and the normal population and to study the effects of intramuscular injections of vitamin B1 (VitB1) and vitamin B12 (VitB12) on BMS. Before treatment: We observed and compared differences in unstimulated salivary flow rate (USFR); stimulated salivary flow rate (SSFR); salivary amylase, cortisol, and secretory immunoglobulin A (SIgA) concentrations; and taste levels between BMS patients and normal controls. After treatment: The treatment group received an intramuscular injection of 100 mg VitB1 and 0.5 mg VitB12 in the buttocks once per day for 10 days. The above indexes were recorded before and after treatment and compared. A visual analog scale (VAS) score was used to assess the degree of pain relief in patients and as a clinical evaluation index. Before treatment: SSFR, salivary amylase levels and bitter taste levels of the treatment group were significantly lower than those of the control group (P < 0.05). The concentration of SIgA was significantly higher than that of the control group (P < 0.05), and the USFR and the cortisol concentration were not significant different from the those of the control group (P > 0.05). After treatment: The total effective rate of VitB1 and VitB12 on BMS was up to 70%. USFR was increased significantly after treatment (P < 0.05), and the concentration of SIgA decreased (P < 0.05). There were no significant differences in the SSFR or the cortisol and salivary amylase concentrations (P > 0.05). Taste levels improved by varying degrees. The abnormal decreases in SSFR, salivary amylase levels, and taste sensitivity and the abnormal increase in SIgA levels seen in BMS patients may be sensitive salivary indicators for the diagnosis of BMS. A VitB1 and VitB12 intramuscular injection is an effective treatment for patients with BMS, who showed pain relief. Changes in SIgA levels may be used as an indicator during follow-up and for the prognosis of BMS patients.

Key words: Burning mouth syndrome, Saliva flow rate, Saliva components, Taste, Vitamin B1, Vitamin B12

Table 1

Analysis of salivary flow rates in the treatment group and the control groupn = 20,\(overline{x}\) ± s,mL/min"

组别 USFR SSFR
病例组 0.13 ± 0.05 1.07 ± 0.58
对照组 0.30 ± 0.37 1.69 ± 1.13
t -1.98 -2.18
P 0.06 0.03

Table 2

Analysis of salivary amylase, cortisol, and SIgA in the rest saliva components in the case group and control group n = 20,\(overline{x}\)± s,ng/mL"

组别 唾液淀粉酶 皮质醇 SIgA
病例组 8047.98 ± 4055.72 141.57 ± 129.87 22451.19 ± 10268.48
对照组 13255.39 ± 6528.80 122.22 ± 101.74 12989.37 ± 8061.17
t -3.03 0.52 3.24
P <0.001 0.61 <0.001

Table 3

Analysis of taste levels (acid, sweet, bitter and salty) in the treatment group and control group n = 20"

组别
秩均值 秩和 秩均值 秩和 秩均值 秩和 秩均值 秩和
病例组 21.00 420.00 23.48 469.50 24.78 495.50 21.60 432.00
对照组 20.00 400.00 17.52 350.50 16.23 324.50 19.40 388.00
Z -0.47 -1.69 -2.44 -0.86
P 0.64 0.91 0.02 0.34

"

组别 USFR SSFR
治疗前 0.13 ± 0.05 1.07 ± 0.58
治疗后 0.20 ± 0.93 1.13 ± 0.45
t 4.32 0.51
P <0.001 0.61

Table 5

Comparison of salivary amylase, cortisol, and SIgA levels in the unstimulated saliva components in the treatment group before and after treatment n = 20,\(overline{x}\) ± s,ng/mL"

组别 唾液淀粉酶 皮质醇 SIgA
治疗前 8047.98 ± 4055.72 141.57 ± 129.87 22451.19 ± 10268.48
治疗后 8597.92 ± 4624.27 78.95 ± 69.80 11245.32 ± 4343.39
t 1.82 1.70 -5.04
P 0.07 0.09 <0.001
[1] Kamala KA, Sankethguddad S, Sujith SG, et al.Burning mouth syndrome[J]. Indian J Palliat Care, 2016, 22(1): 74-79.
[2] Aravindhan R, Santhanam V, Kumar MS, et al.Burning mouth syndrome:a review on its diagnostic and therapeutic approach[J]. J Pharm Bioallied Sci, 2014, 7(6): 21-25.
[3] Scala A, Checchi L, Montevecchi M, et al.Update on burning mouth syndrome:overview and patient management[J]. Crit Rev Oral Biol Med, 2003, 14(4): 275-291.
[4] Sevrain M, Brenaut E, Le Toux G, et al.Primary burning mouth syndrome:a questionnaire study of neuropathic and psychological components[J]. Am J Clin Dermatol, 2016, 17(2): 171-178.
[5] 张文怡, 吴迎涛, 王万春. 唾液因素在口腔感觉异常征中的研究进展[J]. 临床口腔医学杂志, 2015, 31(8): 510-511.
[6] Merigo E, Manfredi M, Zanetti MR, et al.Burning mouth syndrome and personality profiles[J]. Minerva Stomatol, 2007, 56(4): 159-167.
[7] Lee YC, Hong IK, Na SY, et al.Evaluation of salivary function in patients with burning mouth syndrome[J]. Oral Dis, 2015, 21(3): 308-313.
[8] Henkin RI.Testing taste[J]. Lancet, 1987, 2(8557): 515.
[9] Markley EJ, Mattes-Kulig D, Henkin RI.A classification of dysgeusia[J]. J Am Diet Assoc, 1983, 83(5): 578-580.
[10] Nagler RM, Hershkovich O.Sialochemical and gustatory analysis in patients with oral sensory complaints[J]. J Pain, 2004, 5(1): 56-63.
[11] Heller GZ, Manuguerra M, Chow R.How to analyze the visual analogue scale:myths, truths and clinical relevance[J]. Scand J Pain, 2016, 10(13): 67-75.
[12] 赵曼,陈谦明,林梅, 等. 灼口综合征患者静态唾液流速和口干症状的相关研究[J]. 华西口腔医学杂志. 2001,19(3): 169-170.
[13] Granot M, Nagler RM.Association between regional idiopathic neuropathy and salivary involvement as the possible mechanism for oral sensory complaints[J]. J Pain, 2005, 6(9): 581-587.
[14] Hershkovich O, Nagler RM.Biochemical analysis of saliva and taste acuity evaluation in patients with burning mouth syndrome,xerostomia and/or gustatory disturbances[J]. Arch Oral Bio, 2004, 49(7): 515-522.
[15] Kim HI, Kim YY, Chang JY, et al.Salivary cortisol, 17β-estradiol, progesterone, dehydroepiandrosterone, and α-amylase in patients with burning mouth syndrome[J]. Oral Dis, 2012, 18(6):613-620.
[16] Mendakziółko M, Konopka T, Bogucki ZA. evaluation of select neurophysiological,clinical and psychological tests for burning mouth syndrome[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2012, 114(3): 325-332.
[17] 吴春根, 何安慰. 硬膜外注射甲基维生素B12治疗周围神经脱髓鞘病变临床观察[J]. 海军医学杂志, 2012, 33(4): 219-222.
[18] Lin HP, Wang YP, Chen HM, et al.Significant association of hematinic deficiencies and high blood homocysteine levels with burning mouth syndrome[J]. J Formos Med Assoc, 2013, 112(6): 319-325.
[19] Sun A1, Lin HP, Wang YP, et al. Significant reduction of serum homocysteine level and oral symptoms after different vitamin-supplement treatments in patients with burning mouth syndrome[J]. J Oral Pathol Med, 2013, 42(6): 474-479.
[20] 黎慧瑜. 22例灼口综合征的疗效观察[J]. 广东牙病防治, 2001, 9(3): 194-195.
[1] GE Shuyun,ZHOU Haiwen,WAN Yi,ZHOU Zengtong. Clinical effect of auricular point therapy on burning mouth syndrome [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(3): 174-177.
[2] YU Xixi,WANG Caixia,WANG Wanchun. Research progress on primary burning mouth syndrome [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(12): 810-816.
[3] Pingjie WEI, Xiaohe WANG. Clinical effect of lipoic acid in burning mouth syndrome [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(11): 737-739.
[4] LU Jian-rong, BAN Hua-jie, WANG Dai-you, ZHOU Hui-hui, LONG Ru, QIN Shu-hua. Clinical observation of sternocleidomastoid muscle flaps combined with artificial biological membrane reparing the defects after parotidectomy [J]. journal1, 2016, 24(1): 29-32.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Hong-chang LAI,Jun-yu SHI. Maxillary sinus floor elevation[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(1): 8 -12 .
[2] Pin ZHOU, Yang-fei LI. MRI study of temporomandibular joint disc position in asymptomatic volunteers[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(4): 239 -244 .
[3] Xinxin XIA, Fang FANG, Lijuan CHENG. Shaping ability of Pathfile and WaveOne in simulated root canals[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(6): 365 -368 .
[4] Yuanhong LI, Xinyi FANG, Yu QIU, Lei CHENG. Experimental study on the effects of green tea on salivary flow rate and pH value[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(9): 560 -564 .
[5] Chengzhang LI. Masticatory muscles in occlusion[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(12): 755 -760 .
[6] . [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(1): 1 .
[7] Zhirong WU, Shiguang Huang. Research progress on the etiology, clinical examination and treatment of peri-implantitis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(6): 401 -405 .
[8] Xiaowu YAO, Shisheng CHEN, Zizheng LU, Minxiao LIN. Clinical report and literature review on the amyloidosis of salivary glands[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(8): 533 -536 .
[9] Lan LIAO, Lijun ZENG. Updated research on digitalization in aesthetic restoration[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 409 -414 .
[10] Yu LU, Chengxia LIU, Zhongjun LIU. Role of TRAF6 in inflammatory responses of human osteoblast-like cells with Enterococcusfaecalis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(7): 420 -425 .
This work is licensed under a Creative Commons Attribution 3.0 License.