Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (11): 718-722.DOI: 10.12016/j.issn.2096-1456.2019.11.006

• Cinical Study • Previous Articles     Next Articles

Study of the therapeutic effect of oral propranolol combined with topical timolol maleate in the treatment of mixed maxillofacial hemangioma in infants

LI Jiapeng1,CHEN Jufeng1,ZHANG Guorun1,XIAN Dan1,LI Jin1,WANG Lei1,ZHANG Guoyi2()   

  1. 1. Stomatological Center, Foshan First People′s Hospital, Foshan 528000, China;
    2. Nasopharyngeal Radiotherapy Department 2, Foshan First People′s Hospital, Foshan 528000, China;
  • Received:2019-04-04 Revised:2019-05-16 Online:2019-11-20 Published:2019-12-03
  • Contact: Guoyi ZHANG

口服普萘洛尔联合局部外用马来酸噻吗洛尔治疗婴幼儿颌面部混合性血管瘤的临床效果

李嘉朋1,陈巨峰1,张国润1,冼淡1,李金1,王磊1,张国义2()   

  1. 1. 佛山市第一人民医院口腔医学中心,广东 佛山(528000)
    2. 佛山市第一人民医院鼻咽放疗二科,广东 佛山(528000)
  • 通讯作者: 张国义
  • 作者简介:李嘉朋,副主任医师,硕士,Email: 18038862068@189.cn
  • 基金资助:
    广东省科技计划项目(2017A020215128)

Abstract: Objective To observe the treatment effect of oral propranolol combined with topical timolol maleate for infantile maxillofacial mixed hemangioma and provide evidence for clinical treatment. Methods Ninety-seven cases of infantile maxillofacial mixed hemangioma were enrolled. The cases were randomly divided into A and B groups: 50 cases in group A were treated with oral propranolol combined with topical timolol maleate, and 47 cases in group B were treated with oral propranolol only. The changes in the color, volume, and texture of the tumors were recorded before and after treatment, and color ultrasonography of the lesion area was performed. The follow-up time was 1-12 months. The differences in the curative effect, effective time and adverse reaction between the two groups were compared. Results The effective rate of group A was 92.0% (46/50) and that of group B was 74.5% (35/47), with a statistical significance (P < 0.05). The mean time of treatment in group A was 4.2 months and that in group B was 5.5 months. Compared with group B, the treatment time of group B was shorter (t=3.211, P < 0.05), and no serious adverse reactions occurred in both groups. Conclusion Oral propranolol combined with topical timolol maleate is effective in the treatment of mixed hemangioma of the maxillofacial region in infants.

Key words: mixed hemangioma, infant, propranolol, timolol maleate, topical therapy, curative effect, adverse reactions

摘要: 目的 观察口服普萘洛尔与局部外用马来酸噻吗洛尔联合应用治疗婴幼儿颌面部混合性血管瘤的疗效,为临床治疗提供证据。 方法 选取婴幼儿颌面部混合性血管瘤97例,随机分成A、B 2组,A组50例,以口服普萘洛尔联合局部外用马来酸噻吗洛尔进行治疗,B组47例,仅口服普萘洛尔治疗。治疗前后记录瘤体颜色、体积、质地的变化,并完善彩超检查。随访时间为1~12个月。比较2组的疗效差异、显效时间及不良反应的差异。 结果 A组有效率为92.0%(46/50), B组有效率为74.5%(35/47),差异具有统计学意义(P < 0.05)。A组平均治疗时间为4.2个月,B组平均治疗时间为5.5个月,相较于B组,A组治疗显效时间较快,差异具有统计学意义(t=3.211,P < 0.05)。2组均未见严重不良反应。 结论 口服普萘洛尔与局部外用马来酸噻吗洛尔联合应用治疗婴幼儿颌面部混合性血管瘤效果良好。

关键词: 混合性血管瘤, 婴幼儿, 普萘洛尔, 马来酸噻吗洛尔, 局部治疗, 疗效, 不良反应

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