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20 May 2017, Volume 25 Issue 5
    

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    Expert Forum
  • Hong-zhang HUANG, Cheng WANG
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 273-281. https://doi.org/10.12016/j.issn.2096-1456.2017.05.001
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    With the development of computer science and biotechnology, medical data has been dramatically increased and demonstrated the properties of variety and complexity. Biological and clinical researchers now face increasingly large and complex data sets. In the era of big data, strategies of diagnosis and treatment of cancer are gradually changed from evidence-based medicine to precision medicine. The promise of the big data paradigm may affect patients with oral cancer by enabling personalized monitoring, diagnosis and treatment. In this article, we will review the advances of diagnosis and treatment modality in oral cancer based on big data platform, which is mainly focused on oral cancer screening, early detection, molecular classification, prediction of metastasis and chemosensitivity.

  • Special Articles
  • Wen-shu GE, Yao ZHANG, Yi ZHANG, Jian-ying HU, Yong JIANG
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 282-287. https://doi.org/10.12016/j.issn.2096-1456.2017.05.002
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    Objective Meta-analysis was used to assess the effect of Nd: YAG Lasers used in root canal therapy. Methods A search of literatures about clinical effect of Nd:YAG lasers in root canal therapy in PubMed, Embase, Cochrane Library, CMCC, CNKI, VIP, Wanfang databases was conducted from 1997 to 2015. The quality of included studies was stringently evaluated and data was analyzed by the RevMan 5.3 software. Results 8 studies were included in the Meta-analysis. Meta-analysis results showed that the ratio of the occurrence of endodontic interappointment emergencies (EIAE) of 24 ~ 48 hours and 1 week after the therapy was significantly lower in the Nd: YAG lasers group compared with the control group (24 h: OR = 0.27, 95%CI = 0.15 ~ 0.48; 1week: OR = 0.26, 95%CI = 0.13 ~ 0.54). The six months to one year failure rate of root canal therapy was lower in Nd:YAG lasers group compared with the control group, the differences were statistically significant (OR = 0.24, 95%CI = 0.06 ~ 1.00). Conclusion The use of Nd: YAG laser in root canal therapy relieves post-treatment pain response after the therapy and also reduces the long-term failure rate of root canal treatment.

  • Basic Study
  • Jian-zhen YANG, Xiao-qing SHEN, Cheng-xia LIU, Ping-ping XU
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 288-293. https://doi.org/10.12016/j.issn.2096-1456.2017.05.003
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    Objective To study the blocking effect and abrasion resistance of hydroxyapatite (HA) with different particle sizes and morphologyies on dentinal tubules from the qualitative and quantitative aspects. Methods Dentin discs were etched and divided into 4 groups randomly: 20 nm HA group; 30 nm HA group; 12 μm HA group; control group (without any experimental treatment). Each group was brushed with correspondent materials for 7 days. Then, the dentin disk was divided into two parts, the one was detected by the scanning electron microscopy (SEM); the other was observed by SEM after toothbrush abrasion test. The Image-Pro Plus 6.0 image analysis software was used to calculate the plugging rate of dentinal tubules. Results SEM showed that the blockage is granular, the plugging rate of the dentinal tubules were about 82% to 96%. 30 nm HA group (short rod) range the first in the average plugging rate, followed by the 20 nm HA group (needles) and 12 μm HA group (spherical). After mechanical brushing for 7 days, SEM images showed that deposited layer in each group was smooth and compact, and more than 63% of the tubules still had been blocked. Conclusion HA with different particle sizes and morphologies had good plugging effect and abrasion resistance on dentine tubules. The blocking effect of HA was affected not only by particle size but also by the morphology.

  • Ya-nan WANG, Hao LIU, Jun ZHANG
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 294-299. https://doi.org/10.12016/j.issn.2096-1456.2017.05.004
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    Objective This study ai ms to evaluate the expression of autophagy-related protein cancer phosphatase and tensinhomology deleted on chromosome ten (PTEN) and microtubule-associated protein 1 light chain 3 (MAP1LC3) and investigate its significance in tongue squamous cell carcin oma (TSCC). Methods About 46 TSCC samples, 13 cases of precancerous lesion and 13 cases of adjacent tissues were enrolled. Immunohistochemistry were performed to examine the expression of PTEN, MAP1LC3. Statistical analyses were carried out to assess the associations among clinic pathologic parameters. Results The positive expression rate of PTEN (34.78%) in TSCC was significantly lower than that in adjacent tissues (69.23%, χ2 = 4.926, P = 0.026) and precancerous lesions (76.92%, χ2 = 7.302, P = 0.007). The positive expression rate of MAP1LC3 (28.26%) in TSCC was significantly lower than that of adjacent tissues (61.53%, χ2 = 4.896, P = 0.027) and precancerous lesions (69.23%, χ2 = 7.275, P = 0.007), the difference was statistically significant. The expression of PTEN and MAP1LC3 was not correlated with age, sex, smoking, alcohol consumption and cell differentiation (P > 0.05). There was a significant difference in the expression of PTEN and MAP1LC3 in subgroup with different clinical stage and in subgroup with or without lymph node metastasis (P < 0.05). There is a significant difference in the tumor recurrence between PTEN protein expression positive subgroup and PTEN protein expression negative subgroup (χ2 = 4.629,P = 0.039), and there was no significant difference in the tumor recurrence between MAP1LC3 protein expression positive subgroup and MAP1LC3 protein expression negative subgroup (χ2 = 0.343,P = 0.453). There was a positive correlation between PTEN and MAP1LC3. Conclusion The expression of PTEN and MAP1LC3 suggested that autophagy associated proteins play a pivotal role in the progression, diagnosis and prognosis of TSCC. Down-regulation of PTEN and MAP1LC3 was observed in TSCC.

  • Cinical Study
  • Yin LIU, Xue-qi LI, Yu CHEN, Yang CAO
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 300-304. https://doi.org/10.12016/j.issn.2096-1456.2017.05.005
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    Objective To investigate the correlation between mandibular Bonwill-Hawley arch and base bone archshape. Methods CBCT and Mimics10.01 software were used to locate and measure the mandibular arch of 32 patients with type Ⅰ malocclusion. The individualized Bonwill-Hawley arch was drawn and the length and width of the arch and base arch were measured, and the data were compared and analyzed by SPSS 16.0 software. Results Pearson correlation analysis results showed significant correlation between Bonwill-Hawley arch and base bone arch in both length and width (r>0.5). Compared with base bone arch, anterior (t=0.81, P=0.25) and medium (t=0.69, P=0.50)Bonwill-Hawley arch showed no statistical difference in both length and width (P>0.05), while posterior Bonwill-Hawley arch showed significant statistical difference in length (t=2.21, P=0.03) and width (t=2.42, P=0.02). Conclusion There was significant correlation between Bonwill-Hawley arch and base bone arch in both length and width.

  • Zhe QU, Lan MA, Xiang ZHANG, Hai-yang ZHANG, Dan LI, Zhan-xin WANG
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 305-310. https://doi.org/10.12016/j.issn.2096-1456.2017.05.006
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    Objective To evaluate the plaque distribution on the fitting surface of fixed implant prostheses which were supported by multi-unit abutment. Methods 21 patients with maxillary full-arch implant-supported fixed prostheses were collected. Plaque accumulation at the fitting surfaces were evaluated 3 months after restoration, by analyzing the digital photographs recorded by Imag e J 2.1.4.7. Results The average percentage of area covered with plaque was (46.13 ± 7.23)%. Plaque accumulation on the buccal and palatal area were (41.53 ± 3.08) and (53.76 ± 3.07)% respectively, with a significant difference (t = 16.750, P < 0.001). The free area (71.86 ± 2.00) % was significantly higher than the anterior area (48.85 ± 2.09)% (t = 40.445, P < 0.001), andalso the middle area (49.33 ± 0.98)% (t = 47.124 , P < 0.001). The plaque percentage was higher when the distance between the implants was shorter. To Minimize the palatal extension and free area of the prostheses, and to maximize the distances between the implants, were helpful to improve the oral hygiene control. It might be the key to keep a good outcome of the maxillary full-arch implant-supported fixed prostheses.

  • Xian-feng WAN, Hui-ling WANG, Zhen-huan LIU, Jin-cai ZHANG, Pei-jia DUAN, Li-na BAO
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 311-315. https://doi.org/10.12016/j.issn.2096-1456.2017.05.007
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    Objective To provide the experimental basis for the coherence of the indirect bond position by comparing the position of the bracket on the digital occlusal model and the position of the transfer to the initial plaster model. Methods Fifteen digitized models were selected for the brackets on the dental denture model, the brackets were transferred to the initial plaster model by indirect bond transfer trays, The line distance between each bracket position in digital dental model and initial plaster model was measured with OrthoRx software. Results The difference between the position of the orthodontic brackets and the position of the initial plaster model was less than 0.20 mm, and the difference was statistically significant (P < 0.05). Conclusion The position of the bracket on the digital occlusal model is consistent with that of the original plaster model, which provides a theoretical basis for digital indirect bonding.

  • Rui-zhi JIA, Dong-mei YANG, Jia-jian SHANG
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 316-319. https://doi.org/10.12016/j.issn.2096-1456.2017.05.008
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    Objective To investigate the root canal numbers of maxillary second primary molars. Methods 216 max illary second primary molars from 204 children aged 3-8 years old were selected. All the teeth need to do the root canal therapy. After opening the pulp chamber, the root canal were examined and determined with small size K file and 17%ethylene diaminetetraacetic acid (EDTA). Hand instruments were used for root canal preparation and then zinc-oxide iodoform paste was used for filling. Results 216 maxillary second p rimary molars, 122 teeth had three root canals(56.5%), and 94 teeth had four root canals (43.5%). The incidence of second mesiobuccal canal (MB2) was 41.2%. There was no correlation between the incidence of the MB2 canal and gender and tooth position. Conclusion The root canals of maxillary second primary molars had more variations, and there was a high incidence of the second mesiobuccal canal.

  • Orginal Article
  • Jing WEN, Xi-chao HONG, Wen-xiu GAO, Feng HUANG
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 320-322. https://doi.org/10.12016/j.issn.2096-1456.2017.05.009
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    Objective To evaluate the clinical effects of mineral trioxide aggregate (MTA) as apulp-dressing agent in immature permanent anterior teeth. Methods 68 perma nent anterior teeth with deep caries or accidental pulp exposure were randomly divided into treatment group (MTA) and control group (calcium hydroxide). The exposed pulps were treated permanently with direct pulp capping. The effect of potential clinical variables on the treatment outcome was evaluated clinically and radiographically during a 24-month follow-up. In order to assess the cumulative successes, data were analyzed with chi-square test and log-rank test (α= 0.05). Results The successful rate of the treatment group (91.4%) was higher than that of the control group (60.6%) significantly (P < 0.05). None of the gender, occlusal site, type of pulp exposure, site and diameter of pulp exposure had a considerable influence on the outcome (P > 0.05). Conclusion MTA as a biocompatable, osteogenesis-inducing and inflammation-controlling material appears to be suitable for direct pulp capping.

  • Prevention and Treatment Practice
  • Rong-rong LI, Yan-wen ZHAO, Jun ZHOU, Mei-juan GAO, Jin-cheng NIU, Dong-xu LIU
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 323-326. https://doi.org/10.12016/j.issn.2096-1456.2017.05.010
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    Objective To simulate the hypoxic environment of cells in vivo more approximately, a hypoxia control device which can control oxygen concentration automatically for cell culture in vitro was developed. Methods In vitro cell cultur e hypoxia control device consisted of hardware and software which were controlled by computer. The hardware was composed of oxygen detection and control system, nitrogen gas pipeline, cell culture and anti-jamming device, and the software was based on Clanguage. When oxygen controlle rreads the oxygen concent ration more than the set value, the nitrogen gas pipeline opens and nitrogen enter into the incubator; when reaching the set value, the nitrogen gas pipeline closes and nitrogen is not allowed to pass through. Circularly, a constant oxygen concentration was reached and maintained. This device was further verified by comparing the set value of the equipment with figures of the oxygen meter and by monitoring fluctuation condition after the oxygen concentration reaching the set value. Results There was no significant difference between the oxygen concentration set in the in vitro cell culture hypoxia control device and the actual oxygen concentration in the measured box (P > 0.05), and the accuracy of the device to set the value of the simulation up to ± 0.5% of the requirements to meet the system accuracy requirements, and can remain stable for a long time. Conclusion The device can effectively control the oxygen concentration to the required requirements, to meet the conditions in the hypoxic conditions for in vitro cell culture.

  • Review Articles
  • Huan-dong ZHANG, Si-ming XIE
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 327-330. https://doi.org/10.12016/j.issn.2096-1456.2017.05.011
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    HH (hedgehog) signal pathway consists the hedgehoge ligand (Shh、Ihh and Dhh), the Patch and Smo membrane protein complex and Zinc finger transcription factor Gli (Gli1, Gli2, Gli3). In HH (hedgehog) signaling pathway, Gli1 not only plays a dominant and decisive role in the zinc finger transcription factor Gli (Glioma-associated oncogene homolog) family, but also includes epithelial-mesenchymal transition (EMT) and oral squamous cell carcinoma, tumor invasion and metastasis. The research on oral squamous cell carcinoma and Shh/Gli1 signal axis is rare. In this paper, the squamous cell carcinoma of oral epithelial mesenchymal transformation and correlation study of quality Gli1 is reviewed.

  • Yuan-yuan LUO, Zhong-juan TAN, Yue-ping ZHAO
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 331-335. https://doi.org/10.12016/j.issn.2096-1456.2017.05.012
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    The in itiation and progression of periodontal disease were reported to be the results of complicated interactions between specific subgingival bacteria and host immuno-inflammatory response. As a part of the immune and defense system mechanisms of the host, leptin may have a protective effect on periodontal tissues. We summarize the latest progress in the relationship between leptin and periodontitis.

  • Jie LIN, Zhen-xiang LIN, Zhi-qiang ZHENG, Qun CHEN, Zhao-jie LU
    Journal of Prevention and Treatment for Stomatological Diseases. 2017, 25(5): 336-340. https://doi.org/10.12016/j.issn.2096-1456.2017.05.013
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    An id eal balance between the post length within root and the coronal extension should exist. Some theories advocated the use of the longest post as possible as the apical seal is not disturbed. Others advocated that the post should be longer than the crown or that the post should be a certain fraction of the length of the root. The conventional post length has been equal to 2/3-3/4 of the root length from half a century ago. Most of these theories have emphasized the post length in order to achieve sufficient retention and rigidity for coronal restoration. However, dental materials are evolving.With the use of fiber post and resin cement, stress distribution and post retention are improved over conventional metal post and zinc phosphate or glass-ionomer cement. Therefore, with improved bonding strength of fiber post, the post length within root should be minimized to maintain sufficient coronal rigidity. Factors affecting fracture resistance balance of a post-and-core system include the amount of Ferrule height (FH), Post length in root (PLIR), Post length in bone (PLIB), Abutment height (AH), Core length (CL) and Post length out of bone (PLOB). In view of the factors mentioned above, this paper investigated the mechanical factorsin a post-and-core system with literature review.