口腔疾病防治 ›› 2020, Vol. 28 ›› Issue (5): 298-302.doi: 10.12016/j.issn.2096-1456.2020.05.005

• 临床研究 • 上一篇    下一篇

2 456例唾液腺肿瘤临床病理分析

王张嵩1,谢舒乐1,张汉卿1,方泽震1,李群星2,范松1,李劲松1()   

  1. 1. 中山大学孙逸仙纪念医院口腔颌面外科,广东 广州(510120)
    2. 中山大学光华口腔医学院·附属口腔医院,广东 广州(510055;
  • 收稿日期:2019-08-27 修回日期:2020-01-10 出版日期:2020-05-20 发布日期:2020-04-24
  • 通讯作者: 李劲松 E-mail:lijinsong1967@163.com
  • 作者简介:王张嵩,医师,硕士研究生在读,Email: 1790327737@qq.com
  • 基金资助:
    国家自然科学基金项目(81872194);国家自然科学基金项目(81672676);国家自然科学基金项目(81772890)

Clinical and pathological analysis of 2 456 cases of salivary gland tumor

WANG Zhangsong1,XIE Shule1,ZHANG Hanqing1,FANG Zezhen1,LI Qunxing2,FAN Song1,LI Jinsong1()   

  1. 1. Department of Oral & Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China;
    2. Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China
  • Received:2019-08-27 Revised:2020-01-10 Online:2020-05-20 Published:2020-04-24
  • Contact: Jinsong LI E-mail:lijinsong1967@163.com

摘要:

目的 探讨唾液腺肿瘤的发病、病理类型等临床特点。方法 收集中山大学孙逸仙纪念医院口腔颌面外科1973年1月至2018年12月间确诊的唾液腺肿瘤病例2 456例患者的相关资料,回顾分析其性别、年龄、病理类型、发病部位、良恶性构成比等特点。结果 46年间收治的唾液腺肿瘤患者2 456例,女性比例占41.9%,男性占 58.1%,40~60岁年龄段为发病高峰,其中良性肿瘤 1 863 例(75.9%),恶性肿瘤593 例(24.1%),良恶性之比为3.1∶1。良性肿瘤构成比前2位是多形性腺瘤(58.7%)、Warthin瘤(33.6%),恶性肿瘤构成比前2位是黏液表皮样癌(27.7%)、腺样囊性癌(26.1%)。最常见的良性肿瘤多形性腺瘤的好发部位是腮腺、腭部、颌下腺, 而恶性肿瘤中粘液表皮样癌则常见于腮腺和腭部的小唾液腺。本组资料中唾液腺肿瘤发病呈逐年递增的趋势,近10年病例占总病例数的53.3%。结论 唾液腺肿瘤病人数量逐年增加;唾液腺肿瘤的总发生率男性高于女性;大唾液腺以良性肿瘤为主,小唾液腺恶性肿瘤多见;多形性腺瘤、Warthin瘤、黏液表皮样癌最常见;40~60岁是唾液腺良、恶性肿瘤高发年龄段。

关键词: 唾液腺; 肿瘤; 多形性腺瘤; Warthin瘤; 黏液表皮样癌; 腺样囊性癌; 病理学; 回顾性分析

Abstract:

Objective To investigate the clinical characteristics of salivary gland tumors and their pathological types.Methods Data from 2 456 patients with salivary gland tumors diagnosed between January 1973 and December 2018 at Sun Yat-sen Memorial Hospital of Sun Yat-sen University were collected, and their gender, age and tumor pathological type, location, and benign and malignant composition ratios were retrospectively analyzed.Results Over the 46-year study period, 2 456 patients with salivary gland tumors were treated; 41.9% were female, and 58.1% were male. The peak incidence was found among the 40 to 60 years of age group, in which 593 (24.1%) patients had malignant tumors and 1 863 (75.9%) had benign tumors. The ratio of benign and malignant tumors was 3.1∶1. The top two most common benign tumors were pleomorphic adenoma (58.7%) and Warthin tumors (33.6%). The top two most common malignant tumors were mucoepidermoid carcinoma (27.7%) and adenoid cystic carcinoma (26.1%). The most common sites of benign pleomorphic adenomas were the parotid glands, palate, and submandibular glands. Mucinous epidermoid carcinomas in malignant tumors were common in the parotid glands and small salivary glands. The incidence of salivary gland tumors in this group has increased each year, and this group accounted for 53.3% of the total cases over the past 10 years.Conclusion The number of patients with salivary gland tumors is increasing each year. The total incidence of salivary gland tumors is higher in men than in women. Large salivary gland tumors are mainly benign tumors, and small salivary gland tumors are more common. Polymorphic adenomas, Warthin tumors, and mucoepidermoid carcinomas are the most common tumor types; patients 40~60 years old are most likely to have benign salivary glands and have a high incidence of malignant tumors.

Key words: salivary gland; tumor; pleomorphic adenoma; Warthin tumor; mucoepidermoid carcinoma; adenoid cystic carcinoma; patholog; retrospective analysis

中图分类号: 

  • R78