口腔疾病防治 ›› 2020, Vol. 28 ›› Issue (7): 468-471.doi: 10.12016/j.issn.2096-1456.2020.07.012

• 综述 • 上一篇    下一篇

表没食子儿茶素-3-没食子酸酯预防和治疗口腔癌的研究进展

刘恩言,贺兵,李明云()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院,四川 成都(610041)
  • 收稿日期:2019-07-05 修回日期:2020-03-15 出版日期:2020-07-20 发布日期:2020-06-04
  • 通讯作者: 李明云 E-mail:limingyun@scu.edu.cn
  • 作者简介:刘恩言,本科,Email:liuenyanAPTX@163.com
  • 基金资助:
    国家自然科学基金青年项目(81400501);国家自然科学基金青年项目(81500811)

Research progress on epigallocatechin-3-gallate in the prevention and treatment of oral cancer

LIU Enyan,HE Bing,LI Mingyun()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-07-05 Revised:2020-03-15 Online:2020-07-20 Published:2020-06-04
  • Contact: Mingyun LI E-mail:limingyun@scu.edu.cn

摘要:

表没食子儿茶素-3-没食子酸酯(epigallocatechin-3-gallate,EGCG)具有抗菌、抗炎、抗肿瘤等多种作用,EGCG对于口腔癌的防治及其抗癌机制的探究是研究热点,本文就EGCG对于口腔癌的防治作用及其抗癌机制做一综述,研究显示,EGCG可以调控多条细胞代谢信号通路,如G蛋白偶联受体信号通路、丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路、Wnt信号通路,并且可以调控DNA甲基化与作用于口腔癌细胞的RNA中,直接或间接通过口腔癌细胞信号传导网络抑制口腔癌前病变及口腔癌的发生发展。EGCG与5-氟尿嘧啶联合应用能够增强疗效,降低副作用,有望作为预防和治疗口腔癌的新型药物。

关键词: 天然药物; 表没食子儿茶素-3-没食子酸酯; 口腔癌; 化疗; 预防; 口腔癌前状态; 口腔黏膜下纤维化; 信号通路; 作用机制; 5-氟尿嘧啶; 伐地那非

Abstract:

Epigallocatechin-3-gallate (EGCG) has antibacterial, anti-inflammatory, antitumor, and other functions. EGCG and its anticancer mechanism are hot research topics in the prevention and treatment of oral cancer. In this paper, the prevention and treatment effects of EGCG on oral cancer and its anticancer mechanism are reviewed. The results show that EGCG can regulate multiple cell metabolic signaling pathways, such as the G protein coupled receptor signaling pathway, mitogen-activated protein kinase (MAPK), and the Wnt signaling pathway, and it can regulate DNA methylation and act on RNA of oral cancer cells directly or indirectly through the oral cancer cell signal transduction network to inhibit the development of oral precancerous lesions and oral cancer. EGCG combined with 5-fluorouracil can enhance the curative effect and reduce adverse effects and is expected to be a new drug for the prevention and treatment of oral cancer.

Key words: natural medicine; epigallocatechin gallate; oral cancer; chemotherapy; prevention; oral precancerous state; oral submucous fibrosis; signal pathway; mechanism; 5-fluorouracil; valdenafilmechanism

中图分类号: 

  • R78