口腔疾病防治 ›› 2020, Vol. 28 ›› Issue (12): 796-800.DOI: 10.12016/j.issn.2096-1456.2020.12.008

• 综述 • 上一篇    下一篇

B细胞激活因子在牙周炎发生发展中的作用

张正1,2(),王左敏2()   

  1. 1.天津市口腔医院,天津市口腔功能重建重点实验室,南开大学口腔医院牙周科,天津(300041)
    2.首都医科大学 附属北京朝阳医院口腔科,北京(100020)
  • 收稿日期:2020-03-07 修回日期:2020-04-20 出版日期:2020-12-20 发布日期:2020-11-10
  • 通讯作者: 王左敏
  • 作者简介:张正,主治医师,博士研究生在读,Email:zhangzhdr@sina.com
  • 基金资助:
    国家自然科学基金项目(81870763)

Role of B cell activating factor in the development of periodontitis

ZHANG Zheng1,2(),WANG Zuomin2()   

  1. 1. Department of Periodontology, Tianjin Stomatological Hospital, Tianjin Key Laboratory of Oral Function Reconstruction, Nankai University, Tianjin 300041, China
    2. Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
  • Received:2020-03-07 Revised:2020-04-20 Online:2020-12-20 Published:2020-11-10
  • Contact: Zuomin WANG

摘要:

B细胞激活因子(B cell activating factor,BAFF)为B细胞的关键调节因子,针对BAFF的调控被认为是治疗多种免疫炎症性疾病的潜在靶标。牙周炎可促进局部和全身BAFF因子表达,同时BAFF已被证实能够加重牙周炎B细胞免疫反应和组织破坏过程。此外,BAFF还可激发CD4+T细胞免疫反应,并抑制调节性T细胞和M2型巨噬细胞免疫反应,进而改变多种免疫炎症性疾病的发病过程。然而,上述生物学效应是否为BAFF加重牙周炎的重要原因仍缺乏直接证据,亟待开展相关研究予以证实。本文将就BAFF在牙周炎发生和进展中的表达及作用进行综述,旨在为开展BAFF牙周致病机制研究提供理论依据。

关键词: 牙周炎, B细胞, B细胞激活因子, 免疫反应, 唾液, 龈沟液, 外周血, CD4+, 调节性T细胞, M2型巨噬细胞

Abstract:

B cell activating factor (BAFF) is the key regulator of B cells and is considered as a potential therapeutic target for immune inflammatory diseases. Periodontitis can promote local and systemic BAFF factor expression, whereas BAFF aggravates B cell immune responses and tissue destruction in periodontitis. In addition, BAFF also stimulates CD4+T cell response and inhibits regulatory T cell and M2 macrophage responses, thus changing the pathogenesis of a variety of immune inflammatory diseases. However, whether the biological effect mentioned above is an important mechanism by which BAFF aggravates periodontitis still lacks direct evidence and should be confirmed in future research. To provide a theoretical basis for the study of the pathogenic mechanism of BAFF, the expression and role of BAFF in periodontitis is reviewed in this article.

Key words: periodontitis, B cell, B cell activating factor, immune response, saliva, gingival crevicular fluid, peripheral blood, CD4+, regulatory T cell, M2 macrophage

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