口腔疾病防治 ›› 2022, Vol. 30 ›› Issue (5): 350-354.DOI: 10.12016/j.issn.2096-1456.2022.05.007

• 临床研究 • 上一篇    下一篇

硫酸羟氯喹治疗口腔扁平苔藓13例不良反应报告

林瑶(), 黄静, 薛晓娟, 张欢, 冯斌()   

  1. 军事口腔医学国家重点实验室 国家口腔疾病临床医学研究中心 陕西省口腔生物工程技术研究中心 第四军医大学口腔医院药剂科,陕西 西安(710032)
  • 收稿日期:2021-08-05 修回日期:2021-11-07 出版日期:2022-05-20 发布日期:2022-02-17
  • 通讯作者: 冯斌
  • 作者简介:林瑶,主管药师,硕士,Email: yaoyao526@163.com

Adverse drug reactions induced by hydroxychloroquine in the treatment of oral lichen planus: a report of 13 cases

LIN Yao(), HUANG Jing, XUE Xiaojuan, ZHANG Huan, FENG Bin()   

  1. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, School of Stomatology, the Fourth Military Medical University, Xi’an 710032, China
  • Received:2021-08-05 Revised:2021-11-07 Online:2022-05-20 Published:2022-02-17
  • Contact: FENG Bin

摘要:

目的 分析硫酸羟氯喹的药品不良反应(adverse drug reaction,ADR)报告,为安全用药提供参考依据。方法 分析某三甲医院2019年5月-2021年5月报告的硫酸羟氯喹ADR报告,对其年龄、用药原因、ADR发生时间、合并用药、ADR转归等进行统计分析。结果 13例报告中未见严重ADR报告,60岁以上患者占报告总体53.85%,且出现ADR的时间明显早于60岁以下患者。61.54%的ADR累及多器官,且46.15%报告中出现视神经毒性。结论 在使用硫酸羟氯喹治疗口腔扁平苔藓过程中应监测药品不良反应,需高度关注60岁以上用药人群,保障患者用药安全。

关键词: 硫酸羟氯喹, 口腔扁平苔藓, 药品不良反应, 视神经毒性, 视力筛查, 心脏毒性, 用药安全性, 药品说明书

Abstract:

Objective To analyze the adverse drug reaction(ADR) reports of hydroxychloroquine for clinical medication safety. Methods The ADR reports of hydroxychloroquine between May 2019 and May 2021 were analyzed. Age, reasons for drug use, time of ADR, combined drug use, and ADR outcomes were statistically analyzed. Results No severe ADR was reported. Patients over 60 years old accounted for 53.85% of the total cases, and the time of ADR appearance was significantly earlier among those under 60 years old. A total of 61.54% of ADRs were involved in multiple organs, and optic neurotoxicity was reported in 46.15% of cases. Conclusion In the treatment of oral lichen planus with hydroxychloroquine, adverse drug reactions should be monitored, and increased attention should be given to patients over 60 years old to ensure the safety of this medication.

Key words: hydroxychloroquine, oral mucosal disease, adverse-drug reaction, optic neurotoxicity, vision screening, cardiotoxicity, medication safety, package inserts of drug

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