口腔疾病防治 ›› 2022, Vol. 30 ›› Issue (5): 377-380.DOI: 10.12016/j.issn.2096-1456.2022.05.012

• 综述 • 上一篇    

含铜钛合金调控巨噬细胞极化的研究进展

娄静扬1(), 耿欣荣1, 高慧萌1, 范东阳2, 赵昕3, 王强4()   

  1. 1.中国医科大学口腔医学院,辽宁 沈阳(110002)
    2.中国医科大学口腔医学院·附属口腔医院综合科,辽宁 沈阳(110002)
    3.中国医科大学口腔医学院·附属口腔医院口腔修复学教研室,辽宁 沈阳(110002)
    4.中国医科大学口腔医学院·附属口腔医院口腔材料学教研室,辽宁 沈阳(110002)
  • 收稿日期:2021-03-27 修回日期:2021-04-09 出版日期:2022-05-20 发布日期:2022-02-17
  • 通讯作者: 王强
  • 作者简介:娄静扬,本科在读,Email: loujingyang77@163.com
  • 基金资助:
    辽宁省自然科学基金项目(2020-MS-150);中国医科大学大学生创新创业项目(S202010159057)

Research progress on Ti-Cu alloys regulating macrophage polarization

LOU Jingyang1(), GENG Xinrong1, GAO Huimeng1, FAN Dongyang2, ZHAO Xin3, WANG Qiang4()   

  1. 1. School and Hospital of Stomatology, China Medical University, Shenyang 110002, China
    2. Department of General Dentistry, School and Hospital of Stomatology, China Medical University, Shenyang 110002, China
    3. Department of Prosthodontics, School and Hospital of Stomatology, China Medical University, Shenyang 110002, China
    4. Department of Dental Materials, School and Hospital of Stomatology, China Medical University, Shenyang 110002, China
  • Received:2021-03-27 Revised:2021-04-09 Online:2022-05-20 Published:2022-02-17
  • Contact: WANG Qiang
  • Supported by:
    Natural Science Foundation Project of Liaoning Province(2020-MS-150);China Medical University Training Program of Innovation and Entrepreneurship for Undergraduates(S202010159057)

摘要:

含铜钛合金作为一种新型抗菌材料,具有良好的生物学性能和机械性能,有望广泛应用于临床骨外科和口腔种植等领域。巨噬细胞是合金植入人体后介导免疫反应的主要细胞,并且直接影响合金长期服役的稳定性。含铜钛合金由于铜的添加,赋予了合金抗菌性能,一方面促进巨噬细胞吞噬和杀灭细菌,另一方面促进巨噬细胞极化激活,表达多种细胞因子,引发体内炎症反应。然而,目前关于含铜钛合金调控巨噬细胞极化的类型尚无定论,铜离子调控巨噬细胞极化的机制仍未统一。本文对已发表的关于含铜钛合金调控巨噬细胞极化的研究进行总结,分别从材料类型、表面处理、加工方式和细胞的培养方式、培养密度等方面,对相关文献进行综述,并且对医用含铜钛合金的应用进行了展望,希望通过改变含铜钛合金的性能,如加工方式或表面处理等,调控巨噬细胞的极化方向,以期为医用含铜钛合金的设计及临床应用提供参考。

关键词: 巨噬细胞, 极化, M1型巨噬细胞, M2型巨噬细胞, 细胞因子, 含铜钛合金, 抗菌材料, 铜元素, 细菌感染, 免疫反应, 抗菌

Abstract:

As a new type of antibacterial material, copper-containing titanium alloys have good biological and mechanical properties and are expected to be widely used in clinical orthopedics and dental implants. Macrophages are the main cells that mediate the immune response after the alloy is implanted into the human body, and they directly affect the stability of the alloy in long-term service. Due to the addition of copper, the copper-containing titanium alloy gives the alloy antibacterial properties. On the one hand, this promotes the phagocytosis of macrophages and kills bacteria. On the other hand, copper promotes the polarization activation of macrophages, which then express a variety of cytokines and trigger inflammation in the body. However, at present, there is no definitive conclusion about the type of copper-containing titanium alloys that regulate the polarization of macrophages, and the mechanism of copper ions regulating the polarization of macrophages is still not fully clear. This article summarizes the published studies on the regulation of macrophage polarization by copper-containing titanium alloys and reviews the relevant literature in terms of material types, surface treatments, processing methods, cell culture methods, and culture density. The application of medical copper-containing titanium alloys has prospects. It is hoped that by changing the properties of copper-containing titanium alloys, such as the processing methods or surface treatments, the polarization direction of macrophages can be adjusted, with a view to the design and clinical application of medical copper-containing titanium alloys.

Key words: macrophage, polarization, M1 macrophage, M2 macrophage, cytokine, copper-containing titanium alloys, antibacterial material, cuprum, bacterial infection, immunoreaction, antibacterial

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