口腔疾病防治 ›› 2022, Vol. 30 ›› Issue (6): 433-437.DOI: 10.12016/j.issn.2096-1456.2022.06.008

• 综述 • 上一篇    下一篇

Axin2阳性细胞在牙周组织发育与再生中的作用

时彬冕(), 谢旭东(), 王骏()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周病科,四川 成都(610041)
  • 收稿日期:2021-12-01 修回日期:2021-12-31 出版日期:2022-06-20 发布日期:2022-04-15
  • 通讯作者: 谢旭东,王骏
  • 作者简介:时彬冕,医师,学士,Email: 1270457059@qq.com
  • 基金资助:
    国家自然科学基金项目(82071127);国家自然科学基金项目(81700980)

The role of Axin2+ cells in periodontal tissue development and regeneration

SHI Binmian(), XIE Xudong(), WANG Jun()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-12-01 Revised:2021-12-31 Online:2022-06-20 Published:2022-04-15
  • Contact: XIE Xudong, WANG Jun
  • Supported by:
    grants from National Natural Science Foundation of China(82071127);grants from National Natural Science Foundation of China(81700980)

摘要:

WNT信号通路作为进化中高度保守的信号通路,在牙周组织生长发育和损伤修复中发挥重要调控作用。Axin相关蛋白Axin2作为WNT信号通路的直接效应分子,可对WNT效应细胞进行良好标记。研究显示,牙周组织内Axin2阳性(Axin2+)细胞具有自我更新、复制及多向分化潜能。本文对Axin2+细胞在牙周组织发育过程中的时空分布,以及Axin2+细胞在牙周组织发育、再生和组织改建中的作用及其调控机制研究进展作一综述,以期为牙周组织再生提供新的思路。现有研究表明,Axin2+细胞是牙周组织发育的重要干细胞来源,Axin2+细胞在拔牙窝愈合、种植体骨整合、牙周组织改建和结合上皮再生中均发挥重要作用。Axin2+细胞的功能受到经典WNT信号通路的正向调控。然而,其他信号通路对Axin2+细胞的调控机制仍有待阐明。

关键词: WNT信号通路, Axin2, 牙周组织, 发育, 再生, 干细胞, 稳态, 细胞谱系示踪

Abstract:

As a highly conserved signal pathway in evolution, the WNT signaling pathway plays an essential role in periodontium growth, development and injury repair. The Axin-associated protein Axin2 is a direct effector molecule of the WNT signaling pathway and labels WNT-responsive cells well. Studies have shown that Axin2-positive (Axin2+) cells in the periodontium have the potential for self-renewal, replication and multidirectional differentiation. This article reviews the temporal and spatial distribution of Axin2+ cells in periodontal tissue development and the role and regulatory mechanism of Axin2+ cells in periodontal tissue development, regeneration and tissue remodeling to provide new ideas for periodontal tissue regeneration. The literature review showed that Axin2+ cells were the main cell source of periodontium development, and Axin2+ cells played essential roles in tooth extraction socket healing, implant osseointegration, periodontal tissue remodeling and junctional epithelium regeneration. The function of Axin2+ cells was positively regulated by the canonical WNT signaling pathway. However, the regulatory mechanisms of other signaling pathways on Axin2+ cells remain to be elucidated.

Key words: WNT signaling pathway, Axin2, periodontal tissues, development, regeneration, stem cell, homeostasis, celllineage tracing

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