纳米粒子在正畸釉质脱矿预防中的应用

doi:10.12016/j.issn.2096-1456.2022.06.010

口腔疾病防治 ›› 2022, Vol. 30 ›› Issue (6): 443-448.DOI: 10.12016/j.issn.2096-1456.2022.06.010

纳米粒子在正畸釉质脱矿预防中的应用

罗婷¹(), 颜家榕¹(), 花放¹^,²^,³(), 贺红¹^,²()

1.武汉大学口腔医学院口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室,湖北武汉（430079）
2.武汉大学口腔医院口腔正畸一科,湖北武汉（430079）
3.武汉大学口腔医院循证口腔医学中心,湖北武汉（430079）

收稿日期:2021-06-18 修回日期:2021-11-16 出版日期:2022-06-20 发布日期:2022-04-15
通讯作者: 花放,贺红
作者简介:罗婷,住院医师,八年制在读,Email： luo_ting@whu.edu.cn
共同第一作者,颜家榕,住院医师,博士在读,Email： yanjiarong@whu.edu.cn
基金资助:
国家自然科学基金(81901044);中华口腔医学会口腔正畸专委会青年人才科研基金(COS-B2021-08);武汉中青年医学骨干人才培养工程([2019]87)

Application of nanoparticles in preventing enamel demineralization during orthodontics

LUO Ting¹(), YAN Jiarong¹(), HUA Fang¹^,²^,³(), HE Hong¹^,²()

1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
2. Department of Orthodontics, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
3. Center for Evidence-Based Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China

Received:2021-06-18 Revised:2021-11-16 Online:2022-06-20 Published:2022-04-15
Contact: HUA Fang, HE Hong
Supported by:
grants from National Natural Science Foundation of China(81901044);Chinese Stomatological Association COS Basic Research Fund(COS-B2021-08);Wuhan Young and Middle-aged Medical Talents Training Program([2019]87)

摘要/Abstract

摘要：

牙釉质脱矿是正畸治疗最常见的不良反应之一。正畸矫治器影响口腔清洁能力,易导致菌斑堆积及口腔菌群失调,致龋菌产酸引起牙釉质脱矿,不仅影响美观,还可能危害口腔健康,是一个亟待解决的难题。纳米粒子（nanoparticles,NPs）通常指直径为1~100 nm的固体颗粒,理化性质独特,能为正畸釉质脱矿预防提供新策略。回顾相关文献,用于预防正畸釉质脱矿的NPs按其功能可分为抗菌、再矿化及载体型三类。应用NPs改性正畸粘接剂赋予其抗菌或再矿化性能的研究最多;也有研究利用NPs对正畸矫治器进行表面涂层或整体掺杂改性使其具备抗菌性能。上述两种方式的优势在于不依赖患者的依从性。此外,NPs改性的氟保护漆及负载抗菌或再矿化制剂的纳米载体可用于促进正畸患者的口腔保健,该途径能发挥持续预防作用,但依赖患者配合。研究显示,NPs的小尺寸效应可增强其性能,但可能存在一定安全性问题,且仍对改性后材料本身理化性能有一定的影响,这些问题还需进一步探索。虽然现有研究还存在一定局限性,但可预见,未来纳米粒子在正畸釉质脱矿的预防中有望发挥重要作用。

关键词: 纳米粒子, 纳米载体, 口腔正畸, 牙釉质脱矿, 白垩斑, 粘接剂, 矫治器, 口腔保健, 抗菌, 再矿化

Abstract:

Enamel demineralization is one of the most common adverse reactions to orthodontic treatment. The existence of orthodontic appliances affects oral hygiene maintenance, which easily leads to plaque accumulation and oral flora dysbiosis, and cariogenic bacteria produce acid to cause enamel demineralization. It not only affects aesthetics but may develop into caries and endanger oral health. Therefore, enamel demineralization has become an urgent problem. Nanoparticles generally refer to solid particles with diameters of 1 to 100 nm and have unique physicochemical properties that provide a new strategy for preventing enamel demineralization during orthodontics. Reviewing the relevant literature, nanoparticles used for the prevention of enamel demineralization in orthodontics may be classified into antibacterial, remineralization and carrier-type nanoparticles according to their functions. Most research was performed on the application of nanoparticles to modify orthodontic adhesives for enhancement of antibacterial or remineralization properties, but some studies also focused on the modification of orthodontic appliances with nanoparticles for surface coating or overall doping to provide antimicrobial properties. The advantage of these two approaches is that they are not dependent on patient compliance. Nanoparticle-modified fluoride varnishes and nanocarriers loaded with antimicrobial or remineralization agents may be used to promote oral health care in orthodontic patients, which have a sustained preventive effect but depend on the cooperation of the patient. It was indicated that the small size effect of nanoparticles provides better performance, but there may be certain safety issues, and there is still some influence on the physicochemical properties of the modified materials themselves. These issues must be further explored. Although there are some limitations in the current studies, nanoparticles are expected to play an important role in the prevention of enamel demineralization during orthodontics in the future.

Key words: nanoparticles, nano-carrier, orthodontics, enamel demineralization, white spot lesions, adhesive, appliance, oral health care, antibacterial, remineralization

中图分类号:

罗婷, 颜家榕, 花放, 贺红. 纳米粒子在正畸釉质脱矿预防中的应用[J]. 口腔疾病防治, 2022, 30(6): 443-448.

LUO Ting, YAN Jiarong, HUA Fang, HE Hong. Application of nanoparticles in preventing enamel demineralization during orthodontics[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2022, 30(6): 443-448.

参考文献 39

[1]	Song W, Ge S. Application of antimicrobial nanoparticles in dentistry[J]. Molecules, 2019, 24(6):1033. doi: 10.3390/molecules24061033. DOI URL
[2]	Mandall NA, Millett DT, Mattick CR, et al. Adhesives for fixed orthodontic brackets[J]. Cochrane Database Syst Rev, 2003, (2): CD002282. doi: 10.1002/14651858.CD002282. DOI
[3]	Noori AJ, Kareem F. The effect of magnesium oxide nanoparticles on the antibacterial and antibiofilm properties of glass-ionomer cement[J]. Heliyon, 2019, 5(10):e02568. doi: 10.1016/j.heliyon.2019.e02568. DOI
[4]	Enan ET, Hammad SM. Microleakage under orthodontic bands cemented with nano-hydroxyapatite-modified glass ionomer[J]. Angle Orthod, 2013, 83(6):981-986. doi: 10.2319/022013-147.1. DOI URL
[5]	Garcia P, Cardia M, Francisconi RS, et al. Antibacterial activity of glass ionomer cement modified by zinc oxide nanoparticles[J]. Microsc Res Tech, 2017, 80(5):456-461. doi: 10.1002/jemt.22814. DOI URL
[6]	Yassaei S, Nasr A, Zandi H, et al. Comparison of antibacterial effects of orthodontic composites containing different nanoparticles on Streptococcus mutans at different times[J]. Dental Press J Orthod, 2020, 25(2):52-60. doi: 10.1590/2177-6709.25.2.052-060.oar. DOI PMID
[7]	Moreira DM, Oei J, Rawls HR, et al. A novel antimicrobial orthodontic band cement with in situ-generated silver nanoparticles[J]. Angle Orthod, 2015, 85(2):175-183. doi: 10.2319/022314-127.1. DOI PMID
[8]	Degrazia FW, Leitune VC, Garcia IM, et al. Effect of silver nanoparticles on the physicochemical and antimicrobial properties of an orthodontic adhesive[J]. J Appl Oral Sci, 2016, 24(4):404-410. doi: 10.1590/1678-775720160154. DOI URL
[9]	Eslamian L, Borzabadi-Farahani A, Karimi S, et al. Evaluation of the shear bond strength and antibacterial activity of orthodontic adhesive containing silver nanoparticle, an in-vitro study[J]. Nanomaterials (Basel), 2020, 10(8):1466. doi: 10.3390/nano10081466. DOI URL
[10]	Sodagar A, Akhavan A, Hashemi E, et al. Evaluation of the antibacterial activity of a conventional orthodontic composite containing silver/hydroxyapatite nanoparticles[J]. Prog Orthod, 2016, 17(1):40. doi: 10.1186/s40510-016-0153-x. DOI PMID
[11]	Sodagar A, Akhoundi M, Bahador A, et al. Effect of TiO2 nanoparticles incorporation on antibacterial properties and shear bond strength of dental composite used in orthodontics[J]. Dental Press J Orthod, 2017, 22(5):67-74. doi: 10.1590/2177-6709.22.5.067-074.oar. DOI PMID
[12]	Pourhajibagher M, Salehi VA, Takzaree N, et al. Physico-mechanical and antimicrobial properties of an orthodontic adhesive containing cationic curcumin doped zinc oxide nanoparticles subjected to photodynamic therapy[J]. Photodiagnosis Photodyn Ther, 2019, 25:239-246. doi: 10.1016/j.pdpdt.2019.01.002. DOI PMID
[13]	Mirhashemi A, Bahador A, Kassaee M, et al. Antimicrobial effect of nano-zinc oxide and nano-chitosan particles in dental composite used in orthodontics[J]. J Med Bacteriol, 2013, 2(3/4):1-10.
[14]	Przybyłek I, Karpiński TM. Antibacterial properties of propolis[J]. Molecules, 2019, 24(11):2047. doi: 10.3390/molecules24112047. DOI URL
[15]	Sodagar A, Akhavan A, Arab S, et al. Evaluation of the effect of propolis nanoparticles on antimicrobial properties and shear bond strength of orthodontic composite bonded to bovine enamel[J]. Front Dent, 2019, 16(2):96-104. doi: 10.18502/fid.v16i2.1360. DOI
[16]	Yi J, Weir MD, Melo MS, et al. Novel rechargeable nano-CaF2 orthodontic cement with high levels of long-term fluoride release[J]. J Dent, 2019, 90:103214. doi: 10.1016/j.jdent. 2019.103214. DOI
[17]	Khoroushi M, Kachuie M. Prevention and treatment of white spot lesions in orthodontic patients[J]. Contemp Clin Dent, 2017, 8(1):11-19. doi: 10.4103/ccd.ccd_216_17. DOI URL
[18]	Asiry MA, Alshahrani I, Alqahtani ND, et al. Efficacy of yttrium (III) fluoride nanoparticles in orthodontic bonding[J]. J NanosciNanotechnol, 2019, 19(2):1105-1110. doi: 10.1166/jnn.2019.15894. DOI
[19]	Xie XJ, Xing D, Wang L, et al. Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement[J]. Int J Oral Sci, 2017, 9(1):24-32. doi: 10.1038/ijos.2016.40. DOI URL
[20]	Liu Y, Zhang L, Niu LN, et al. Antibacterial and remineralizing orthodontic adhesive containing quaternary ammonium resin monomer and amorphous calcium phosphate nanoparticles[J]. J Dent, 2018, 72(72):53-63. doi: 10.1016/j.jdent.2018.03.004. DOI URL
[21]	Wang X, Wang B, Wang Y. Antibacterial orthodontic cement to combat biofilm and white spot lesions[J]. Am J Orthod Dentofacial Orthop, 2015, 148(6):974-981. doi: 10.1016/j.ajodo.2015.06.017. DOI URL
[22]	Zaltsman N, Kesler SD, Polak D, et al. Antibacterial orthodontic adhesive incorporating polyethyleneimine nanoparticles[J]. Oral Health Prev Dent, 2017, 15(3):245-250. doi: 10.3290/j.ohpd.a38525. DOI
[23]	Yi J, Dai Q, Weir MD, et al. A nano-CaF2-containing orthodontic cement with antibacterial and remineralization capabilities to combat enamel white spot lesions[J]. J Dent, 2019, 89:103172.doi: 10.1016/j.jdent.2019.07.010. DOI
[24]	Ma Y, Zhang N, Weir MD, et al. Novel multifunctional dental cement to prevent enamel demineralization near orthodontic brackets[J]. J Dent, 2017, 64:58-67. doi: 10.1016/j.jdent.2017.06.004. DOI URL
[25]	Kachoei M, Nourian A, Divband B, et al. Zinc-oxide nanocoating for improvement of the antibacterial and frictional behavior of nickel-titanium alloy[J]. Nanomedicine (Lond), 2016, 11(19):2511-2527. doi: 10.2217/nnm-2016-0171. DOI URL
[26]	Venkatesan K, Kailasam V, Padmanabhan S. Evaluation of titanium dioxide coating on surface roughness of nickel-titanium archwires and its influence on Streptococcus mutans adhesion and enamel mineralization: a prospective clinical study[J]. Am J Orthod Dentofacial Orthop, 2020, 158(2):199-208. doi: 10.1016/j.ajodo.2019.07.019. DOI URL
[27]	Cao B, Wang Y, Li N, et al. Preparation of an orthodontic bracket coated with an nitrogen-doped TiO(2-x)N(y)thin film and examination of its antimicrobial performance[J]. Dent Mater J, 2013, 32(2):2012-2155.
[28]	Salehi P, Babanouri N, Roein-Peikar M, et al. Long-term antimicrobial assessment of orthodontic brackets coated with nitrogen-doped titanium dioxide against Streptococcus mutans[J]. Prog Orthod, 2018, 19(1):35. doi: 10.1186/s40510-018-0236-y. DOI URL
[29]	Metin-Gürsoy G, Taner L, Akca G. Nanosilver coated orthodontic brackets: in vivo antibacterial properties and ion release[J]. Eur J Orthod, 2017, 39(1):9-16. doi: 10.1093/ejo/cjv097. DOI URL
[30]	Prabha RD, Kandasamy R, Sivaraman US, et al. Antibacterial nanosilver coated orthodontic bands with potential implications in dentistry[J]. Indian J Med Res, 2016, 144(4):580-586. doi: 10.4103/0971-5916.200895. DOI
[31]	Hernández-Gómora AE, Lara-Carrillo E, Robles-Navarro JB, et al. Biosynjournal of silver nanoparticles on orthodontic elastomeric modules: evaluation of mechanical and antibacterial properties[J]. Molecules, 2017, 22(9):1407. doi: 10.3390/molecules22091407. DOI URL
[32]	Farhadian N, Usefi MR, Khanizadeh S, et al. Streptococcus mutans counts in patients wearing removable retainers with silver nanoparticles vs those wearing conventional retainers: a randomized clinical trial[J]. Am J Orthod Dentofacial Orthop, 2016, 149(2):155-160. doi: 10.1016/j.ajodo.2015.07.031. DOI URL
[33]	Perrini F, Lombardo L, Arreghini A, et al. Caries prevention during orthodontic treatment: in-vivo assessment of high-fluoride varnish to prevent white spot lesions[J]. Am J Orthod Dentofacial Orthop, 2016, 149(2):238-243. doi: 10.1016/j.ajodo.2015.07.039. DOI URL
[34]	Targino AG, Flores MA, Dos Santos Junior VE, et al. An innovative approach to treating dental decay in children. A new anti-caries agent[J]. J Mater Sci Mater Med, 2014, 25(8):2041-2047. doi: 10.1007/s10856-014-5221-5. DOI URL
[35]	Wassel MO, Khattab MA. Antibacterial activity against Streptococcus mutans and inhibition of bacterial induced enamel demineralization of propolis, miswak, and chitosan nanoparticles based dental varnishes[J]. J Adv Res, 2017, 8(4):387-392. doi: 10.1016/j.jare.2017.05.006. DOI URL
[36]	Liu Y, Ren Y, Li Y, et al. Nanocarriers with conjugated antimicrobials to eradicate pathogenic biofilms evaluated in murine in vivo and human ex vivo infection models[J]. Acta Biomater, 2018, 79(79):331-343. doi: 10.1016/j.actbio.2018.08.038. DOI URL
[37]	He J, Bao Y, Li J, et al. Nanocomplexes of carboxymethyl chitosan/amorphous calcium phosphate reduce oral bacteria adherence and biofilm formation on human enamel surface[J]. J Dent, 2019, 80:15-22. doi: 10.1016/j.jdent.2018.11.003. DOI URL
[38]	Zhu Y, Yan J, Mujtaba BM, et al. The dual anti-caries effect of carboxymethyl chitosan nanogel loaded with chimeric lysin ClyR and amorphous calcium phosphate[J]. Eur J Oral Sci, 2021, 129(3):e12784. doi: 10.1111/eos.12784. DOI
[39]	谢琳, 冯晓黎, 邓梓, 等. 口腔纳米材料的神经毒性及作用机制[J]. 口腔疾病防治, 2020, 28(9):594-599. doi: 10.12016/j.issn.2096-1456.2020.09.009. DOI
	Xie L, Feng XL, Deng Z, et al. Neurotoxicity and mechanism of dental nanomaterials[J]. J Prev Treat Stomatol Dis, 2020, 28(9):594-599. doi: 10.12016/j.issn.2096-1456.2020.09.009. DOI

纳米粒子在正畸釉质脱矿预防中的应用

Application of nanoparticles in preventing enamel demineralization during orthodontics

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 39

相关文章 15

编辑推荐

Metrics

[1]	邹蓉芳, 赖璇, 邓斌. 氮化硅陶瓷在牙科种植体方向的应用前景[J]. 口腔疾病防治, 2022, 30(6): 449-452.
[2]	陈宥任, 罗云, 王敏, 郝亮, 岳源. Er: YAG激光在拆除全瓷修复体中应用的研究进展[J]. 口腔疾病防治, 2022, 30(5): 372-376.
[3]	娄静扬, 耿欣荣, 高慧萌, 范东阳, 赵昕, 王强. 含铜钛合金调控巨噬细胞极化的研究进展[J]. 口腔疾病防治, 2022, 30(5): 377-380.
[4]	邓文振, 田徐腾越, 李雪微, 董伟, 梁永强. 醋酸氯己定复合介孔二氧化硅改性正畸粘接树脂的体外研究[J]. 口腔疾病防治, 2022, 30(3): 178-184.
[5]	郭宏磊, 张凯, 张旭. 甘氨酸引导羧甲基壳聚糖/无定形磷酸钙再矿化脱矿牙釉质表面的研究[J]. 口腔疾病防治, 2022, 30(2): 83-88.
[6]	许屹立, 于皓. 通用型粘接剂对牙体组织粘接效果影响因素的研究进展[J]. 口腔疾病防治, 2022, 30(1): 68-72.
[7]	张新坚, 张斌. 纳米粒子递药系统在牙周炎局部药物治疗中应用的研究进展[J]. 口腔疾病防治, 2022, 30(1): 73-76.
[8]	黄彦楠,程磊. 纳米磷酸钙盐改性牙科材料防治牙体牙髓病研究进展[J]. 口腔疾病防治, 2021, 29(9): 634-637.
[9]	周泽瑛,张静月,牛菊,刘丹丹,赵文迪,刘晓秋. 牙科树脂材料抗菌性能的研究进展[J]. 口腔疾病防治, 2021, 29(9): 638-643.
[10]	王珏,王倩,吴佳,李凌锋,隋欣,李美慧,张骁,高颖,杨柳青,刘志辉. 牙本质和牙骨质的仿生修复与再生[J]. 口腔疾病防治, 2021, 29(6): 422-427.
[11]	齐霞,孔令雪,李淑娟,马思婷,齐雅丽,赵蕾. 表没食子儿茶素没食子酸酯对牙龈卟啉单胞菌细菌毒力抑制作用的体外研究[J]. 口腔疾病防治, 2021, 29(5): 314-321.
[12]	范东阳,王强,周怡君,李斯文,冯旭,刘春冉,崔家森,孙宏晨. 抗菌钛合金在口腔医学中应用研究进展[J]. 口腔疾病防治, 2021, 29(4): 284-288.
[13]	王天琦,杜青,谢伟丽. 钛表面微弧氧化-微波水热法铜铌涂层的制备及抗菌性研究[J]. 口腔疾病防治, 2021, 29(11): 733-739.
[14]	张雅萌,张惠媛,阮世红,陈晓春,甘雪琦,于海洋. 中老年2型糖尿病牙周炎患者龈沟液抗菌肽水平及其与牙周临床指标的相关性[J]. 口腔疾病防治, 2021, 29(11): 746-751.
[15]	徐腾飞,陈斌,敖慧芝,孙卫斌,吴文蕾. 抗菌光动力疗法对2型糖尿病牙周炎患者牙周治疗效果和血糖控制影响的系统评价与Meta分析[J]. 口腔疾病防治, 2021, 29(11): 752-760.