口腔疾病防治 ›› 2022, Vol. 30 ›› Issue (7): 523-527.DOI: 10.12016/j.issn.2096-1456.2022.07.010

• 综述 • 上一篇    下一篇

OX40/OX40L轴介导T细胞免疫参与口腔扁平苔藓病程的研究进展

刘洋(), 王兴, 张妮, 张芳()   

  1. 山西医科大学口腔医学院·口腔医院,山西 太原(030001)
  • 收稿日期:2021-04-18 修回日期:2021-06-17 出版日期:2022-07-20 发布日期:2022-04-25
  • 通讯作者: 张芳
  • 作者简介:刘洋,医师,硕士研究生,Email: 2857055140@qq.com
  • 基金资助:
    国家自然科学基金项目(82071155);山西医科大学口腔医院科研基金项目(KY201913)

Research progress on OX40/OX40L axis mediated T cell immunity in the course of oral lichen planus

LIU Yang(), WANG Xing, ZHANG Ni, ZHANG Fang()   

  1. Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, China
  • Received:2021-04-18 Revised:2021-06-17 Online:2022-07-20 Published:2022-04-25
  • Contact: ZHANG Fang
  • Supported by:
    National Natural Science Foundation of China(82071155);Scientific Research Fund Project of Stomatological Hospital of Shanxi Medical University(KY201913)

摘要:

口腔扁平苔藓(oral lichen planus,OLP)是一种发病机制尚不明确的、常见的口腔黏膜慢性疾病。T细胞的局部浸润在其病理过程中起关键作用。越来越多的研究支持辅助性T细胞(helper T cell,Th)如Th1/Th2、Th17/调节T细胞(regulatory T cells,Treg)及其相关细胞因子的失衡与OLP的发病进展密切相关。近年来研究显示,共刺激分子OX40(CD134)及其配体OX40L(CD252)在T细胞免疫应答过程中具有重要意义而受到关注,参与Th1/Th2、Th17/Treg的平衡调控,介导促炎和抗炎的失衡,影响多种自身免疫性疾病的发生发展。但目前缺乏OX40/OX40L轴介导OLP发病过程中T细胞亚群失衡作用机制的研究。因此,未来仍需要针对OX40/OX40L轴调控OLP中T细胞亚群平衡机制开展大样本的临床和体内外实验研究。

关键词: 辅助性T细胞, 共刺激分子, OX40/OX40L, 口腔扁平苔藓, 免疫学机制, 细胞因子, T细胞亚群, 免疫治疗, 靶向治疗

Abstract:

Oral lichen planus (OLP) is a common chronic disease of the oral mucosa with unclear pathogenesis. Local infiltration of T cells plays a key role in the pathological process of OLP. Increased evidence supports the notion that the imbalance of helper T cells (Th) 1/Th2 and Th17/regulatory T cells (Treg) and their related cytokines is closely related to the pathogenesis and progression of OLP. In recent years, studies have shown that OX40 (CD134) and its ligand OX40L (CD252) play an important role in the process of the T-cell immune response. They participate in the balance regulation of Th1/Th2 and Th17/Treg, mediate the imbalance of pro-inflammatory and anti-inflammatory, and affect the occurrence and development of a variety of autoimmune diseases. However, there is no direct evidence that the OX40/OX40L axis mediates the imbalance of T-cell subsets in the pathogenesis of OLP. Therefore, large sample clinical as well as in vitro and in vivo experimental studies on the mechanism by which the OX40/OX40L axis regulates the balance of T-cell subsets in OLP are still needed in the future.

Key words: helper T cells, costimulatory molecules, OX40/OX40L, oral lichen planus, immunological mechanism, cytokines, T cell subsets, immunotherapy, targeted therapy

中图分类号: