口腔疾病防治 ›› 2022, Vol. 30 ›› Issue (8): 594-599.DOI: 10.12016/j.issn.2096-1456.2022.08.010
收稿日期:
2021-05-23
修回日期:
2021-07-14
出版日期:
2022-08-20
发布日期:
2022-05-09
通讯作者:
林晓萍
作者简介:
张耀月,硕士研究生,Email: 2420708050@qq.com
基金资助:
ZHANG Yaoyue(), LIN Xiaoping(
)
Received:
2021-05-23
Revised:
2021-07-14
Online:
2022-08-20
Published:
2022-05-09
Contact:
LIN Xiaoping
Supported by:
摘要:
牙周炎是由牙菌斑生物膜引起的牙周组织丧失的慢性感染性疾病。动脉粥样硬化是以脂质堆积为特征,发生在动脉壁的慢性炎症性疾病。近年来大量研究表明牙周炎和动脉粥样硬化之间存在一定的联系。从流行病学角度分析,发现牙周炎患者的动脉粥样硬化发病率更高;Th17分泌的白细胞介素17(interleukin-17,IL-17)通过促使基质金属蛋白酶含量升高,破坏结缔组织,加重两种疾病的进展;Treg细胞通过分泌抑炎因子和表达共抑制因子,降低T细胞活化,限制炎症发展;通过牙周干预治疗可以降低动脉粥样硬化中炎症标记物,有助于动脉粥样硬化的治疗。虽然多项研究结果表明牙周炎和动脉粥样硬化两者可相互影响,但仍需进一步的研究来明确牙周炎和动脉粥样硬化之间相互作用的具体机制。
中图分类号:
张耀月, 林晓萍. Th17/Treg细胞在牙周炎与动脉粥样硬化发病中的作用及牙周干预治疗的相关研究[J]. 口腔疾病防治, 2022, 30(8): 594-599.
ZHANG Yaoyue, LIN Xiaoping. The functions of Th17/Treg cells and relevant studies on the treatment of periodontitis and atherosclerosis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2022, 30(8): 594-599.
[1] |
Batool H, Nadeem A, Kashif M, et al. Salivary levels of IL-6 and IL-17 could be an indicator of disease severity in patients with calculus associated chronic periodontitis[J]. Biomed Res Int, 2018: 8531961. doi: 10.1155/2018/8531961.
DOI |
[2] |
Damgaard C, Reinholdt J, Enevold C, et al. Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis[J]. J Oral Microbiol, 2017, 9(1): 1374154. doi: 10.1080/20002297.2017.1374154.
DOI URL |
[3] |
Yagnik K, Mahendra J, Kurian VM. The Periodontal-cardiovascular alliance: evaluation of miRNA-146a in subgingival plaque samples of chronic periodontitis patients with and without coronary heart disease[J]. J Investig Clin Dent, 2019, 10(4): e12442. doi: 10.1111/jicd.12442.
DOI |
[4] |
Mantani PT, Vallejo J, Ljungcrantz I, et al. Interleukin-25 reduces Th17 cells and inflammatory responses in human peripheral blood mononuclear cells[J]. Hum Immunol, 2018, 79(9): 685-692. doi: 10.1016/j.humimm.2018.06.008.
DOI URL |
[5] |
Hu W, Wei R, Wang LY, et al. Correlations of MMP-1, MMP-3, and MMP-12 with the degree of atherosclerosis, plaque stability and cardiovascular and cerebrovascular events[J]. Exp Ther Med, 2018, 15(2): 1994-1998. doi: 10.3892/etm.2017.5623.
DOI PMID |
[6] |
Belinga LEE, Ngan WB, Lemougoum D, et al. Association between periodontal diseases and cardiovascular diseases in Cameroon[J]. J Public Health Africa, 2018, 9(1): 761. doi: 10.4081/jphia.2018.761.
DOI |
[7] |
Ljunggren S, Bengtsson T, Karlsson H, et al. Modified lipoproteins in periodontitis: a Link to cardiovascular disease?[J]. Biosci Rep, 2019, 39(3): BSR20181665. doi: 10.1042/BSR20181665.
DOI URL |
[8] |
Roth GA, Johnson C, Abajobir AA, et al. Global, regional, and National burden of cardiovascular diseases for 10 causes, 1990 to 2015[J]. J Am Coll Cardiol, 2017, 70(1): 1-25. doi: 10.1016/j.jacc.2017.04.052.
DOI URL |
[9] |
Sharma M, Schlegel MP, Afonso MS, et al. Regulatory T cells license macrophage pro-resolving functions during atherosclerosis regression[J]. Circ Res, 2020, 127(3): 335-353. doi: 10.1161/CIRCRESAHA.119.316461.
DOI URL |
[10] |
Byon MJ, Kim SY, Kim JS, et al. Association of periodontitis with atherosclerotic cardiovascular diseases: a nationwide population-based retrospective matched cohort study[J]. Int J Environ Res Public Health, 2020, 17(19): 7261. doi: 10.3390/ijerph17197261.
DOI URL |
[11] |
Beukers NG, Van Der Heijden GJ, Van Wijk AJ, et al. Periodontitis is an Independent risk indicator for atherosclerotic cardiovascular diseases among 60 174 participants in a large dental school in the Netherlands[J]. J Epidemiol Community Health, 2017, 71(1): 37-42.
DOI URL |
[12] |
Beukers N, Su N, Loos BG, et al. Lower number of teeth is related to higher risks for ACVD and death-systematic review and meta-analyses of survival data[J]. Front Cardiovasc Med, 2021, 8: 621626. doi: 10.3389/fcvm.2021.621626.
DOI URL |
[13] |
Fujitani T, Aoyama N, Hirata F, et al. Association between periodontitis and vascular endothelial function using noninvasive medical device-a pilot study[J]. Clin Exp Dent Res, 2020, 6(5): 576-582. doi: 10.1002/cre2.312.
DOI URL |
[14] |
Tang X. Analysis of interleukin-17 and interleukin-18 levels in animal models of atherosclerosis[J]. Exp Ther Med, 2019, 18(1): 517-522. doi: 10.3892/etm.2019.7634.
DOI |
[15] |
Jayakumar SV, Sadasivan A, Koshi E, et al. Effect of NonSurgical periodontal therapy on plasma levels of IL-17 in chronic periodontitis patients with well controlled type-II diabetes mellitus-a clinical study[J]. Dent J(Basel), 2018, 6(2): 19. doi: 10.3390/dj6020019.
DOI |
[16] |
Ge N, Peng J, Yu L, et al. Orthodontic treatment induces Th17/Treg cells to regulate tooth movement in rats with periodontitis[J]. Iran J Basic Med Sci, 2020, 23(10): 1315-1322. doi: 10.22038/ijbms.2020.44437.10419.
DOI |
[17] |
Bunte K, Beikler T. Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases[J]. Int J Mol Sci, 2019, 20(14): 3394. doi: 10.3390/ijms20143394.
DOI |
[18] |
Medara N, Lenzo JC, Walsh KA, et al. T helper 17 cell-related cytokines in serum and saliva during management of periodontitis[J]. Cytokine, 2020, 134: 155186. doi: 10.1016/j.cyto.2020.155186.
DOI URL |
[19] |
Yu JJ, Ruddy MJ, Wong GC, et al. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals[J]. Blood, 2007, 109(9): 3794-3802. doi: 10.1182/blood-2005-09-010116.
DOI URL |
[20] |
Yazdani MR, Khosropanah S, Doroudchi M. Interleukin-17 production by CD4+CD45RO+Foxp3+ T cells in peripheral blood of patients with atherosclerosis[J]. Arch Med Sci Atheroscler Dis, 2019, 4(4): e215-e224. doi: 10.5114/amsad.2019.87525.
DOI |
[21] |
Da Motta R, Almeida LY, Villafuerte K, et al. FOXP3+and CD25+cells are reduced in patients with stage IV,grade C periodontitis: a comparative clinical study[J]. J Periodontal Res, 2020, 55(3): 374-380. doi: 10.1111/jre.12721.
DOI URL |
[22] |
Inönü E, Kayis SA, Eskan MA, et al. Salivary Del-1, IL-17, and LFA-1 levels in periodontal health and disease[J]. J Periodontal Res, 2020, 55(4): 511-518. doi: 10.1111/jre.12738.
DOI PMID |
[23] |
Wang Z, Wei Y, Lei L, et al. RANKL expression of primary osteoblasts is enhanced by an IL-17-mediated JAK2/STAT3 pathway through autophagy suppression[J]. Connect Tissue Res, 2020: 1-16. doi: 10.1080/03008207.2020.1759562.
DOI |
[24] |
Rajendran M, Looney S, Singh N, et al. Systemic antibiotic therapy reduces circulating inflammatory dendritic cells and Treg-Th17 plasticity in periodontitis[J]. J Immunol, 2019, 202(9): 2690-2699. doi: 10.4049/jimmunol.1900046.
DOI URL |
[25] |
Wolf D, Gerhardt T, Winkels H, et al. Pathogenic autoimmunity in atherosclerosis evolves from initially protective apolipoprotein B(100)-Reactive CD4(+) T-Regulatory cells[J]. Circulation, 2020, 142(13): 1279-1293. doi: 10.1161/CIRCULATIONAHA.119.042863.
DOI URL |
[26] |
Mueller PA, Zhu L, Tavori H, et al. Deletion of macrophage Low-Density lipoprotein Receptor-Related protein 1 (LRP1) accelerates atherosclerosis regression and increases C-C chemokine receptor type 7 (CCR7) expression in plaque macrophages[J]. Circulation, 2018, 138(17): 1850-1863. doi: 10.1161/CIRCULATIONAHA.117.031702.
DOI PMID |
[27] |
Gao L, Zhao Y, Wang P, et al. Detection of Th17/Treg cells and related factors in gingival tissues and peripheral blood of rats with experimental periodontitis[J]. Iran J Basic Med Sci, 2017, 20(3): 294-300. doi: 10.22038/ijbms.2017.8359.
DOI PMID |
[28] |
Yang J, Wu J, Zhang R, et al. Porphyromonas gingivalis oral infection promote T helper 17/Treg imbalance in the development of atherosclerosis[J]. J Dent Sci, 2016, 12(1): 60-69. doi: 10.1016/j.jds.2016.10.003.
DOI URL |
[29] |
Wang L, Wang J, Jin Y, et al. Oral administration of all-trans retinoic acid suppresses experimental periodontitis by modulating the Th17/Treg imbalance[J]. J Periodontol, 2014, 85(5): 740-750. doi: 10.1902/jop.2013.130132.
DOI URL |
[30] |
Fan Q, Liu Y, Rao J, et al. Anti-Atherosclerosis effect of angong niuhuang pill via regulating Th17/Treg immune balance and inhibiting chronic inflammatory on ApoE(-/-) mice model of early and mid-term atherosclerosis[J]. Front Pharmacol, 2019, 10: 1584. doi: 10.3389/fphar.2019.01584.
DOI URL |
[31] |
Gürsoy UK, Könönen E, Tervahartiala T, et al. Molecular forms and fragments of salivary MMP-8 in relation to periodontitis[J]. J Clin Periodontol, 2018, 45(12): 1421-1428. doi: 10.1111/jcpe.13024.
DOI PMID |
[32] |
Lotfy H, Moaaz M, Moaaz M. The novel role of IL-37 to enhance the anti-inflammatory response of regulatory T cells in patients with peripheral atherosclerosis[J]. Vascular, 2020, 28(5): 629-642. doi: 10.1177/1708538120921735.
DOI URL |
[33] |
Sun L, Girnary M, Wang L, et al. IL-10 dampens an IL-17-mediated periodontitis-associated inflammatory network[J]. J Immunol, 2020, 204(8): 2177-2191. doi: 10.4049/jimmunol.1900532.
DOI PMID |
[34] |
Wang G, Xu B, Shi F, et al. Protective effect of methane-rich saline on acetic acid-induced ulcerative colitis via blocking the TLR4/NF-κB/MAPK pathway and promoting IL-10/JAK1/STAT3-mediated anti-inflammatory response[J]. Oxid Med Cell Longev, 2019: 7850324. doi: 10.1155/2019/7850324.
DOI |
[35] |
Lan HY. Diverse roles of TGF-β/Smads in renal fibrosis and inflammation[J]. Int J Biol Sci, 2011, 7(7): 1056-1067. doi: 10.7150/ijbs.7.1056.
DOI URL |
[36] |
Nakane S, Imamura K, Hisanaga R, et al. Systemic administration of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)-Ig abrogates alveolar bone resorption in induced periodontitis through inhibition of osteoclast differentiation and activation: an experimental investigation[J]. J Periodontal Res, 2021, 56(5): 972-981. doi: 10.1111/jre.12909.
DOI URL |
[37] |
Poels K, Van LM, Reiche ME, et al. Antibody-Mediated inhibition of CTLA4 aggravates atherosclerotic plaque inflammation and progression in hyperlipidemic mice[J]. Cells, 2020, 9(9): 1987. doi: 10.3390/cells9091987.
DOI |
[38] |
Park SY, Kim SH, Kang SH, et al. Improved oral hygiene care attenuates the cardiovascular risk of oral health disease: a population-based study from Korea[J]. Eur Heart J, 2019, 40(14): 1138-1145. doi: 10.1093/eurheartj/ehy836.
DOI URL |
[39] |
Kudo C, Shin WS, Sasaki N, et al. Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study[J]. Odontology, 2018, 106(3): 316-327. doi: 10.1007/s10266-017-0331-4.
DOI URL |
[40] |
Wang MM, Zhao Y, Wang C, et al. Effects of periodontal intervention on levels of serum high-sensitivity c-reactive protein and interleukin 6, and on carotid artery in rats with chronic periodontitis and hyperlipidemia[J]. Chin J Dent Res, 2019, 22(3): 203-209. doi: 10.3290/j.cjdr.a43115.
DOI |
[41] |
Sanz M, Del Castillo AM, Jepsen S, et al. Periodontitis and cardiovascular diseases. consensus report[J]. Glob Heart, 2020, 15(1): 1. doi: 10.5334/gh.400.
DOI PMID |
[42] |
Teeuw WJ, Slot DE, Susanto H, et al. Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis[J]. J Clin Periodontol, 2014, 41(1): 70-79. doi: 10.1111/jcpe.12171.
DOI URL |
[43] |
Czesnikiewicz-Guzik M, D'aiuto F, Deanfield JE. Understanding residual inflammatory risk sheds new light on the clinical importance of periodontitis in cardiovascular disease[J]. Eur Heart J, 2020, 41(7): 818-819. doi: 10.1093/eurheartj/ehaa107.
DOI PMID |
[44] |
Saffi M, Rabelo-Silva E, Polanczyk CA, et al. Periodontal therapy and endothelial function in coronary artery disease: a randomized controlled trial[J]. Oral Dis, 2018, 24(7): 1349-1357. doi: 10.1111/odi.12909.
DOI URL |
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