口腔疾病防治 ›› 2022, Vol. 30 ›› Issue (8): 594-599.DOI: 10.12016/j.issn.2096-1456.2022.08.010

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Th17/Treg细胞在牙周炎与动脉粥样硬化发病中的作用及牙周干预治疗的相关研究

张耀月(), 林晓萍()   

  1. 中国医科大学附属盛京医院口腔科,辽宁 沈阳(110004)
  • 收稿日期:2021-05-23 修回日期:2021-07-14 出版日期:2022-08-20 发布日期:2022-05-09
  • 通讯作者: 林晓萍
  • 作者简介:张耀月,硕士研究生,Email: 2420708050@qq.com
  • 基金资助:
    国家自然科学基金项目(81570988);中华口腔医学会专项基金研究项目(CSA-Z2015-07)

The functions of Th17/Treg cells and relevant studies on the treatment of periodontitis and atherosclerosis

ZHANG Yaoyue(), LIN Xiaoping()   

  1. Department of Stomatology, Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Received:2021-05-23 Revised:2021-07-14 Online:2022-08-20 Published:2022-05-09
  • Contact: LIN Xiaoping
  • Supported by:
    National Natural Science Foundation of China(81570988);Special Foundation of Chinese Stomatological Association(CSA-Z2015-07)

摘要:

牙周炎是由牙菌斑生物膜引起的牙周组织丧失的慢性感染性疾病。动脉粥样硬化是以脂质堆积为特征,发生在动脉壁的慢性炎症性疾病。近年来大量研究表明牙周炎和动脉粥样硬化之间存在一定的联系。从流行病学角度分析,发现牙周炎患者的动脉粥样硬化发病率更高;Th17分泌的白细胞介素17(interleukin-17,IL-17)通过促使基质金属蛋白酶含量升高,破坏结缔组织,加重两种疾病的进展;Treg细胞通过分泌抑炎因子和表达共抑制因子,降低T细胞活化,限制炎症发展;通过牙周干预治疗可以降低动脉粥样硬化中炎症标记物,有助于动脉粥样硬化的治疗。虽然多项研究结果表明牙周炎和动脉粥样硬化两者可相互影响,但仍需进一步的研究来明确牙周炎和动脉粥样硬化之间相互作用的具体机制。

关键词: 牙周炎, 动脉粥样硬化, 辅助性T细胞17, 调节性T细胞, 白细胞介素17, 细胞毒性T淋巴细胞相关抗原-4, 牙周干预治疗

Abstract:

Periodontitis is a chronic infectious disease in which periodontal tissue loss is caused by dental plaque biofilm. Atherosclerosis is a chronic inflammatory disease that occurs in the walls of arteries and is characterized by lipid accumulation. Recently, many studies have suggested that there is a certain relationship between periodontitis and atherosclerosis. From an epidemiological perspective, a previous literature review indicated that patients with periodontitis have a higher incidence of atherosclerosis. IL-17 secreted by Th17 cells may aggravate the progression of the two diseases by elevating the levels of matrix metalloproteinases, which may damage the connective tissue. Treg cells reduce the activation of T cells and limit the development of inflammation by secreting anti-inflammatory factors and expressing coinhibitory molecules. Periodontal intervention may contribute to the treatment of atherosclerosis by reducing inflammatory markers in atherosclerosis. Many studies have shown that periodontitis and atherosclerosis may interact with each other, but further studies are needed to explore the concrete mechanism of the interaction between periodontitis and atherosclerosis.

Key words: periodontitis, atherosclerosis, T helper cell 17, regulatory T cell, interleukin 17, cytotoxic T-lymphocyte-associated protein-4, periodontal intervention treatment

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