口腔疾病防治 ›› 2022, Vol. 30 ›› Issue (8): 600-603.DOI: 10.12016/j.issn.2096-1456.2022.08.011

• 综述 • 上一篇    下一篇

慢性牙周炎患牙拔牙窝内反应性软组织应用研究进展

赵夕文(), 欧其雅芝, 满毅()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院种植科,四川 成都 (610041)
  • 收稿日期:2021-06-30 修回日期:2022-03-15 出版日期:2022-08-20 发布日期:2022-05-09
  • 通讯作者: 满毅
  • 作者简介:赵夕文,硕士研究生,Email: 976632873@qq.com
  • 基金资助:
    国家自然科学基金项目(81970965);四川大学华西口腔医院探索与研发项目(LCYJ2019-19)

Application of reactive soft tissue preservation in extraction sockets of periodontitis: recent progress and perspectives

ZHAO Xiwen(), OUQI Yazhi, MAN Yi()   

  1. Department of Oral Implantology & National Clinical Research Center for Oral Diseases & State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-06-30 Revised:2022-03-15 Online:2022-08-20 Published:2022-05-09
  • Contact: MAN Yi
  • Supported by:
    National Natural Science Foundation of China(81970965);Research and Develop Program, West China Hospital of Stomatology Sichuan University(LCYJ2019-19)

摘要:

慢性牙周炎的发病率高,是失牙的主要原因之一。在长期慢性炎症环境中,受复杂的免疫调控而形成的反应性软组织,在患牙拔除后常残留于拔牙窝内,以往主张将其彻底清除。近期有研究者对反应性软组织的临床实践做出了新尝试,提示保留反应性软组织对于口腔中软组织和硬组织的再生有益。此外,研究表明间充质干细胞可成功地从反应性软组织中分离,说明反应性软组织在组织再生治疗中具有巨大潜力。尽管反应性软组织有望在口腔软、硬组织再生方面发挥积极作用,但目前尚无文献说明反应性软组织中的间充质干细胞的数量、成分、保留的具体标准。未来研究应着重于探究如何利用反应性软组织中间充质干细胞进行组织再生治疗,并形成保留反应性软组织的具体标准。

关键词: 拔牙窝, 反应性软组织, 肉芽组织, 慢性牙周炎, 间充质干细胞, 高通量测序技术, 免疫调节, 炎性微环境, 组织再生, 即刻种植

Abstract:

Chronic periodontitis is a prevalent disease; if left untreated, it is a main indication for tooth extraction and can lead to tooth loss. The reactive soft tissue, formed as a result of the immune response to chronic inflammation, is left in the compromised socket. The major concern is how to deal with the residual reactive soft tissue. Conservative thought states that the reactive soft tissue should be completely debrided. In addition, novel practices concerning the reactive soft tissue were proposed in recent trials, which demonstrated that there might be merits for soft and hard tissue regeneration with preservation of the reactive soft tissue. Studies have shown that mesenchymal stem cells exist in inflammatory reactive soft tissue, stressing their potential in tissue regeneration. Although the therapeutic value is highly promising, the specific components of the reactive soft tissue and the standard on whether it should be preserved need further investigation.

Key words: extraction sockets, reactive soft tissue, granulation tissue, chronic periodontitis, mesenchymal stem cells, high-throughput sequencing technology, immune regulation, inflammatory microenvironment, tissue regeneration, immediate implantation

中图分类号: