口腔幽门螺杆菌感染与胃幽门螺杆菌感染以及牙周炎的相关性研究

doi:10.12016/j.issn.2096-1456.2016.02.005

口腔疾病防治 ›› 2016, Vol. 24 ›› Issue (2): 91-93.DOI: 10.12016/j.issn.2096-1456.2016.02.005

所属专题： 111

口腔幽门螺杆菌感染与胃幽门螺杆菌感染以及牙周炎的相关性研究

朱晓茹¹(),邓天政¹,逄键梁¹,徐姗²,刘冰¹

1.空军总医院口腔科,北京(100142)
2.空军总医院干部病房四区

收稿日期:2015-07-24 修回日期:2015-08-19 出版日期:2016-02-20 发布日期:2016-02-20
通讯作者: 朱晓茹
基金资助:
军队保健专项课题(15BJZ20)

The correlation of Helicobacter pylori infection in the oral cavity and in the stomach and periodontitis

Xiao-ru ZHU¹(),Tian-zheng DENG¹,Jian-liang PANG¹,Shan XU²,Bing LIU¹

¹Department of Stomatology, Air Force General Hospital, PLA, Beijing 100142, China

Received:2015-07-24 Revised:2015-08-19 Online:2016-02-20 Published:2016-02-20
Contact: Xiao-ru ZHU

摘要/Abstract

摘要：

目的探讨口腔内幽门螺杆菌(Helicobacter pylori,Hp)感染与胃内Hp感染以及与牙周炎的关系。方法通过 ¹³C尿素呼气试验检测法和幽门螺杆菌唾液测试法对120例有消化道症状的患者进行胃内和口腔内Hp的检测,并对患者进行牙周检查,分析口腔Hp感染与胃Hp感染的关系以及与牙周炎的关系。结果 120例有消化道症状的患者中,胃Hp阳性患者口腔Hp的阳性率为87.7%,胃Hp阴性患者口腔Hp的阳性率为42.6%,两者差异有统计学意义(χ ²=27.715,P<0.001);牙周正常者、轻度牙周炎患者、中度牙周炎患者和重度牙周炎患者中口腔Hp感染的阳性率分别为45.5%、55.3%、81.5%和82.4%,差异有统计学意义(χ ²=11.711,P<0.01)。结论口腔Hp感染与胃Hp感染密切相关,可能是胃Hp感染的来源;口腔Hp感染也与牙周炎的严重程度相关。

关键词: 幽门螺杆菌, 口腔, 胃, 牙周炎, ¹³C尿素呼气试验

Abstract:

Objective To investigate the correlation of Helicobacter pylori infection in the oral cavity and stomach, and correlation of Helicobacter pylori infection in the oral cavity and periodontitis. Methods 120 patients with chronic gastric diseases received ¹³C-urea breath test, Hp saliva test and periodontal examination. The correlation of Helicobacter pylori infection in the oral cavity and stomach, and correlation of Helicobacter pylori infection in the oral cavity and periodontitis were analyzed. Results The experiments showed that the positive rate of Hp in the oral cavity was 87.7% in stomach-Hp-positive patients, while the positive rate of Hp in the oral cavity was only 42.6% in stomach-Hp-negative patients, which was significantly lower (P<0.001). The positive rate of Hp in the oral cavity in patients with normal periodontium, mild periodontitis, moderate periodontitis and severe periodontitis were 45.5%, 55.3%, 81.5% and 82.4% separately, and the difference was statistically significant (P<0.01). Conclusion Hp infection in the oral cavity is closely related to its infection in the stomach, and is also related to the severity of periodontitis.

Key words: Helicobacter pylori, Oral cavity, Stomach, Periodontitis, ¹³C-urea breath test

中图分类号:

R781.4

朱晓茹,邓天政,逄键梁,徐姗,刘冰. 口腔幽门螺杆菌感染与胃幽门螺杆菌感染以及牙周炎的相关性研究[J]. 口腔疾病防治, 2016, 24(2): 91-93.

Xiao-ru ZHU,Tian-zheng DENG,Jian-liang PANG,Shan XU,Bing LIU. The correlation of Helicobacter pylori infection in the oral cavity and in the stomach and periodontitis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(2): 91-93.

图/表 2

参考文献 16

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¹³C-UBT检测	HPS检测		合计
¹³C-UBT检测	阳性	阴性	合计
阳性	64	9	73
阴性	20	27	47
合计	84	36	120

¹³C-UBT检测	HPS检测		合计
¹³C-UBT检测	阳性	阴性	合计
阳性	64	9	73
阴性	20	27	47
合计	84	36	120

口腔幽门螺杆菌感染与胃幽门螺杆菌感染以及牙周炎的相关性研究

The correlation of Helicobacter pylori infection in the oral cavity and in the stomach and periodontitis

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Metrics

组别	HPS检测		合计	阳性率
组别	阳性	阴性	合计	阳性率
牙周正常组	5	6	11	45.5%
轻度牙周炎组	21	17	38	55.3%
中度牙周炎组	44	10	54	81.5%
重度牙周炎组	14	3	17	82.4%
合计	84	36	120	70.0%

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