口腔疾病防治 ›› 2016, Vol. 24 ›› Issue (2): 101-104.DOI: 10.12016/j.issn.2096-1456.2016.02.008

所属专题: 111

• 临床研究 • 上一篇    下一篇

纳米碳混悬液示踪早期舌鳞癌前哨淋巴结的临床研究

钟江龙,范松,陈伟良(),李群星,王友元,张大明   

  1. 中山大学孙逸仙纪念医院口腔颌面外科,广东 广州(510120
  • 收稿日期:2015-09-21 修回日期:2015-11-10 出版日期:2016-02-20 发布日期:2016-02-20
  • 通讯作者: 陈伟良
  • 作者简介:钟江龙,医师,硕士, Email:zhonhj19@126.com
  • 基金资助:
    国家自然科学基金(81172563/H1625)

Clinical study on sentinel lymph node tracked by carbon nanoparticles on early tongue squamous cell carcinoma

Jiang-long ZHONG,Song FAN,Wei-liang CHEN(),Qun-xing LI,You-yuan WANG,Da-ming ZHANG   

  1. Department ofOral and Maxillofacial Surgery, Sun Yat-sen Memorial of Sun Yat-san University, Guangzhou 510120, China
  • Received:2015-09-21 Revised:2015-11-10 Online:2016-02-20 Published:2016-02-20
  • Contact: Wei-liang CHEN

摘要:

目的 评估纳米碳混悬液示踪cT1-2N0舌鳞癌前哨淋巴结的效果,进一步探究其在口腔癌前哨淋巴结活检中的应用价值。方法 58例cT1-2N0的舌鳞癌患者被纳入本次前瞻性研究。其中试验组30例患者术前于癌周注射纳米碳混悬液,对照组28例患者术前癌周注射亚甲蓝。所有受试者均接受选择性颈淋巴清扫术。结果 试验组较对照组术野清晰,染色淋巴结与周围组织界限清楚。试验组中,纳米碳混悬液对前哨淋巴结的检出率、敏感度、准确率和假阴性率分别为96.7%(29/30)、87.5%(7/8)、93.3%(28/30)和12.5%(1/8);对照组中亚甲蓝对前哨淋巴结的检出率、敏感度、准确率和假阴性率分别为92.8%(26/28)、66.7%(4/6)、85.7%(24/28)和33.3%(2/6),2组差异均无统计学意义(P>0.05)。结论 纳米碳混悬液有助于前哨淋巴结的检出,注射纳米碳混悬液可作为舌鳞癌前哨淋巴结活检的重要辅助手段。

关键词: 舌癌, 癌, 鳞状细胞, 前哨淋巴结, 示踪, 纳米碳混悬液

Abstract:

Objective To investigate the efficacy of carbon-nanoparticles suspension in detecting sentinel lymph nodes in cT1-2N0 oral tongue carcinoma and explore the application value of carbon-nanoparticles suspension in sentinel lymph node biopsy. Methods Fifty-eight patients with cT1-2N0 oral tongue carcinoma were enrolled in this prospective trial. Thirty patients received carbon nanoparticle injection around the tumor pre-operatively (experimental group), and the remaining 28 were injected with methylene blue dye (control group). All patients underwent elective neck dissection and routine pathological examination was performed in all resected specimens. Results The experimental group had a clear surgical field compared with the control group, and there is clear boundary between the staining lymph nodes and surrounding tissue. In the experimental group, the detection rate, sensitivity, accuracy rate, and false negative rate of the carbon-nanoparticles suspension were 96.7% (29/30), 87.5% (7/8), 93.3% (28/30), and 12.5% (1/8), respectively compared with 92.8% (26/28), 66.7% (4/6), 85.7% (24/28), and 33.3% (2/6), respectively, of the control group. There is no significant difference in both groups (P>0.05). Conclusion The application of carbon-nanoparticles suspension facilitate sentinel lymph node detection and histological evaluation and therefore, could be an important adjunct to sentinel lymph node biopsy in oral tongue squamous cell carcinoma.

Key words: Tongue carcinoma, Squamous cell, carcinoma, Sentinel lymph nodes, Track, Carbon-nanoparticles suspension

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