口腔疾病防治 ›› 2018, Vol. 26 ›› Issue (6): 391-395.DOI: 10.12016/j.issn.2096-1456.2018.06.011

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低龄儿童龋致龋微生物相关生物标志物的研究进展

<a href="http://www.kqjbfz.com/CN/article/advancedSearchResult.do?searchSQL=((([Author]) AND 1[Journal]) AND year[Order])" target="_blank"></a><sup>1,</sup><sup>2</sup>(<a href="mailto:fove@foxmail.com"><img src="/images/email.png" border="0" /></a>), <a href="http://www.kqjbfz.com/CN/article/advancedSearchResult.do?searchSQL=((([Author]) AND 1[Journal]) AND year[Order])" target="_blank"></a><sup>1,</sup><sup>2</sup>, <a href="http://www.kqjbfz.com/CN/article/advancedSearchResult.do?searchSQL=((([Author]) AND 1[Journal]) AND year[Order])" target="_blank"></a><sup>1,</sup><sup>2</sup>, <a href="http://www.kqjbfz.com/CN/article/advancedSearchResult.do?searchSQL=((([Author]) AND 1[Journal]) AND year[Order])" target="_blank"></a><sup>1,</sup><sup>2</sup>(<a href="mailto:dentistzoujing@163.com"><img src="/images/email.png" border="0" /></a>)   

  1. 1. 口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川 成都(610041)
    2. 四川大学华西口腔医院儿童口腔科,四川 成都(610041)
  • 收稿日期:2017-12-03 修回日期:2018-03-22 出版日期:2018-06-20 发布日期:2018-08-30
  • 作者简介:

    【作者简介】 韩轩,住院医师,硕士,Email: fove@foxmail.com

  • 基金资助:
    国家自然科学基金项目(81470035);国家自然科学基金项目(81400502)

Research progress of microbial biomarkers of early childhood caries

Xuan HAN1,2(), Yuanyuan HUO1,2, Qiong ZHANG1,2, Yuqing LI1, Jing ZOU1,2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China
    2. Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-12-03 Revised:2018-03-22 Online:2018-06-20 Published:2018-08-30

摘要:

健康儿童口腔存在动态平衡的微生物群落环境,当这种平衡遭到破坏,部分微生物将转变为致龋微生物并引发低龄儿童龋(Early Childhood Caries, ECC)。致龋微生物在ECC发病过程中发生的改变可作为评估儿童患龋风险及预测ECC发展速度的生物标志物,对ECC的诊疗意义非凡。就目前研究较多的数种微生物而言,变异链球菌和与其密切相关的白假丝酵母菌、双歧杆菌属、血链球菌的相关指标有可能作为生物标志物联合判断儿童龋易感性。乳杆菌属的检出率和检出水平可能为判断ECC发展速度提供参考。

关键词: 低龄儿童龋, 微生物, 生物标志物, 学龄前儿童, 龋病

Abstract:

The microorganisms in a healthy child’s oral environment survive in certain proportions and form a stable dynamic balance with the host. If this balance is disrupted, some of the microorganisms become cariogenic microbes and cause early childhood caries (ECC). The changes of cariogenic microbes in this process could be used as biomarkers to assess the caries risk of children and forecast the development of ECC. The relative indices of Streptococcus mutans and the closely related Candida albicans, Bifidobacterium and Streptococci sanguinis may be used as biomarkers to diagnose the susceptibility of children to caries. The detection rate and detection level of Lactobacillus may provide a reference for judging the rate of ECC development.

Key words: Early childhood caries, Microorganism, Biomarker, Preschool children, Dental caries

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