口腔疾病防治 ›› 2019, Vol. 27 ›› Issue (5): 318-320.DOI: 10.12016/j.issn.2096-1456.2019.05.009

• 防治实践 • 上一篇    下一篇

青少年口腔疣状黄瘤病例报道及文献复习

林琳,段宁,王翔,蒋红柳,王文梅()   

  1. 南京大学医学院附属口腔医院,南京市口腔医院口腔黏膜病科,江苏 南京(210008)
    南京大学医学院附属口腔医院,南京市口腔医院口腔黏膜病科,江苏 南京(210008
    南京大学医学院附属口腔医院,南京市口腔医院口腔黏膜病科,江苏 南京(210008)
  • 收稿日期:2018-07-17 修回日期:2018-09-01 出版日期:2019-05-20 发布日期:2019-05-20
  • 通讯作者: 王文梅
  • 作者简介:林琳,医师,硕士,Email:lin.09.11@163.com
  • 基金资助:
    国家自然科学基金项目(81570978);江苏省临床医学科技专项(BL2014018)

Oral verrucous xanthoma in adolescents: a case report and literature review

LIN Lin,DUAN Ning,WANG Xiang,JIANG Hongliu,WANG Wenmei()   

  1. Department of Oral Mucosa Disease, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China
  • Received:2018-07-17 Revised:2018-09-01 Online:2019-05-20 Published:2019-05-20
  • Contact: Wenmei WANG

摘要:

目的 探讨青少年疣状黄瘤(verruciform xanthoma,VX)的病因、临床表现、诊断及治疗方法,为临床诊疗提供参考。方法 对收治的1例青少年腭部肿物病例的临床资料进行分析,并回顾相关文献。结果 该例患者腭部肿物经组织病理学检查证实为疣状黄瘤,手术切除,预后良好。文献回顾分析显示,疣状黄瘤是一种罕见的病因不明的良性黏膜皮肤病变,发生率约0.025%~0.094%,好发于中年人群,无明显性别差异。临床表现与鳞状乳头状瘤、寻常疣、纤维瘤、疣状癌和鳞状细胞癌等多种疾病相似,不易鉴别,需要依靠组织病理学诊断。疣状黄瘤局部切除即可治愈,不易复发。结论 在临床中遇到青少年的黏膜孤立性肿物,需进行病理检查,避免过度治疗。

关键词: 疣状黄瘤, 青少年, 疣状癌, 口腔鳞状细胞癌, 人乳头状瘤病毒, 巨噬细胞, 淋巴细胞

Abstract:

Objective To explore the etiology, clinical manifestations, diagnosis and treatment of verruciform xanthoma (VX) in adolescents to provide a reference for clinical diagnosis and treatment.Methods The clinical data of a case of a palatal mass in a juvenile were analyzed, and the related literature was reviewed.Results The palatal mass was proven to be VX by histopathological examination. Surgical resection was performed, and the prognosis was good. A review of the literature shows that VX is a rare benign mucosal skin lesion of an unknown etiology, with an incidence of approximately 0.025%-0.094%; VX is mostly found in middle-aged people, with no significant difference by sex. The clinical manifestations are similar to those of a variety of diseases, such as squamous papilloma, verruca vulgaris, fibroma, warty carcinoma and squamous cell carcinoma, which are not easy to distinguish and require histopathological diagnosis. The treatment of choice is surgical excision, with a low recurrence rate.Conclusion In the clinical experience of solitary mucosal masses in juveniles, it is necessary to send biopsy for pathological examination and avoid overtreatment.

Key words: Verrucous xanthoma, Adolescents, Verrucous carcinoma, Oral squamous cell carcinoma, Human papillomavirus, Macrophage, Lymphocyte

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