口腔疾病防治 ›› 2020, Vol. 28 ›› Issue (8): 477-486.DOI: 10.12016/j.issn.2096-1456.2020.08.001

• 专家论坛 • 上一篇    下一篇

上颌窦底黏膜在上颌窦底提升术后窦底空间成骨中的作用

陈松龄(),朱双喜   

  1. 中山大学附属第一医院口腔科,广东 广州(510080)
  • 收稿日期:2019-08-11 修回日期:2020-02-14 出版日期:2020-08-20 发布日期:2020-07-15
  • 通讯作者: 陈松龄
  • 作者简介:陈松龄,主任医师,教授,博士生导师,中山大学第一附属医院口腔科学科带头人,首席专家。兼任中华口腔医学会牙及牙槽外科专业委员会副主任委员,中华口腔医学会口腔颌面外科专业委员会委员,中国香港地区口腔种植学会副会长,国际口腔种植医师学会(The International Congress of Oral Implantologists,ICOI)中国总会副会长,中国康复医学会修复重建外科专业委员会颅颌面外科学组委员,广东省口腔医学会理事,广东省临床医学学会牙种植学专业委员会主任委员,广东省口腔医学会口腔种植学专业委员会副主任委员、口腔颌面外科专业委员会常务委员,《口腔疾病防治》、《中华口腔医学研究杂志(电子版)》等期刊编委。主持承担国家自然科学基金、省级科研基金课题12项。获得广东省科学技术奖1项。发表学术论文120篇,其中以第一或通信作者发表SCI论文23篇。在国际上提出上颌窦黏膜干细胞成骨概念,获得2017年国际口腔种植医师学会最高年度奖(Ralph V. Mckinney,Jr. Award in basic and clinical research for 2017)
  • 基金资助:
    国家自然科学基金项目(81371111);国家自然科学基金项目(81900973);广东省自然科学基金项目(2014A030313059)

The role of the membrane of the maxillary sinus in space osteogenesis under the sinus floor after elevation of the sinus floor

CHEN Songling(),ZHU Shuangxi   

  1. Department of Stomatology, The First Affiliated Hospital, SunYat-sen University, Guangzhou 510080, China
  • Received:2019-08-11 Revised:2020-02-14 Online:2020-08-20 Published:2020-07-15
  • Contact: Songling CHEN

摘要:

上颌窦底提升的技术不断发展,上颌窦底提升后的成骨机制一直是学者关注的问题。上颌窦黏膜是上颌窦底提升后窦底空间成骨过程中不可或缺的生理结构,近年来有关上颌窦底黏膜在窦底空间成骨中的作用是一个研究热点。研究表明,在上颌窦底提升术后窦底空间成骨过程中,上颌窦底黏膜发挥天然的生物屏障膜的作用,同时,其本身具有成骨能力。研究还发现上颌窦底黏膜来源的上颌窦黏膜干细胞(maxillary sinus membrane stem cells, MSMSCs)具有间充质干细胞特性,可分化为成骨细胞,参与上颌窦底提升术后的窦底空间成骨;微小RNAs、长链非编码RNAs和环状RNAs等小分子RNA可调控MSMSCs成骨分化,这可能是促进窦底空间成骨重要的生物靶点。本文将从上颌窦底黏膜与上颌窦底提升成骨的关系、上颌窦底黏膜的屏障和成骨功能、参与窦底空间成骨的成骨细胞来源、上颌窦黏膜干细胞成骨分化的分子调控机制作一阐述。

关键词: 牙种植, 上颌窦底提升术, 上颌窦底黏膜, 上颌窦黏膜干细胞, 微小RNAs, 长链非编码RNAs, 环状RNAs, 成骨分化

Abstract:

With the continuous development of maxillary sinus floor elevation technology, the osteogenesis mechanism of maxillary sinus floor elevation has always been a concern of scholars. The membrane of the maxillary sinus is an indispensable physiological structure in the process of space osteogenesis under the sinus floor after elevation of the sinus floor. In recent years, the role of the maxillary sinus floor mucosa in sinus floor space osteogenesis has been a research hotspot. Recent studies have found that the maxillary sinus floor membrane plays a role as a natural biological barrier membrane in the process of sinus floor space osteogenesis after maxillary sinus floor elevation; in addition, it has the ability to undergo osteogenesis. It has also been found that maxillary sinus membrane stem cells (MSMSCs) derived from the maxillary sinus floor membrane have characteristics of mesenchymal stem cells, which can differentiate into osteoblasts and participate in sinus floor space osteogenesis after maxillary sinus floor elevation. New studies have also found that small RNAs such as microRNAs, long noncoding RNAs and circular RNAs can regulate the osteogenic differentiation of MSMSCs, which may be important biological targets for promoting osteogenesis in the sinus floor space. In this paper, the relationship between the maxillary sinus floor mucosa and bone formation after maxillary sinus floor elevation, the barrier and osteogenic function of the maxillary sinus floor mucosa, the sources of osteoblasts involved in osteogenesis of the sinus floor space, and the molecular regulatory mechanisms of stem cells derived from maxillary sinus mucosa will be elucidated step by step.

Key words: dental implantation, maxillary sinus floor elevation, maxillary sinus floor membrane, maxillary sinus membrane stem cells, microRNAs, long non-coding RNAs, circular RNAs, osteogenic differentiation

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