口腔疾病防治 ›› 2020, Vol. 28 ›› Issue (8): 506-509.DOI: 10.12016/j.issn.2096-1456.2020.08.005

• 临床研究 • 上一篇    下一篇

重度低龄儿童龋患者铁锌铜及维生素D的血清水平

朱少军1,热娜·买买提2,张蓓1,王智亨1,葛金莲3,刘奕杉1()   

  1. 1.新疆医科大学第一附属医院(附属口腔医院)儿童口腔科-口腔预防科,新疆维吾尔自治区 乌鲁木齐(830054)
    2.新疆医科大学健康管理中心儿童保健科,新疆维吾尔自治区 乌鲁木齐(830054)
    3.新疆医科大学第一附属医院检验中心,新疆维吾尔自治区 乌鲁木齐(830054
  • 收稿日期:2019-11-11 修回日期:2020-02-11 出版日期:2020-08-20 发布日期:2020-07-15
  • 通讯作者: 刘奕杉
  • 作者简介:朱少军,医师,硕士研究生在读,Email: 18844928677@163.com
  • 基金资助:
    国家自然科学基金项目(81560178)

Serum levels of iron, zinc, copper and vitamin D in severe early childhood caries

ZHU Shaojun1,RENA· Maimaiti2,ZHANG Bei1,WANG Zhiheng1,GE Jinlian3,LIU Yishan1()   

  1. 1. Department of Pediatric and Preventive Dentistry, The First Affiliated Hospital of Xinjiang Medical University(Affiliated Stomatological Hospital), Urumqi 830054, China
    2. The Child Health Department of the Xinjiang Medical University Health Management Center, Urumqi 830054, China
    3. Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
  • Received:2019-11-11 Revised:2020-02-11 Online:2020-08-20 Published:2020-07-15
  • Contact: Yishan LIU

摘要:

目的 调查及分析重度低龄儿童龋(severe early childhood caries,S-ECC)患者中铁、锌、铜微量元素及维生素D的血清水平,为S-ECC儿童的一级预防及诊疗提供参考。方法 选取2018年6月~2019年6月就诊于新疆医科大学健康管理中心儿童保健科儿童(3~5岁)184例,分为无龋组(caries free,CF)(n=89)和S-ECC组(n=95),抽血检测其铁、锌、铜3项微量元素及25羟维生素D的含量。 结果 CF组与S-ECC组铁的血清含量为(8.36 ± 0.42)mmol/L、(8.13 ± 0.44)mmol/L,差异有统计学意义(t=3.50,P < 0.001);锌的血清含量为(83.18 ± 7.28)μmol/L、(79.23 ± 6.38)μmol/L,差异有统计学意义(t=3.92,P < 0.001);25羟维生素D的血清含量为(86.72 ± 15.83)nmol/L、(77.75 ± 11.38)nmol/L,差异有统计学意义(t=4.42,P < 0.001);铜的血清含量为(20.18 ± 4.84)μmol/L、(19.49 ± 4.62)μmol/L,但差异无统计学意义(t=0.97,P=0.33)。结论 S-ECC患者血清中铁、锌及维生素D的含量较低,提示在S-ECC 的防治过程中应重视铁、锌及维生素D的补充。

关键词: 重度低龄儿童龋, 乳牙龋齿, 微量元素, 铁, 锌, 铜, 维生素D, 一级预防

Abstract:

Objective The serum levels of iron, zinc, copper and vitamin D in severe early childhood caries (S-ECC) patients were investigated and analyzed to provide reference for primary prevention and diagnosis of S-ECC children. Methods A total of 184 children were enrolled in the Children Health Department of Xinjiang Medical University Health Management Center from June 2018 to June 2019. They were divided into the caries-free (CF) group (n=89) and S-ECC group (n=95). The contents of iron, zinc, copper and vitamin D were detected. Results The serum iron content of the CF group and S-ECC group was (8.36 ± 0.42) mmol/L and (8.13 ± 0.44) mmol/L, respectively, and the difference was statistically significant (t=3.50, P < 0.001); the serum content of zinc was (83.18 ± 7.28) μmol/L and (79.23 ± 6.38) μmol/L, respectively, and the difference was statistically significant (t=3.92, P < 0.001); the serum content of 25-hydroxyvitamin D was (86.72 ± 15.83) nmol/L and (77.75 ± 11.38) nmol/L, respectively, and the difference was statistically significant (t=4.42, P < 0.001). The serum copper content of CF group and S-ECC group was (20.18 ± 4.84) μmol/L and (19.49 ± 4.62) μmol/L, but the difference was not statistically significant (t=0.97, P=0.33). Conclusion The contents of iron, zinc and vitamin D in the serum of S-ECC patients are low, suggesting that iron, zinc and vitamin D supplementation should be emphasized in the prevention and treatment of S-ECC.

Key words: severe early childhood caries, deciduous tooth caries, trace elements, iron, zinc, copper, vitamin D, primary prevention

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