口腔疾病防治 ›› 2020, Vol. 28 ›› Issue (8): 535-539.DOI: 10.12016/j.issn.2096-1456.2020.08.011

• 综述 • 上一篇    下一篇

声动力疗法在口腔医学领域的研究进展

许斌,毕良佳()   

  1. 哈尔滨医科大学附属第四医院口腔科,黑龙江 哈尔滨(150001)
  • 收稿日期:2019-04-07 修回日期:2020-03-13 出版日期:2020-08-20 发布日期:2020-07-15
  • 通讯作者: 毕良佳
  • 作者简介:许斌,医师,硕士研究生在读,Email: 603309655@qq.com
  • 基金资助:
    国家自然科学基金项目(81670994)

Research progress of sonodynamic therapy in the field of stomatology

XU Bin,BI Liangjia()   

  1. Department of Stomatology, the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001, China
  • Received:2019-04-07 Revised:2020-03-13 Online:2020-08-20 Published:2020-07-15
  • Contact: Liangjia BI

摘要:

声动力疗法(sonodynamic therapy,SDT)是超声联合声敏剂产生生物学效应的前沿方法。近些年来逐渐被口腔领域的专家学者所关注,开展了一系列的研究。本文将从SDT的治疗机制、在口腔领域的研究与应用以及在治疗口腔疾病方面的现状来介绍SDT在口腔医学领域的研究进展。目前认为单线态氧理论、空化效应和诱导细胞凋亡等为其主要治疗机制。SDT在口腔疾病防治方面的研究主要集中在口腔肿瘤(尤其是鳞状细胞癌和骨肉瘤)及感染性疾病(如牙周炎、颌面部感染、口腔黏膜病等)两方面。尽管现在的研究仍处于探索阶段,但随着研究者对声敏剂、纳米技术等的不断研究与探索,SDT将会为今后的口腔疾病临床防治工作提供重要帮助。

关键词: 声动力疗法, 超声, 声敏剂, 单线态氧理论, 空化效应, 细胞凋亡, 牙周炎, 口腔肿瘤, 口腔黏膜病, 纳米粒子

Abstract:

Sonodynamic therapy (SDT) is a cutting-edge method for the biological effects of ultrasound combined with sound-sensitive agents. In recent years, SDT has been a concern of experts and scholars in the oral field, and a series of experimental studies has been carried out. We will introduce the progress of SDT in the field of stomatology from three aspects: the therapeutic mechanism of SDT, the application of SDT in the oral field, and the current situation and future of SDT in the treatment of oral diseases. It is currently believed that singlet oxygen theory, cavitation effects, and induction of apoptosis are the main therapeutic mechanisms. The research of SDT on oral disease prevention mainly focuses on oral tumors (especially squamous cell carcinoma and osteosarcoma) and infectious diseases (such as periodontitis, maxillofacial infection, and oral mucosal disease). Although the current research is still in the experimental stage, with the continuous exploration of sonosensitizers and nanotechnology, SDT will provide great help for the clinical prevention and treatment of oral diseases in the future.

Key words: sonodynamic therapy, ultrasound, sonosensitizer, singlet oxygen theory, cavitation effects, apoptosis, periodontitis, oral tumor, oral mucosal disease, nanoparticles

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