口腔疾病防治 ›› 2021, Vol. 29 ›› Issue (1): 57-60.doi: 10.12016/j.issn.2096-1456.2021.01.009

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基于颌骨和股骨差异的动物实验中种植体骨结合影响因素

唐渝菲1(),周安琪1,于晖2,刘珍珍3,张歆缘2,王斌2,张恺文1,向琳2()   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院,四川 成都(610041)
    2.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院种植科, 四川 成都(610041)
    3.四川大学华西口腔医院唇腭裂外科,四川 成都(610041)
  • 收稿日期:2019-11-13 修回日期:2020-04-16 出版日期:2021-01-20 发布日期:2020-11-18
  • 通讯作者: 向琳 E-mail:tangyufei420@163.com;dentistxiang@126.com
  • 作者简介:唐渝菲,本科,Email: tangyufei420@163.com
  • 基金资助:
    国家自然科学基金(81701007);四川大学华西口腔医院人才队伍建设科研经费(RCDWJS2020-6);中央高校基本科研业务费专项资金(2018SCUH0006);四川大学华西口腔医院基础与应用基础研究项目(RD-02-201902)

Differences in implant osseointegration in the jaw and femur in animal experiments

TANG Yufei1(),ZHOU Anqi1,YU Hui2,LIU Zhenzhen3,ZHANG Xinyuan2,WANG Bin2,ZHANG Kaiwen1,XIANG Lin2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Deptartment of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    3. Deptartment of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-11-13 Revised:2020-04-16 Online:2021-01-20 Published:2020-11-18
  • Contact: Lin XIANG E-mail:tangyufei420@163.com;dentistxiang@126.com
  • Supported by:
    National Natural Science Foundation of China(81701007);Research Funding for Talents Developing, West China Hospital of Stomatology, Sichuan University(RCDWJS2020-6);Fundamental Research Funds for the Central Universities(2018SCUH0006);Basic and Applied Basic Research Project of West China Hospital of Stomatology, Sichuan University(RD-02-201902)

摘要:

颌骨和股骨是基础研究中常用的构建骨缺损或植入种植体的部位。越来越多的研究指出,颌骨和股骨二者在胚胎发育及生长、组织形态学结构以及骨代谢等方面存在较大差异。文献复习结果表明与股骨相比,颌骨的骨膜内成骨方式可能具有更优的成骨能力,同时其内的干细胞增殖能力更强,成骨分化能力更好;但颌骨组织结构的规律性欠佳,成骨细胞成骨矿化能力稍弱,免疫细胞对细胞因子更敏感,这些可能是导致动物实验中颌骨与股骨种植体骨结合存在差异的原因,但其具体机制尚未阐明。

关键词: 牙列缺损; 口腔种植义齿; 骨结合; 骨代谢; 颌骨; 股骨; 胚胎发育; 组织形态学

Abstract:

The jaw and femur are commonly used sites in basic research for modeling bone defects or inserting implants. An increasing number of studies have identified that the jaw and femur indeed show great differences in embryonic development and growth, histomorphology and bone metabolism. A literature review showed that, compared with the femur, the main osteogenic pathway of the jaw may have better osteogenic ability, and its stem cells have better proliferation and osteogenic differentiation ability. However, the jaw structure is less regular, the osteogenic differentiation ability of its osteoblasts is mineralization slightly weak, and the immune cells of the jaw are more sensitive to cytokines. These may be the reasons why the osseointegration of the jaw implant is different from that of the femur in animal experiments, but its specific mechanism has not been clarified.

Key words: dentition defect; oral implant denture; osseointegration; bone metabolism; jaw bone; thigh bone; embryonic development; histomorphology

中图分类号: 

  • R78