口腔疾病防治 ›› 2021, Vol. 29 ›› Issue (2): 73-80.doi: 10.12016/j.issn.2096-1456.2021.02.001

• 专家论坛 • 上一篇    下一篇

口腔黏膜相关疾病免疫功能检测及意义

王安训()   

  1. 中山大学附属第一医院口腔颌面外科, 广东 广州(510080)
  • 收稿日期:2020-02-09 修回日期:2020-04-25 出版日期:2021-02-20 发布日期:2020-12-21
  • 通讯作者: 王安训 E-mail:wang_anxun@aliyun.com
  • 作者简介:王安训,1993 年毕业于中山医科大学口腔系,2001年毕业于中山医科大学肿瘤学专业,获博士学位,现任中山大学附属第一医院口腔颌面外科教授、博士生导师。兼任广东省口腔医学会口腔颌面外科专业委员会副主任委员、中国抗癌协会肿瘤微创外科治疗专业委员会副主任委员。主要从事口腔颌面部肿瘤的临床及基础研究,致力于提高早期预测口腔鳞癌的侵袭转移能力以及提高口腔鳞癌疗效的研究。目前已公开发表学术论文170 余篇,其中 SCI 论文 70 余篇。培养的多名研究生获得广东省优秀研究生和优秀研究生论文。负责多项国家级及省部级基金资助项目研究,包括教育部新世纪优秀人才支持计划、国家自然科学基金面上项目、广东省自然科学基金重点项目等。主编并编写了多本口腔医学专业著作,包括《口腔疾病》(副主编,科学技术文献出版社)、《牙槽外科手术视听教材》(主编,人民卫生电子音像出版社,“十五”国家重点音像出版规划)等。获教育部提名国家科技进步奖二等奖。
  • 基金资助:
    国家自然科学基金项目(NSFC81672659);广东省自然科学基金面上项目(2020A1515010291)

Detection and significance of immune function in oral mucosa-associated diseases

WANG Anxun()   

  1. Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
  • Received:2020-02-09 Revised:2020-04-25 Online:2021-02-20 Published:2020-12-21
  • Contact: Anxun WANG E-mail:wang_anxun@aliyun.com
  • Supported by:
    grants from National Nature Science Foundation of China(NSFC81672659);Guangdong Basic and Applied Basic Research Foundation(2020A1515010291)

摘要:

免疫功能的评估在多种疾病的诊断、治疗和预后评估中具有重要作用,目前常用的免疫功能检测包括细胞免疫、体液免疫以及炎症标志物等。本文首先讨论免疫功能及其检测在各种疾病诊断、鉴别诊断、治疗监测中的应用状况;然后结合文献资料和笔者课题组的研究,阐述免疫功能检测在3种常见口腔黏膜相关疾病诊断和治疗中的应用价值,包括复发性阿弗他溃疡(recurrent aphthous ulcer, RAU)、口腔扁平苔藓(oral lichen planus, OLP)以及口腔鳞状细胞癌(oral squamous cell carcinoma, OSCC)。笔者研究发现RAU患者呈现体液免疫功能异常和明显的炎症反应,OLP和OSCC患者呈现轻度的炎症反应和更为严重的细胞免疫功能和体液免疫功能的异常。由此可见免疫功能的联合检测对这些疾病的诊断和治疗具有一定的指导价值,但未来还必须开展大样本、多中心、多指标联合检测的研究,从而更加完善地阐明免疫功能异常在各种疾病发病中的作用及其机理,建立相应的诊断模型和预后预测模型,同时寻找更为有效的治疗手段。

关键词: 复发性阿弗他溃疡; 扁平苔藓; 口腔鳞状细胞癌; 口腔黏膜; 免疫功能; 淋巴细胞亚群; 细胞免疫; 体液免疫; 炎症; 生物标志物

Abstract:

The evaluation of immune function plays an important role in the diagnosis, treatment and prognosis of many diseases. To date, immune function detection includes cellular immunity, humoral immunity, and inflammatory markers. In this paper, the application of immune function detection in the diagnosis, differential diagnosis and treatment monitoring of various diseases was discussed; then, the application value of immune function detection in the diagnosis and treatment of three common oral mucosa-related diseases, including recurrent aphthous ulcer (RAU), oral lichen planus (OLP), and oral squamous cell carcinoma (OSCC), were reviewed combined with the literature and our research. Our research found that RAU patients present abnormal humoral immune function and obvious inflammatory reactions, whereas OLP and OSCC patients present mild inflammatory reactions and more serious abnormal cellular and humoral immune function, so the combined detection of immune function has a certain guiding value for the diagnosis and treatment of these diseases. Moreover, in the future, it is necessary to carry out a study on large sample, multicenter and multiindex joint detection to better clarify the role of immune dysfunction in the pathogenesis of various diseases and its mechanism, to establish the corresponding diagnostic model and prognostic prediction model, to find more effective treatment methods.

Key words: recurrent aphthous ulcer; lichen planus; oral squamous cell carcinoma; oral mucosa; immunity; lymphocyte subsets; cellular immunity; humoral immunity; inflammation; biomarkers

中图分类号: 

  • R781.5