口腔疾病防治 ›› 2021, Vol. 29 ›› Issue (2): 119-123.DOI: 10.12016/j.issn.2096-1456.2021.02.009

• 综述 • 上一篇    下一篇

白色念珠菌感染与口腔癌的关系

时洋洋[Author]) AND 1[Journal]) AND year[Order])" target="_blank">时洋洋(),周学东[Author]) AND 1[Journal]) AND year[Order])" target="_blank">周学东,程磊[Author]) AND 1[Journal]) AND year[Order])" target="_blank">程磊,任彪[Author]) AND 1[Journal]) AND year[Order])" target="_blank">任彪()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科,四川 成都(610041)
  • 收稿日期:2020-07-07 修回日期:2020-10-01 出版日期:2021-02-20 发布日期:2020-12-21
  • 通讯作者: 任彪
  • 作者简介:时洋洋,学士,Email: evenyshi@163.com
  • 基金资助:
    国家自然科学基金面上项目(81870778)

The relationship between Candida albicans infection and oral cancer

SHI Yangyang(),ZHOU Xuedong,CHENG Lei,REN Biao()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-07-07 Revised:2020-10-01 Online:2021-02-20 Published:2020-12-21
  • Contact: Biao REN
  • Supported by:
    grants from National Natural Science Foundation of China(81870778)

摘要:

口腔癌是头颈部最常见的癌症之一,严重影响患者生存质量和生活水平。白色念珠菌是口腔中最常见的机会性致病真菌,当宿主免疫功能低下时表现出致病性,容易引起念珠菌感染。近年来研究发现白色念珠菌感染与口腔癌关系密切,本文对口腔癌患者白色念珠菌感染的流行病学特点,以及白色念珠菌感染对口腔癌发生发展的影响及其机制研究进行综述。通过回顾相关文献发现:口腔癌患者白色念珠菌感染风险增加,白色念珠菌感染可能通过损伤口腔上皮、产生致癌物质、触发慢性炎症及辅助性T细胞17免疫反应等机制促进口腔癌的发生发展。然而目前这些机制的研究仍比较表浅,缺乏充足的直接证据,未来仍需进行大量研究,以期进一步明确白色念珠菌的促癌机制,为防治口腔癌提供新思路。

关键词: 白色念珠菌, 白色念珠菌, 口腔癌, 口腔癌, 口腔上皮损伤, 口腔上皮损伤, 亚硝胺, 亚硝胺, 乙醛, 乙醛, 慢性炎症, 慢性炎症, 辅助性T细胞17免疫反应, 辅助性T细胞17免疫反应

Abstract:

Oral cancer is one of the most common cancers that occur in the head and neck and can seriously affect the life span and living standard of oral cancer patients. Candida albicansC. albicans) is the most common opportunistic pathogenic fungus in the oral cavity, shows pathogenicity and easily causes Candida infection when the host′s immune function is low. Recent studies have shown that C. albicans infection is closely related to oral cancer. This paper reviews the epidemiology of C. albicans infection in oral cancer patients, the influence of C. albicans infection on the occurrence and development of oral cancer and research on its mechanism. Existing studies have shown an increased risk of C. albicans infection in oral cancer patients, while C. albicans infection may promote the occurrence and development of oral cancer through mechanisms such as damaging the oral epithelium; producing carcinogens, including nitrosamine and acetaldehyde; and inducing a chronic inflammatory response and T helper cell 17 immune response. However, these mechanisms are still relatively superficial and lack sufficient direct evidence. In the future, additional in-depth studies are still needed to further clarify the cancer-promoting mechanisms of C. albicans and provide new ideas for the prevention and treatment of oral cancer.

Key words: Candida albicans, Candida albicans, oral cancer, oral cancer, oral epithelial injury, oral epithelial injury, nitrosamines, nitrosamines, acetaldehyde, acetaldehyde, chronic inflammatory, chronic inflammatory, T helper cell 17 immune response, T helper cell 17 immune response

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