口腔疾病防治 ›› 2021, Vol. 29 ›› Issue (2): 135-139.DOI: 10.12016/j.issn.2096-1456.2021.02.012

• 综述 • 上一篇    下一篇

自体脂肪移植治疗腭咽闭合不全研究进展

路利丹1(),许辉2()   

  1. 1.新疆医科大学研究生院,新疆维吾尔自治区 乌鲁木齐(830011)
    2.新疆维吾尔自治区人民医院口腔颌面外科,新疆维吾尔自治区 乌鲁木齐(830011)
  • 收稿日期:2020-04-14 修回日期:2020-09-02 出版日期:2021-02-20 发布日期:2020-12-21
  • 通讯作者: 许辉
  • 作者简介:路利丹,硕士研究生在读,Email: 1170738720@qq.com
  • 基金资助:
    新疆维吾尔自治区自然科学基金资助项目(2015211C203)

Research progress on autologous fat transplantation in the treatment of velopharyngeal insufficiency

LU Lidan1(),XU Hui2()   

  1. 1. Postgraduate college of Xinjiang Medical University, Urumqi 830011, China
    2. Department of Oral and Maxillofacial Surgery, People′s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830011, China
  • Received:2020-04-14 Revised:2020-09-02 Online:2021-02-20 Published:2020-12-21
  • Contact: Hui XU
  • Supported by:
    grants from Natural Science Foundation of Xinjiang Uygur Autonomous Region(2015211C203)

摘要:

自体脂肪移植治疗腭咽闭合不全具有组织相容性好、局部创伤小、并发症少、操作可逆等优点,并能有效增大腭咽闭合面积。如临床效果欠佳,可随时采取其他手术方法替代。尽管自体脂肪移植治疗腭咽闭合不全有诸多优点,但在适应证的选择、供区部位、注射剂量、受区部位、随访评价、并发症及其防治等方面仍存在问题。目前研究表明,自体脂肪移植多应用于轻度及中度的腭咽闭合不全患者,但是随着脂肪获取和处理技术的不断提高,自体脂肪移植的适应证不断扩大,有学者提出可联合腭成形术或咽成形术治疗重度的腭咽闭合不全患者;但其也有并发症,主要包括脂肪吸收、阻塞性睡眠呼吸暂停综合征等。此外,关于自体脂肪移植在重度腭咽闭合不全患者中的应用以及如何提高自体脂肪移植的长期稳定性等方面尚需进一步研究。

关键词: 腭裂, 适应证, 自体脂肪移植, 腭咽闭合不全, 供区部位, 腭裂, 注射剂量, 适应证, 受区部位, 供区部位, 并发症, 注射剂量, 受区部位, 并发症

Abstract:

Autologous fat transplantation in the treatment of velopharyngeal insufficiency has the advantages of good histocompatibility, small local trauma, few complications, reversible operation and simple postoperative nursing, which can effectively increase the velopharyngeal closure area. If the clinical effect is poor, other surgical methods can be used at any time for replacement. Although there are many advantages in the treatment of velopharyngeal insufficiency with autologous fat transplantation, there are still some problems in the selection of indication, donor site, injection dose, recipient site, follow-up evaluation, complications and prevention and treatment. Current research shows that autologous fat transplantation is mainly used in patients with mild or moderate velopharyngeal insufficiency, but with the improvement of fat acquisition and treatment techniques, the indications for autologous fat transplantation continue to expand, and autologous fat transplantation combined with palatoplasty or pharyngoplasty has been proposed for the treatment of severe velopharyngeal insufficiency. However, there are complications, such as fat absorption and obstructive sleep apnea syndrome. In addition, the application of autologous fat transplantation in severe VPI patients and how to improve the long-term stability of autologous fat transplantation need further study.

Key words: autologous fat transplantation, velopharyngeal insufficiency, cleft palate, autologous fat transplantation, indications, donor site, velopharyngeal insufficiency, cleft palate, injection dose, recipient site, indications, complications, donor site, injection dose, recipient site, complications

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