口腔疾病防治 ›› 2021, Vol. 29 ›› Issue (3): 202-205.DOI: 10.12016/j.issn.2096-1456.2021.03.011

• 综述 • 上一篇    下一篇

聚乳酸-羟基乙酸共聚物在牙髓疾病治疗中的应用前景

周芳洁(),何利邦,李继遥()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科, 四川 成都(610041)
  • 收稿日期:2020-04-03 修回日期:2020-05-19 出版日期:2021-03-20 发布日期:2021-01-12
  • 通讯作者: 李继遥
  • 作者简介:周芳洁,学士,Emai:758309437@qq.com
  • 基金资助:
    四川省科技计划项目(2017SZ0030)

Application of poly(lactic-co-glycolic acid) in the treatment of pulp diseases

ZHOU Fangjie(),HE Libang,LI Jiyao()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-04-03 Revised:2020-05-19 Online:2021-03-20 Published:2021-01-12
  • Contact: Jiyao LI
  • Supported by:
    Science and Technology Project of Sichuan Province(2017SZ0030)

摘要:

材料学的发展对牙髓疾病的治疗有重要意义,聚乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]是一种被广泛应用于生物医用材料制备的有机高分子化合物。近年来,作为载药/分子系统和组织再生支架在牙髓疾病治疗中展现出应用前景,本文将对PLGA在牙髓疾病治疗中的应用作一综述,为其进一步开发利用提供参考。文献复习结果表明,PLGA作为药物/分子输送系统主要应用于盖髓材料、根管消毒剂和根尖诱导成形剂的改良。PLGA改良盖髓材料能延长药物作用时间、降低毒性;改良根管消毒剂能实现药物缓释,使药物深入更细微的结构,与致病菌有更广泛的接触;改良根尖诱导成形剂能为根尖诱导提供更便捷的给药方式。PLGA作为组织工程支架主要应用于牙髓再生的研究,通过PLGA物理性能、作用环境的不断优化为种子细胞提供更适宜增殖分化的微环境。如何合理利用PLGA的优势,研制出更适宜根管内应用的材料,还需要进一步的研究。

关键词: 聚乳酸-羟基乙酸共聚物, 牙髓疾病, 活髓保存治疗, 盖髓材料, 根管治疗, 根管内封药, 根尖诱导成形术, 牙髓再生, 支架

Abstract:

The development of materials science is of great significance to the treatment of dental pulp diseases. Poly lactic acid glycolic acid (PLGA) copolymer is an organic macromolecule compound that is widely used in the preparation of biomedical materials. In recent years, PLGA, as a drug/molecular loaded system and tissue regeneration scaffold, has shown prospects for application in the treatment of dental pulp diseases. This paper will review the application of PLGA in the treatment of dental pulp diseases and provide a basis for its further development and utilization. The results of the literature review show that PLGA is a drug/molecular delivery system that is mainly used in the improvement of pulp capping materials, root canal disinfectant and apexification materials. PLGA-improved pulp capping agents can prolong the action time of the drug and reduce toxicity. The modified root canal disinfectant can realize the sustained release of drug, make the drug penetrate deeper into the subtle structure, and contact more widely with the pathogenic bacteria. The modified apexification materials can provide more convenient administration methods for apexifixment. As a scaffold for tissue engineering, PLGA is mainly used in the study of pulp regeneration. The optimization of PLGA physical properties and action environment can provide a more suitable microenvironment for seed cells to proliferate and differentiate. How to utilize the advantages of PLGA to develop a more suitable material for endodontic application needs further study.

Key words: poly(lactic-co-glycolic acid), endodontics, vital pulp therapy, pulp capping materials, root canal therapy, intracanal medicament, apexification, dental pulp regeneration, scaffold

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