Journal of Prevention and Treatment for Stomatological Diseases ›› 2016, Vol. 24 ›› Issue (2): 114-117.doi: 10.12016/j.issn.2096-1456.2016.02.012

• Review Articles • Previous Articles     Next Articles

Research progress of the influence of vitamin D on periodontitis

Yan-mei YAN1,Tao HE2,Can-can MA1,Pin-xuan ZHENG1,Qi LIU1()   

  1. 1Department of Periodontology, the Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China
  • Received:2015-10-10 Revised:2015-11-11 Online:2016-02-20 Published:2016-02-20
  • Contact: Qi LIU E-mail:liuqi1964@hotmail.com

Abstract:

Vitamin D is an essential fat-soluble vitamin that can be synthesized in the human skin when exposed to sunlight or obtained through dietary means. At present, Vitamin D deficient or insufficient has become a hot topic, which not only affects the health of skeletal muscle but also promotes the occurrence and development of other diseases, such as cancer, diabetes, and periodontitis. Vitamin D supplementation can increase the bone density, inhibit the absorption of alveolar bone and reduce teeth loss. The specific mechanism may be related to bone metabolism or immune regulation of vitamin D. This review focuses on the research progress of the influence of vitamin D on periodontitis.

Key words: Vitamin D, Vitamin D receptor, Periodontitis, Immune regulation.

CLC Number: 

  • R781.4
[1] Khadilkar VV, Khadilkar AV . Use of vitamin d in various disorders[J]. Indian J Pediatr, 2013,80(3):215-218.
doi: 10.1007/s12098-012-0877-7 pmid: 22956345
[2] Martelli FS, Martelli M, Rosati C , et al. Vitamin D: relevance in dental practice[J]. J Bone Miner Metab, 2014,11(1):15-19.
doi: 10.1016/j.archoralbio.2011.06.012. pmid: 4064435
[3] 洪琼, 徐建 . 1,25-二羟基维生素D3与其受体在类风湿关节炎中的作用研究进展[J]. 安徽医学, 2012,33(3):371-373.
doi: 10.3969/j.issn.1000-0399.2012.03.048
[4] Gorham ED, Garland CF, Garland FC , et al. Vitamin D and prevention of colorectal cancer[J]. J Steroid Biochem Mol Biol, 2005,97(1/2):179-194.
doi: 10.1016/j.jsbmb.2005.06.018 pmid: 16236494
[5] Pittas AG, Harris SS, Stark PC , et al. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults[J]. Diabetes Care, 2007,30(4):980-986.
doi: 10.2337/dc06-1994
[6] Urashima M, Segawa T, Okazaki M , et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in school children[J]. Am J Clin Nutr, 2010,91(5):1255-1260.
doi: 10.3945/ajcn.2009.29094
[7] Bischoff-Ferrari HA, Willett WC, Orav EJ , et al. A pooled analysis of vitamin D dose requirements for fracture prevention[J]. N Engl J Med, 2012,367(1):40-49.
doi: 10.1097/01.ogx.0000422963.79411.8f pmid: 22762317
[8] Adegboye AR, Boucher BJ, Kongstad J , et al. Calcium, vitamin D, casein and whey protein intakes and periodontitis among Danish adults[J]. Public Health Nutr, 2015,11(5):1-8.
doi: 10.1017/S1368980015001202 pmid: 25936381
[9] Gombart AF, Borregaard N, Koeffler HP . Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3[J]. Faseb J, 2005,19(9):1067-1077.
doi: 10.1096/fj.04-3284com
[10] Dietrich T, Joshipura KJ, Dawson-Hughes B , et al. Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US Population[J]. Am J Clin Nutr, 2004,80(1):108-113.
doi: 10.1079/PHN2004649 pmid: 15213036
[11] Taubman MA, Valverde P, Han X , et al. Immune response:the key to bone resorption in periodontal disease[J]. J Periodontol, 2005,76(11):2033-2041.
doi: 10.1902/jop.2005.76.11-S.2033 pmid: 16277573
[12] Bikle DD . Vitamin D and bone[J]. Curr Osteoporos Rep, 2012,10(2):151-159.
doi: 10.1007/s11914-012-0098-z
[13] Alshouibi EN, Kaye EK, Cabral HJ , et al. Vitamin D and periodontal health in older men[J]. J Dent Res, 2013,92(8):689-693.
doi: 10.1177/0022034513495239 pmid: 23788610
[14] Dietrich T, Nunn M, Dawson-Hughes B , et al. Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation[J]. Am J Clin Nutr, 2005,82(3):575-580.
doi: 10.1021/np070206e pmid: 16155270
[15] Boggess KA, Espinola JA, Moss K , et al. Vitamin D status and periodontal disease among pregnant women[J]. J Periodontol, 2011,82(2):195-200.
doi: 10.1902/jop.2010.100384 pmid: 20809861
[16] Garcia MN, Hildebolt CF, Miley DD , et al. One-year effects of vitamin D and calcium supplementation on chronic periodontitis[J]. J Periodontol, 2011,82(1):25-32.
doi: 10.1902/jop.2010.100207 pmid: 20809866
[17] Naito M, Miyaki K, Naito T , et al. Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men[J]. Int J Med Sci, 2007,4(4):216-222.
doi: 10.7150/ijms.4.216 pmid: 17848979
[18] 刘琼, 黄建生, 徐平平 , 等. 维生素D受体基因TagI和BsmI位点单核苷酸多态性与种植体周围炎的易感性研究[J]. 广东牙病防治, 2011,19(5):249-253.
[19] 曾宪莉, 赵红宇 . 1, 25-二羟维生素D3在口腔医学领域的研究进展[J]. 广东牙病防治, 2010,18(2):106-108.
[20] 许崇游, 马艳华, 盛君曼 , 等. 降钙素和1, 25维生素D拮抗牙周炎大鼠牙槽骨丧失的疗效观察[J]. 天津医药, 2014,42(1):68-70.
doi: 10.3969/j.issn.0253-9896.2014.01.021
[21] Perayil J, Menon KS, Kurup S , et al. Influence of vitamin D & calcium supplementation in the management of periodontitis[J]. J Clin Diagn Res, 2015,9(6):35-38.
[22] Alshouibi EN, Kaye EK, Cabral HJ , et al. Vitamin D and periodontal health in older men[J]. J Dent Res, 2013,92(8):689-693.
doi: 10.1177/0022034513495239 pmid: 23788610
[23] Graves DT, Oates T, Garlet GP , et al. Review of osteoimmunology and the host response in endodontic and periodontal lesions[J/OL]. J Oral Microbiol, 2011[ 2015- 08- 05]. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087239/.
doi: 10.3402/jom.v3i0.5304 pmid: 3087239
[24] Chun RF, Adams JS, Hewison M . Back to the future:a new look at’old’vitamin D[J]. J Endocrinol, 2008,198(2):261-269.
doi: 10.1677/JOE-08-0170
[25] Wang TT, Nestel FP, Bourdeau V , et al. Cutting edge:1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression[J]. J Immunol, 2004,173(5):2909-2912.
doi: 10.4049/jimmunol.173.5.2909
[26] Youssef DA, Miller CW, El-Abbassi AM , et al. Antimicrobial implications of vitamin D[J]. Dermatoendocrinol, 2011,3(4):220-229.
doi: 10.4161/derm.3.4.15027 pmid: 3256336
[27] Yim S, Dhawan P, Ragunath C , et al. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D3[J]. J Cyst Fibros, 2007,6(6):403-410.
doi: 10.1016/j.jcf.2007.03.003 pmid: 17467345
[28] 刘俊臣, 徐道华 . 1, 25(OH)2D3免疫调节作用的研究进展[J]. 医学综述, 2013,19(15):2695-2698.
doi: 10.3969/j.issn.1006-2084.2013.15.003
[29] Bikle DD . Vitamin D and the immune system:role in protectionagainst bacterial infection[J]. Curr Opin Nephrol Hypertens, 2008,17(4):348-352.
doi: 10.1097/MNH.0b013e3282ff64a3 pmid: 18660668
[30] Baeke F, Takiishi T, Korf H , et al. Vitamin D: modulator of the immune system[J]. Curr Opin Pharmacol, 2010,10(4):482-496.
doi: 10.1016/j.coph.2010.04.001 pmid: 20427238
[31] John H . Vitamin D metabolism and signaling in the immune system[J]. Rev Endocr Metab Disord, 2012,13(1):21-29.
doi: 10.1007/s11154-011-9195-z pmid: 21845364
[32] Reich KM, Fedorak RN, Madsen K , et al. Vitamin D improves inflammatory bowel disease outcomes: Basic science and clinical review[J]. World J Gastroenterol, 2014,20(17):4934-4947.
doi: 10.3748/wjg.v20.i17.4934 pmid: 4009525
[33] Cantorna MT, Snyder L, Lin YD , et al. Vitamin D and 1,25(OH)2D regulation of T cells[J]. Nutrients, 2015,7(4):3011-3021.
doi: 10.3390/nu7043011 pmid: 25912039
[34] Matilainen JM, Husso T, Toropainen S , et al. Primary effect of 1a, 25-(OH)2D3 on IL-10 expression in monocytes is short term down-regulation[J]. Biochim Biophys Acta, 2010,1803(11):1276-1286.
doi: 10.1016/j.bbamcr.2011.09.007 pmid: 20691220
[35] Dietrich T, Joshipura KJ, Dawson-Hughes B , et al. Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population[J]. Am J Clin Nutr, 2014,80(1):108-113.
doi: 10.1079/PHN2004649 pmid: 15213036
[36] Amano Y, Komiyama K, Makishima M . Vitamin D and periodontal disease[J]. J Oral Sci, 2009,51(1):11-20.
doi: 10.2334/josnusd.51.11 pmid: 19325195
[37] Ross AC, Taylor CL, Yaktine AL . Dietary references intakes for calcium and vitamin D[J]. Pediatrics, 2012,130(5):1-4.
doi: 10.1542/peds.2012-1014
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