Journal of Prevention and Treatment for Stomatological Diseases ›› 2016, Vol. 24 ›› Issue (3): 150-153.doi: 10.12016/j.issn.2096-1456.2016.03.005

• Basic Study • Previous Articles     Next Articles

Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning

Zeng-wen YUE1,Jin-zhong LIU1(),Bao-yu ZHU1,Zheng-guang CHEN2   

  1. 1. the Fourth Affiliated Hospital of Zhengzhou University. Zhengzhou 450052, China
  • Received:2015-11-06 Revised:2015-11-24 Online:2016-03-20 Published:2016-03-20

Abstract:

Objective To investigate the expression of TKTL1 (transketolase-like protein 1) gene and its correlation with clinicopathological characteristics and prognosis of human tongue squamous cell carcinoma.Methods Immunohistochemistry was used to detect the TKTL1 protein levels in 45 human tongue cancer specimens and matched normal tissues.Results The positive expression ratio of TKTL1 protein in tongue squamous carcinoma tissues (68.89%) was significantly higher than that in normal tissues (15.56%), and the difference was statistically significant (χ 2=26.235, P<0.01). The high level of TKTL1 was not statistically correlated with age, gender and tumor differentiated degree (P>0.05), however it was associated with TNM staging and lymph node metastasis (P<0.05) notably. Mantel-Cox demonstrated the survival time of patients with high TKTL1 expression was significantly lower than those with low TKTL1 expressions. Conclusion It suggests a high TKTL1 expression may be tightly related to the occurrence, development, progression and prognosis of human tongue squamous cell carcinoma.

Key words: Transketolase-like protein 1, Tongue, Squamous cell carcinoma, Clinicopathological characteristics, Prognosis

CLC Number: 

  • R739.86

"

"

部位 n 阳性 阴性
舌正常上皮组织 45 7 38
舌鳞状细胞癌组织 45 31 14

"

临床病理学参数 n 阳性 阴性 阳性表达率(%) χ2 P
年龄(岁) ≤50 14 8 6 57.1
>50 31 23 8 74.2 1.308 0.253
性别 25 18 7 72.0
20 13 7 65.0 0.254 0.614
组织分化 11 7 4 63.6
18 12 6 66.7
16 12 4 75.0 0.462 0.794
TNM分期 Ⅰ期和Ⅱ期 21 10 11 47.6
Ⅲ期和Ⅳ期 24 21 3 87.5 8.312 0.004
淋巴结转移 阳性 20 18 2 90.0
阴性 25 13 12 52.0 7.486 0.006

"

[1] Parkin DM, Pisani P, Ferlay J . Estimates of the worldwide incidence of 25 major cancers in 1990[J]. Int J Cancer, 1999,80(6):827-841.
[2] 吴开柳, 李思毅, 张陈平 . 舌鳞状细胞癌颈淋巴结转移的特点和评估处理[J]. 国际口腔医学杂志, 2015,42(1):119-122.
[3] Warburg O . On the origin of cancer cells[J]. Science, 1956,123(3191):309-314.
doi: 10.1126/science.123.3191.309 pmid: 13298683
[4] Comin-Anduix B, Boren J, Martinez S , et al. The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study[J]. Eur J Biochem, 2001,268(15):4177-4182.
doi: 10.1046/j.1432-1327.2001.02329.x pmid: 11488910
[5] Langbein S, Zerilli M, Zur HA , et al. Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted[J]. Br J Cancer, 2006,94(4):578-585.
doi: 10.1038/sj.bjc.6602962 pmid: 2361175
[6] Krockenberger M, Honig A, Rieger L , et al. Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases[J]. Int J Gynecol Cancer, 2007,17(1):101-106.
doi: 10.1111/j.1525-1438.2007.00799.x pmid: 17291239
[7] Langbein S , Frederiks WM, zur Hausen A, et al. Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer[J]. Int J Cancer, 2008,122(11):2422-2428.
doi: 10.1002/ijc.23403 pmid: 18302154
[8] 彭参, 陈仲伟, 徐冬贵 , 等. CD1a和CD83在舌鳞癌中的表达及意义[J]. 广东牙病防治, 2014,22(6):294-297.
[9] Liu H, Shi G, Liu X , et al. Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma[J]. Oncol Rep, 2011,25(3):841-848.
doi: 10.3892/or.2010.1122 pmid: 21186404
[10] Weng G, Bhalla US, Iyengar R . Complexity in biological signaling systems[J]. Science, 1999,284(5411):92-96.
[11] Furuta E1, Okuda H, Kobayashi A , et al. Metabolic genes in cancer: their roles in tumor progression and clinical implications[J]. Biochim Biophys Acta, 2010,1805(2):141-52.
[12] Coy JF, Dubel S, Kioschis P , et al. Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes[J]. Genomics, 1996,32(3):309-316.
doi: 10.1006/geno.1996.0124 pmid: 8838793
[13] Song Y, Liu D, He G . TKTL1 and p63 are biomarkers for the poor prognosis of gastric cancer patients[J]. Cancer Biomark, 2015,15(5):591-597.
doi: 10.3233/CBM-150499 pmid: 26406948
[14] Shi Z, Tang Y, Li K , et al. TKTL1 expression and its downregulation is implicated in cell proliferation inhibition and cell cycle arrest in esophageal squamous cell carcinoma[J]. Tumour Biol, 2015,36(11):8519-8529.
doi: 10.1007/s13277-015-3608-7 pmid: 26032094
[15] Li J, Zhu SC, Li SG , et al. TKTL1 promotes cell proliferation and metastasis in esophageal squamous cell carcinoma[J]. Biomed Pharmacother, 2015,34(74):71-76.
doi: 10.1016/j.biopha.2015.07.004 pmid: 26349965
[16] Kayser G, Sienel W, Kubitz B , et al. Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression[J]. Pathology, 2011,43(7):719-724.
doi: 10.1097/PAT.0b013e32834c352b pmid: 22027741
[17] Fritz P, Coy JF, Murdter TE , et al. TKTL-1 expression in lung cancer[J]. Pathol Res Pract, 2012,208(4):203-209.
doi: 10.1016/j.prp.2012.01.007 pmid: 22445516
[1] ZHONG qijian,JIN Tingting,PENG Yu,CHEN Weixiong,LI Jinsong. The effect of silencing the endoplasmic reticulum stress-related protein calnexin on the proliferation, invasion, and migration of tongue squamous cell carcinoma cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(8): 535-540.
[2] WU Buling,LUO Yifei,XU Wenan,TONG Zhongchun. Vital pulp therapy of pulp inflammation of permanent teeth [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(7): 433-441.
[3] WANG Qianqian,DING Dandan,DING Xiang,HAN Rui,HAN Yingying,ZHOU Meiyun,XU Jincheng. Expression of Bex1 and NF-kBp65 in tongue squamous cell carcinoma and its significance [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(6): 383-387.
[4] LI Ming,NAN Xinrong,YUAN Zhenying,TANG Zhangui. Accuracy analysis of MRI in the depth of invasion assessment of tongue squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(5): 322-327.
[5] WANG Anxun. Detection and significance of immune function in oral mucosa-associated diseases [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(2): 73-80.
[6] YANG Hui,WANG Xiang,ZHANG Lei,WANG Wenmei,DUAN Ning,LI Ruowei,ZHANG Miaomiao. Clinical analysis of 19 cases of oral mucosal malignant melanoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(12): 843-847.
[7] CHEN Zhen,ZHANG Wenbo,PENG Xin. Research progress on the neck management of oral squamous cell carcinoma with clinically node-positive neck [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(11): 776-781.
[8] WANG Guangchao,LIU Lijun,JIANG Weiwen. Significance of phosphoinositol metabolism by DNA methylation may contribute in oral leukoplakia carcinogenesis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(10): 677-683.
[9] ZENG Fei,LU Jie,SUN Renhao,FANG Yikang,YU Wenyi,YANG Fang,ZHAO Lu. Research progress on programmed death receptor 1/ ligand 1 inhibitor in immunotherapy of head and neck squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(10): 706-710.
[10] WANG Liye,GAO Ying,TIAN Chun. Identification of potential genetic markers in prognosis of oral squamous cell carcinoma patients by bioinformatic analysis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(1): 27-33.
[11] ZHANG Qianyu,YANG Peixin,CHEN Boshen,WANG lin,HUANG Zhiquan. Synchronous double primary malignant tumours of the tongue and lung: a case report and literature review [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(9): 586-589.
[12] CHEN Shuwei,YANG Ankui,ZHANG Quan,CHEN Wenkuan,LI Hao,LI Qiuli,CHEN Yanfeng,CHEN Weichao,YANG Zhongyuan,ZHANG Xing,SONG Ming. Analysis of clinicopathological characteristics and survival of 1 915 oral cavity squamous cell carcinoma patients: 24-year experience from a single institution [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(8): 487-493.
[13] CAO Shunshun,WANG Xiaolong,SHU Chuanji,SHAO Jianjie. Inhibitory effect of celecoxib on Cal-27 tongue squamous cell carcinoma cell proliferation [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(7): 427-432.
[14] ZHANG Haifeng,NAN Xinrong,HUA Yongqing. Research progress on the consistency and evaluation factors of cervical lymphatic metastasis in early tongue cancer [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(5): 336-340.
[15] ZENG Fantao,YU Dongsheng. Knockdown of circ_0001273 inhibits the proliferation, migration and invasion of oral squamous cell carcinoma cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(3): 153-157.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] ZHU Song-song, HU Jing. The application of distraction osteogenesis in the temporomandibular joint ankylosis and secondary dentofacial deformities[J]. journal1, 2016, 24(1): 6 -10 .
[2] XU Jing. The influence of the impacted mandibular third molar extraction on the distal periodontal tissue of the mandibular second molar[J]. journal1, 2016, 24(1): 11 -14 .
[3] ZHONG Jiang-long, PAN Ji-yang, CHEN Wei-liang. The evaluation of Eagle syndrome treatment by surgery combined with antidepressant therapy[J]. journal1, 2016, 24(1): 26 -28 .
[4] CHEN Xi, SUN Qin-zhou. The study of colorimetric board of porcelain fused to metal restoration for moderate to severe dental fluorosis[J]. journal1, 2016, 24(1): 33 -36 .
[5] OUYANG Ke-xiong1, LIANG Jun, ZOU Rui, LI Zhi-qiang, BAI Zhi-bao, PIAO Zheng-guo, ZHAO Jian-Jiang.. Ion Torrent RNA-Seq detection and analysis of the long non-coding RNA in tongue squamous cell carcinoma[J]. journal1, 2016, 24(1): 15 -19 .
[6] YU Pei, XUE Jing, ZHANG Xiao-wei, ZHENG Cang-shang. The influence of the roughness of zirconia ceramic surface on microbial attachment[J]. journal1, 2016, 24(1): 20 -25 .
[7] LIU Fang. Clinical assessment of two fissure sealant techniques in children’s dental caries prevention[J]. journal1, 2016, 24(1): 44 -45 .
[8] . [J]. journal1, 2016, 24(1): 49 -52 .
[9] LU Jian-rong, BAN Hua-jie, WANG Dai-you, ZHOU Hui-hui, LONG Ru, QIN Shu-hua. Clinical observation of sternocleidomastoid muscle flaps combined with artificial biological membrane reparing the defects after parotidectomy[J]. journal1, 2016, 24(1): 29 -32 .
[10] LI Bin, HE Xiao-ning, GAO Yuan, HU Yu-ping. Clinical analysis of pain after two kinds of apical stop preparation[J]. journal1, 2016, 24(1): 40 -43 .
This work is licensed under a Creative Commons Attribution 3.0 License.