Journal of Prevention and Treatment for Stomatological Diseases ›› 2016, Vol. 24 ›› Issue (6): 356-361.doi: 10.12016/j.issn.2096-1456.2016.06.009

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Low-level laser therapy for accelerating orthodontic tooth movement: a Meta-analysis and systematic review

Wu-lin HE1,Yuan ZHOU2,Shuo YANG1,Jun WEN1,Hong-xing CHU1,Meng-ke GE3,Pei-jia DUAN1()   

  1. 1. Guangdong Provincial Stomatological Hospital, the Affiliated Stomatological Hospital of Southern Medical University, Guangzhou 510280, China
  • Received:2016-01-15 Revised:2016-03-10 Online:2016-06-20 Published:2016-06-20
  • Contact: Pei-jia DUAN E-mail:duanpeijia@sina.com

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Abstract:

Objective To evaluate the efficacy and related risk of low level laser therapy (LLLT) for accelerating tooth movement during orthodontic treatment.Methods An extensive electronic search was conducted by two reviewers. Randomized controlled trials (RCTs) and quasi-RCTs concerning the efficacy of LLLT for accelerating tooth movement during orthodontic treatment were searched in CENTRAL, PubMed, Medline, Embase, CBM, CNKI.Results Six RCTs and three quasi-RCTs, involving 211 patients from six countries, were selected from 173 relevant studies. All nine articles were feasible for the systematic review and meta-analysis, five of which were assessed as moderate risk of bias, while the rest were assessed as high risk of bias. The mean difference and the 95 % confidence interval (95 % CI) of accumulative moved distance of teeth were observed among all the researches. The results showed that the LLLT could accelerate orthodontic tooth movement in 7 days (MD = 0.19, 95% CI 0.02-0.37, P = 0.03) and 2 months (MD = 1.08, 95% CI 0.16-2.01, P = 0.02). Moreover, a relatively lower energy density (2.5, 5 and 8 J/cm 2) was seemingly more effective than 20 and 25 J/cm 2 and even higher ones. Conclusion This systematic review and meta-analysis demonstrated that LLLT might speed up the tooth movement in orthodontic treatment. A relatively lower energy density (2.5, 5, and 8 J/cm 2) was seemingly more effective than higher ones. More qualified RCTs in human subjects are required.

Key words: Low-level laser therapy, Orthodontics, Tooth movement, Meta-analysis, Systematic review

CLC Number: 

  • R783.5

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作者年代 国家 研究设计 样本量（I/C） 牙移动测量方式 正畸力 随访周期
Cruz 2004[5] 巴西 RCT, split-mouth design 11/11 电子游标卡尺口内测量 初始力值150 g （每月重新激活一次） 2个月
Limpanichkul
2006[9]		 泰国 RCT, split-mouth design 12/12 立体显微镜测量石膏模型 初始力值150 g （每月重新激活一次） 3个月
徐成伟2006[12]
 中国 quasi-RCT,
split-mouth design		 36/36 电脑扫描石膏模型后测量 初始力值1.37 N 21 d
王铁军 2007[11] 中国 RCT, split-mouth design 17/17 游标卡尺石膏模型上测量 初始力值125 g 8 周
Youssef 2008[13] 叙利亚 quasi-RCT
split-mouth design		 30/30 电子游标卡尺测量石膏模型 初始力值150 g（21 d重新激活一次） 9 周
Fujiyama 2008[7] 日本 RCT 60/30 电子游标卡尺测量石膏模型 上6近远中放置分牙圈 7 d
贵林2008[8] 中国 quasi-RCT
split-mouth design		 20/20 游标卡尺石膏模型上测量 初始力值150 g 28 d
Sousa 2011[10] 巴西 RCT, split-mouth design 13/13 电脑扫描石膏模型后使用
Geomagic Studio 5 软件测量		 初始力值150 g （每月重新激活一次） 3 月
Doshi-Mehta 2012[6] 印度 RCT, split-mouth design 30/30 电子游标卡尺测量石膏模型 初始力值150 g 4.5个月

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作者年代 激光种类 波长/能量密度 功率/每牙照射时间 激光照射频率
* Limpanichkul 2006[9] GaAlAs 半导体 激光 860 nm, 25J/cm2 100 mW
184 s/tooth		 每月第1、2、3 d照射,连续3个月
*贵林2008[8] GaAlAs 半导体 激光 650 nm
25 J/cm2		 20 mW
1200s		 每周照射1次,连续4周
* Doshi-Mehta 2012[6] GaAlAs 半导体 激光 810 nm
20 J/cm2		 80 mW
100 s/tooth		 每15 d内的第0、3、7、14 d照射,连续 4.5个月
**Youssef 2008[13] GaAlAs 半导体 激光 809 nm,
8 J/cm2		 100 mW
80 s/tooth		 每21 d内的第0、3、7、14 d照射,连续 9 周
** Cruz 2004[5] GaAlAs 半导体 激光 780 nm
5 J/cm2		 20 mW
100 s/tooth		 每月第0、3、7、14 d照射,连续 2个月
**王铁军 2007[11] GaAlAs 半导体 激光 780 nm
5 J/cm2		 20 mW
100 s/tooth		 每周1次,连续8周
**Sousa 2011[10] GaAlAs 半导体 激光 780 nm
5 J/cm2		 20 mW
100 s/tooth		 每月第0、3、7 d,连续4个月
徐成伟2006[12] He-Ne 激光 632 nm
2.5J/cm2		 20 mW 21 d内的第 1、2、3、4、5 d
Fujiyama 2008[7] CO2激光 未描述 2 W
60 s/tooth		 分牙后立即照射一次
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