Journal of Prevention and Treatment for Stomatological Diseases ›› 2016, Vol. 24 ›› Issue (6): 374-377.doi: 10.12016/j.issn.2096-1456.2016.06.014

• Review Articles • Previous Articles     Next Articles

The research progress of dental pulp regeneration

Zhong-juan TAN,Yue-ping ZHAO(),Yuan-yuan LUO   

  1. Medical College of Jinan University, Guangzhou 510632, China
  • Received:2015-11-29 Revised:2016-01-02 Online:2016-06-20 Published:2016-06-20
  • Contact: Yue-ping ZHAO E-mail:13450488226@163.com

Abstract:

Living pulp is crucial for the maintenance of tooth homeostasis. An ideal form should consist of regenerative approaches, which necrotic pulp or diseased tissues are replaced with regenerated pulp tissues, and the tooth converts into vital in the end. With the development of tissue engineering, dental pulp regeneration becomes possible. This review will solve and discuss the problems of dental pulp regeneration from stem cells, scaffolds and growth factors.

Key words: Dental pulp regeneration, Stem cells, Scaffold, Growth factors, Tissue engineering

CLC Number: 

  • R781.3
[1] Yildirim S, Fu SY, Kim K , et al. Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine[J]. Int J Oral Sci, 2011,3(3):107-116.
doi: 10.4248/IJOS11042 pmid: 3470096
[2] Huang GT . Dental pulp and dentin tissue engineering and regeneration-advancement and challenge[J]. Front Biosci (Elite Ed), 2011,3(2):788-800.
doi: 10.2741/e286 pmid: 21196351
[3] Goldberg M . Pulp healing and regeneration: more questions than answers[J]. Adv Dent Res, 2011,23(3):270-274.
doi: 10.1177/0022034511405385
[4] Egusa H, Sonoyama W, Nishimura M , et al. Stem cells in dentistry-part Ⅰ: stem cell sources[J]. J Prosthodont Res, 2012,56(3):151-165.
doi: 10.1016/j.jpor.2012.06.001 pmid: 22796367
[5] Huang GT . Pulp and dentin tissue engineering and regeneration: current progress[J]. Regen Med, 2009,4(5):697-707.
doi: 10.2217/rme.09.45 pmid: 2785543
[6] Gronthos S, Mankani M, Brahim J , et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo[J]. Proc Natl Acad Sci U S A, 2000,97(25):13625-13630.
doi: 10.1073/pnas.240309797 pmid: 11087820
[7] Cordeiro MM, Dong Z, Kaneko T , et al. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth[J]. J Endod, 2008,34(8):962-969.
doi: 10.1016/j.joen.2008.04.009 pmid: 18634928
[8] Mao JJ, Kim SG, Zhou J , et al. Regenerative endodontics: barriers and strategies for clinical translation[J]. Dent Clin North Am, 2012,56(3):639-649.
doi: 10.1016/j.cden.2012.05.005
[9] Alongi DJ, Yamaza T, Song Y , et al. Stem/progenitor cells from inflamed human dental pulp retain tissue regeneration potential. Regen Med, 2010,5(4):617-631.
doi: 10.2217/rme.10.30 pmid: 3035701
[10] Huang GT, Al-Habib M, Gauthier P . Challenges of stem cell-based pulp and dentin regeneration: a clinical perspective[J]. Endod Topics, 2013,28(1):51-60.
doi: 10.1111/etp.12035 pmid: 23914150
[11] Cai J, Zhang Y, Liu P , et al. Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells[J]. Cell Regen (Lond), 2013,2(1):6.
doi: 10.1186/2045-9769-2-6 pmid: 4230506
[12] Huo N, Tang L, Yang Z , et al. Differentiation of dermal multipotent cells into odontogenic lineage induced by embryonic and neonatal tooth germ cell-conditioned medium[J]. Stem Cells Dev, 2010,19(1):93-104.
doi: 10.1089/scd.2009.0048 pmid: 19469666
[13] Kim JY, Xin X, Moioli EK , et al. Regeneration of dental-pulp-like tissue by chemotaxis-induced cell homing[J]. Tissue Eng Part A, 2010,16(10):3023-3031.
doi: 10.1089/ten.TEA.2010.0181 pmid: 2947424
[14] 熊华翠, 陈柯 . 组织工程牙髓的研究进展[J]. 广东牙病防治, 2013,21(1):50-54.
[15] 雷鸣, 高丽娜, 陈发明 , 等. 牙髓组织工程和再生中生物支架材料的进展[J]. 牙体牙髓牙周病学杂志, 2013,23(1):51-56.
[16] Yang X, Yang F, Walboomers XF , et al. The performance of dental PCL/gelatin/nHA scaffolds pulp stem cells on nanofibrous[J]. J Biomed Mater Res A, 2010,93(1):247-257.
[17] Nevins AJ, Cymerman JJ . Revitalization of open apex teeth with apical periodontitis using a collagen-hydroxyapatite scaffold[J]. J Endod, 2015,41(6):966-973.
doi: 10.1016/j.joen.2014.12.010 pmid: 25680956
[18] Na S, Zhang H, Huang F , et al. Regeneration of dental pulp/dentine complex with a three-dimensional and scaffold-free stem-cell sheet-derived pellet[J]. J Tissue Eng Regen Med, 2013, doi: 10.1002/term.1686.
doi: 10.1002/term.1686 pmid: 23365018
[19] Chen FM, Zhang J, Zhang M , et al. A review on endogenous regenerative technology in periodontal regenerative medicine[J]. Biomaterials, 2010, 31(31):7892-7927.
[20] Bansal R, Jain A, Mittal S . Current overview on challenges in regenerative endodontics[J]. J Conserv Dent, 2015,18(1):1-6.
doi: 10.4103/0972-0707.148861 pmid: 25657518
[21] Yang JW, Zhang YF, Sun ZY . Dental pulp tissue engineering with bFGF-incorporated silk fibroin scaffolds[J]. J Biomater Appl, 2015,30(2):221-229.
doi: 10.1177/0885328215577296 pmid: 25791684
[22] Melin M, Joffre-Romeas A, Farges JC . Effects of TGFbeta1 on dental pulp cells in cultured human tooth slices[J]. J Dent Res, 2000,79(9):1689-1696.
doi: 10.1177/00220345000790090901 pmid: 11023265
[23] He H, Yu J, Liu Y . Effects of FGF2 and TGFbeta1 on the differentiation of human dental pulp stem cells in vitro[J]. Cell Biol Int, 2008,32(7):827-834.
doi: 10.1016/j.cellbi.2008.03.013
[24] Murray PE, Garcia-Godoy F, Hargreaves KM . Regenerative endodontics: a review of current and a call for action[J]. J Endod, 2007,33(4):377-390.
doi: 10.1016/j.joen.2006.09.013 pmid: 17368324
[1] LIU Ying,YANG Jing,LI Yazhen,YAN Xiao,ZHANG Qiang,REN Dapeng,YANG Fang,YUAN Xiao,GUO Qingyuan. Effects of silencing the HIF-1α gene on the expression of BSP and osterix in rat BMMSCs under tension [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(5): 287-292.
[2] HU Huiting,YU Fenglin,ZHAO Yueping. Research progress on the factors influencing the biological characteristics of dental pulp stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(4): 268-272.
[3] XU Xiongcheng,ZHONG Quan,LUO Kai. Application of 3D printing technology in preparation of scaffolds for periodontal tissue regeneration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(3): 189-193.
[4] YIN Xiaoping,XIONG Huacui,CHEN Ke,HUANG Ying,XU Shuaimei. The effects of leptin on osteogenesis/odontogenic related gene expression of human apical papillary stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(1): 23-29.
[5] CHEN Faming,GAO Lina,CHEN Fang. Current status and progress of periodontal regeneration therapy [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(1): 9-16.
[6] Jing ZHANG, Shuangxi ZHU, Qiong RONG, Wei PENG, Xiang LI, Songling CHEN. Role of miR-27a in the osteogenic differentiation of beagle maxillary sinus membrane stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(8): 484-490.
[7] Qiaoli NIU, Yiming LI, Yanyan SONG, Chenxi LI, Jin ZHAO. Effects of different concentrations of MTA on the proliferation and differentiation of stem cells from the apical papilla [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(8): 491-495.
[8] Jing ZHANG, Shuangxi ZHU, Wei PENG, Xiang LI, Qiong RONG, Songling CHEN. Culture and identification of the osteogenic properties of beagle maxillary sinus membrane stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 422-427.
[9] Xuening GU, Jiamiao QUAN, Yuqing GUO, Song LI. cAMP-responsive-element-binding protein promotes the differentiation of human stem cells from the apical papilla via inhibition of the TGF-β1 pathway [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 428-433.
[10] Wenjing LIU, Yangpeng SUN, Hong ZHANG, Zhiguang ZHANG. Effect of IL-1β on human synovial fluid-derived mesenchymal stem cells in the temporomandibular joint [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(5): 288-296.
[11] Weimin LIN, Miao CHEN, Chen HU, Yili QU. Progress in the combined application of bone morphogenetic protein-2 and basic fibroblast growth factor in bone tissue engineering [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(5): 325-329.
[12] Xinfo PEI, Shu MENG, Yi DING. Current application of concentrated growth factors in periodontal tissue regeneration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(5): 330-333.
[13] Jun HE, Ziliang LI, Zhigang XIE. Research progress on osteoinductive properties of bone substitute materials [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(2): 124-127.
[14] Zhenyu JIN,Zhihong ZHANG. Effects of canine bone marrow stromal cells after different stages of mineralization on the differentiation, proliferation of canine periodontal ligament stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(11): 699-705.
[15] Qianli ZHANG,Chongyang YUAN,Xiaoyan WANG. Application of electrospun nanofibrous scaffolds in pulp regeneration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(11): 738-742.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!
This work is licensed under a Creative Commons Attribution 3.0 License.