Journal of Prevention and Treatment for Stomatological Diseases ›› 2016, Vol. 24 ›› Issue (10): 594-598.doi: 10.12016/j.issn.2096-1456.2016.10.007

• Cinical Study • Previous Articles     Next Articles

Association between periodontitis and preeclampsia: a Meta-analysis

Kui JI,Jie. ZHANG()   

  1. Tianjin Medical University General Hospital, Tianjin 300052, China
  • Received:2015-12-20 Revised:2016-01-05 Online:2016-10-20 Published:2016-10-20
  • Contact: Jie. ZHANG E-mail:jiezhang2410@126.com

Abstract:

Objective To explore the relationship between periodontitis and preeclampsia (PE) using Meta-analysis method.Methods The EMBASE, PubMed, CNKI, WanFang and CBM databases were searched up to Oct. 31, 2015, and the relevant references of the included studies were also retrieved manually. The literatures were screened according to the inclusion and exclusion criterias by 2 reviewers independently. The methodology quality was evaluated after data abstraction. RevMan 5.3 software was used for Meta-analyses.Results 13 studies consist of 12 case-control studies and 1 cohort study were included. A total of 5 744 patients were involved, with 1 248 preeclampsia (PE) patients and 4 496 non PE patients. Meta-analysis showed that periodontitis increased the risk of PE with 2.67 times (OR = 2.67, 95%CI = 1.56-4.57, P<0.001). 3 subgroups of periodontitis were defined by pocket probing depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP), or by PPD with BOP, or by PPD. 3 subgroup analysis all revealed periodontitis was a risk factor, and the OR values were 2.91(95%CI = 2.05-4.11, P<0.001), 2.33(95%CI = 1.28-4.26, P = 0.006) and 2.8 (95%CI = 1.11-7.09, P = 0.03) respectively. Sensitivity analysis showed the results was stable and no publication bias was detected.Conclusion Periodontitis is a significant risk factor in PE according to this Meta analysis.

Key words: Periodontitis, Preeclampsia, Meta-analysis, Case-control study, Cohort study

CLC Number: 

  • R781.4

Figure 1

Literature screening process"

Table 1

General characteristics and quality evaluation of studies included in Meta analysis"

研究 研究类型 研究地 发表时间 病例数(例) 牙周炎的定义指标 NOS OR(95%CI
PE组 非PE组
Boggess等[6] 队列 美国 2003 34 729 PPD、BOP 9 2.1(1.0~4.4)
Canakci等[7] 病例对照 土耳其 2004 41 41 PPD、CAL、BOP 9 3.47(1.07~11.95)
Contreras等[8] 病例对照 美国 2006 130 243 PPD、CAL、BOP 6 3.00(1.91~4.87)
Cota等[9] 病例对照 巴西 2006 109 479 PPD、CAL 6 1.88(1.10~3.00)
Canakci等[10] 病例对照 土耳其 2007 38 21 PPD、BOP 7 2.43(1.13~8.19)
Kunnen等[11] 病例对照 荷兰 2007 17 35 PPD、BOP 7 7.9(1.9~32.8)
Siqueira等[12] 病例对照 巴西 2008 164 1042 PPD、CAL 5 1.52(1.01~2.29)
Lohsoonthorn等[13] 病例对照 泰国 2009 150 150 PPD、CAL 6 0.92(0.26~3.28 )
Politano等[14] 病例对照 巴西 2011 58 58 PPD、CAL、BOP 7 3.73(1.32~10.58)
Taghzouti等[15] 病例对照 加拿大 2012 92 245 PPD、CAL 6 1.13(1.02~1.25)
Moura等[16] 病例对照 巴西 2012 284 290 PPD、CAL 8 2.03(1.43~2.90)
Chaparro等[17] 病例对照 智利 2013 11 43 PPD、CAL、BOP 7 1.360(0.252~7.372)
Desai等[18] 病例对照 印度 2015 120 1120 PPD、CAL 8 19.898(7.80~48.94)

Figure 2

Meta analysis on periodontitis and PE"

Figure 3

Subgroup analysis according to 3 definitions of periodontitis"

Figure 4

Bias analysis of studies included in Meta analysis"

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