Journal of Prevention and Treatment for Stomatological Diseases ›› 2016, Vol. 24 ›› Issue (11): 671-673.doi: 10.12016/j.issn.2096-1456.2016.11.010

• Prevention and Treatment Practice • Previous Articles     Next Articles

Clinical effect of iodine 125 seeds implantation combined with EGFR inhibitor for advanced squamous cell carcinoma in tongue base

WANG Xing,MENG Jian()   

  1. Department of Stomatology, Affiliated Xuzhou Hospital, College of Medicine, Southeast University, Xuzhou 221009, China
  • Received:2016-01-02 Revised:2016-03-31 Online:2016-11-20 Published:2016-11-20
  • Contact: Jian MENG E-mail:mrocket@126.com

Abstract:

Squamous cell carcinoma in tongue base is one of the most worst prognosis cancer, which usually gets into an end-stage disease. The authors report 2 cases of advanced squamous cell carcinoma in tongue base with system disease, which were treated by iodine 125 seeds implantation combined with EGFR inhibitor effectively.

Key words: Squamous cell carcinoma, Iodine 125 seeds, Targeted therapy, EGFR inhibitor, Oropharyngeal carcinoma

CLC Number: 

  • R782

Figure 1

CT image of case 1 before treatment"

Figure 2

Dose-volume histogram of case 1 after operation"

Figure 3

CT image of case 1 in 2-month follow-up"

[1] Meng J, Zhang J, Zhuang Q , et al. TPS-guided I-125 implantation in patients with oral carcinoma[J]. Eur Rev Med Pharmacol Sci, 2014,14(2):2803-2807.
[2] Meng J, Meng QF, Gu QP , et al. Radioactive seed implantation combined with prosjournal denture in treatment of oral and maxillofacial malignancy[J]. Cell Biochem Biophys, 2013,67(3):1529-1532.
doi: 10.1007/s12013-013-9656-y
[3] Cano ER, Lai SY, Caylakli F , et al. Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy[J]. Head Neck, 2009,31(11):1431-1438.
doi: 10.1002/hed.v31:11
[4] Adkins D, Ley J, Trinkaus K , et al. A phase 2 trial of induction nab- paclitaxel and cetuximab given with cisplatin and 5-fluorouracil followed by concurrent cisplatin and radiation for locally advanced squamous cell carcinoma of the head and neck[J]. Cancer, 2013,119(4):766-773.
doi: 10.1002/cncr.27741
[5] 邱蔚六 . 口腔颌面外科学[J]. 6版. 北京: 人民卫生出版社, 2010: 274-275.
[6] 冼淡, 陈巨峰, 莫础嘉 , 等. 265例舌癌的临床特点及其对肿瘤颈淋巴结转移的预测价值[J]. 广东牙病防治, 2013,21(9):461-464.
[7] Stewart BW, Coates AS . Cancer prevention: a global perspective[J]. J Clin Oncol, 2005,23(2):392-403.
doi: 10.1200/JCO.2005.05.132
[8] 王兴, 孟箭 . 125I粒子植入治疗高龄非霍奇金淋巴瘤并吞咽困难一例 [J]. 中华全科医师杂志, 2015,14(5):388-389.
[9] Khalilur R, Hayashi K, Shibuya H . Brachytherapy for tongue cancer in the very elderly is an alternative to external beamradiation[J]. Br J Radiol, 2011,84(1004):747-749.
doi: 10.1259/bjr/23130739
[10] Capdevila J, Elez E, Macarulla T , et al. Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment[J]. Cancer Treat Rev, 2009,35(4):354-363.
doi: 10.1016/j.ctrv.2009.02.001
[11] Sundvall M, Karrila A, Nordberg J , et al. EGFR targeting drugs in the treatment of head and neck squamous cell carcinoma[J]. Expert Opin Emerg Drugs, 2010,15(2):185-201.
doi: 10.1517/14728211003716442
[12] Milas L, Saja U, Liao Z , et al. Targeting molecular determinants of tumorchemo- radioresistance[J]. Semin Oncol, 2005,32(6):78-81.
doi: 10.1053/j.seminoncol.2005.04.028
[13] Pore N, Jiang Z, Gupta A , et al. EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1- dependent mechanisms[J]. Cancer Res, 2006,66(6):3197-3204.
doi: 10.1158/0008-5472.CAN-05-3090
[14] Meng J, Gu QP, Meng QF , et al. Efficacy of Nimotuzumab combined with docetaxel-cisplatin-fluorouracil regimen in treatment of advanced oral caricinoma[J]. Cell Biochem Biophys, 2014. 68(1):181-184.
doi: 10.1007/s12013-013-9686-5
[15] Rodriguez MO Rivero TC, del Castillo Bahi R, , et al. Nimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neck[J]. Cancer Biol Ther, 2010,9(5):343-349.
doi: 10.4161/cbt.9.5.10981
[1] ZHONG qijian,JIN Tingting,PENG Yu,CHEN Weixiong,LI Jinsong. The effect of silencing the endoplasmic reticulum stress-related protein calnexin on the proliferation, invasion, and migration of tongue squamous cell carcinoma cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(8): 535-540.
[2] WANG Qianqian,DING Dandan,DING Xiang,HAN Rui,HAN Yingying,ZHOU Meiyun,XU Jincheng. Expression of Bex1 and NF-kBp65 in tongue squamous cell carcinoma and its significance [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(6): 383-387.
[3] LI Ming,NAN Xinrong,YUAN Zhenying,TANG Zhangui. Accuracy analysis of MRI in the depth of invasion assessment of tongue squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(5): 322-327.
[4] WANG Anxun. Detection and significance of immune function in oral mucosa-associated diseases [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(2): 73-80.
[5] CHEN Zhen,ZHANG Wenbo,PENG Xin. Research progress on the neck management of oral squamous cell carcinoma with clinically node-positive neck [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(11): 776-781.
[6] WANG Guangchao,LIU Lijun,JIANG Weiwen. Significance of phosphoinositol metabolism by DNA methylation may contribute in oral leukoplakia carcinogenesis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(10): 677-683.
[7] ZENG Fei,LU Jie,SUN Renhao,FANG Yikang,YU Wenyi,YANG Fang,ZHAO Lu. Research progress on programmed death receptor 1/ ligand 1 inhibitor in immunotherapy of head and neck squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(10): 706-710.
[8] WANG Liye,GAO Ying,TIAN Chun. Identification of potential genetic markers in prognosis of oral squamous cell carcinoma patients by bioinformatic analysis [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(1): 27-33.
[9] CHEN Yongju,HUANG Zixian,CHEN Rui,CHEN Weiliang. Research progress on HPV-positive oropharyngeal carcinoma sensitive to radiation therapy [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(1): 65-68.
[10] TAO Qian,YANG Yaocheng. Logic and clinical significance of the new WHO classification of ameloblastoma in 2017 [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(7): 416-420.
[11] CAO Shunshun,WANG Xiaolong,SHU Chuanji,SHAO Jianjie. Inhibitory effect of celecoxib on Cal-27 tongue squamous cell carcinoma cell proliferation [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(7): 427-432.
[12] ZHANG Haifeng,NAN Xinrong,HUA Yongqing. Research progress on the consistency and evaluation factors of cervical lymphatic metastasis in early tongue cancer [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(5): 336-340.
[13] LI Xiaodong,MENG Jian. Application progress of recombinant human endostatin in the treatment of head and neck cancer [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(4): 267-272.
[14] ZENG Fantao,YU Dongsheng. Knockdown of circ_0001273 inhibits the proliferation, migration and invasion of oral squamous cell carcinoma cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(3): 153-157.
[15] QIN Lingling,CHEN Ying,SU Miao,ZHANG Hanbin. Prognostic impacts of marital status on patients with buccal mucosa squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(11): 718-722.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] ZHU Song-song, HU Jing. The application of distraction osteogenesis in the temporomandibular joint ankylosis and secondary dentofacial deformities[J]. journal1, 2016, 24(1): 6 -10 .
[2] XU Jing. The influence of the impacted mandibular third molar extraction on the distal periodontal tissue of the mandibular second molar[J]. journal1, 2016, 24(1): 11 -14 .
[3] ZHONG Jiang-long, PAN Ji-yang, CHEN Wei-liang. The evaluation of Eagle syndrome treatment by surgery combined with antidepressant therapy[J]. journal1, 2016, 24(1): 26 -28 .
[4] CHEN Xi, SUN Qin-zhou. The study of colorimetric board of porcelain fused to metal restoration for moderate to severe dental fluorosis[J]. journal1, 2016, 24(1): 33 -36 .
[5] OUYANG Ke-xiong1, LIANG Jun, ZOU Rui, LI Zhi-qiang, BAI Zhi-bao, PIAO Zheng-guo, ZHAO Jian-Jiang.. Ion Torrent RNA-Seq detection and analysis of the long non-coding RNA in tongue squamous cell carcinoma[J]. journal1, 2016, 24(1): 15 -19 .
[6] YU Pei, XUE Jing, ZHANG Xiao-wei, ZHENG Cang-shang. The influence of the roughness of zirconia ceramic surface on microbial attachment[J]. journal1, 2016, 24(1): 20 -25 .
[7] LIU Fang. Clinical assessment of two fissure sealant techniques in children’s dental caries prevention[J]. journal1, 2016, 24(1): 44 -45 .
[8] . [J]. journal1, 2016, 24(1): 49 -52 .
[9] LU Jian-rong, BAN Hua-jie, WANG Dai-you, ZHOU Hui-hui, LONG Ru, QIN Shu-hua. Clinical observation of sternocleidomastoid muscle flaps combined with artificial biological membrane reparing the defects after parotidectomy[J]. journal1, 2016, 24(1): 29 -32 .
[10] LI Bin, HE Xiao-ning, GAO Yuan, HU Yu-ping. Clinical analysis of pain after two kinds of apical stop preparation[J]. journal1, 2016, 24(1): 40 -43 .
This work is licensed under a Creative Commons Attribution 3.0 License.