Journal of Prevention and Treatment for Stomatological Diseases ›› 2016, Vol. 24 ›› Issue (12): 701-704.doi: 10.12016/j.issn.2096-1456.2016.12.004

• Basic Study • Previous Articles     Next Articles

Protective effect of baicalin on oxidative stress-induced apoptosis of gingival epithelial cells

Shu-fan ZHAO,Ying-qiu CUI()   

  1. Department of Stomatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China
  • Received:2016-10-11 Revised:2016-10-29 Online:2016-12-20 Published:2016-12-20
  • Contact: Ying-qiu CUI E-mail:drcuiyingqiu@sina.com

Abstract:

Objective To study the protective effect of baicalin on oxidative stress- induced gingival epithelial cell apoptosisand its mechanism. Methods H2O2 was employed to form the oxidative stress-induced gingival epithelial cells apoptotic model, with the intervention of baicalin. The cell proliferation rate, cell apoptosis level, the protein expression of protein kinase B (Akt) and glycogen synthase kinase3β (GSK3β) were investigated respectively. Results Baicalin could effectively alleviate oxidative stress-induced inhibition of gingival epithelial cell proliferation and alleviate apoptosis; and it could promote the phosphorylation of Akt-GSK3β signaling pathway. Conclusion Baicalin has a significant protective effect on oxidative stress-induced apoptosis of gingival epithelial cells, which may be related to the regulation of Akt-GSK3β signal pathway.

Key words: Baicalin, Oxidative stress, Apoptosis, Gingival epithelial cells, Periodontitis

CLC Number: 

  • R781.4

Figure 1

H2O2-induced apoptosis in gingival epithelial cells"

Figure 2

Baicalin inhibited H2O2-induced apoptosis in gingival epithelial cells"

Figure 3

Baicalin -induced anti-apoptotic effect through Akt-GSK3β signaling"

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