Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (2): 124-127.doi: 10.12016/j.issn.2096-1456.2018.02.012

• Review Articles • Previous Articles     Next Articles

Research progress on osteoinductive properties of bone substitute materials

Jun HE1(), Ziliang LI1, Zhigang XIE2()   

  1. 1. Qianxing Road Dental Clinic, Affiliated Stomatology Hospital of Kunming Medical University, Kunming 650000, China
    2. Department of Implantation and Prosthodontics, Affiliated Stomatological Hospital of Kunming Medical University, Kunming 650000, China
  • Received:2017-02-17 Revised:2017-06-17 Online:2018-02-20 Published:2018-08-31

Abstract:

Bone graft material is not only a simple scaffold frame, but also a material with the potential to induce cells grow and differentiate into osteoblasts. The material with excellent bone induction properties can accelerate the healing of bone defect, thus repair the large area of bone defect successfully. Currently, plenty of researches regarding the bone induction in bone graft material have been reported, how to maximize the material osteoinductive potential, and to take advantage of these biological materials to produce the next generation of innovative biological material, is the current concerns. In this paper, a review is made on the bone induction properties of several kinds of bone substitutes.

Key words: Bone biomaterials, Osteoinductivity, Tissue engineering, Bone regeneration, Ectopic bone formation

CLC Number: 

  • R783.1
[1] Urist MR.Bone: formation by autoinduction[J]. Science, 1965, 150(3698): 893-899.
[2] 陈平. 不同方法制备的DDM异位成骨的实验研究[D]. 昆明: 昆明医科大学, 2013.
[3] 张鸣, 李翔. 脱钙骨基质的临床应用与研究进展[J]. 医学综述, 2013(14): 2540-2543.
[4] Liu Q, Ma Y, Wang J, et al.Demineralized bone matrix used for direct pulp capping in rats[J]. PLoS One, 2017, 12(3): e172693.
[5] 叶蜀新, 谢小平, 江伟, 等. 脱钙牙基质在骨修复中的应用[J]. 中国修复重建外科杂志, 2002, 16(05): 348-350.
[6] Karfeld-Sulzer LS, Weber FE.Biomaterial development for oral and maxillofacial bone regeneration[J]. J Korean Assoc Oral Maxillofac Surg, 2012, 38(5): 264.
[7] Kim Y, Lee J, Um I, et al.Tooth-derived bone graft material[J]. J Korean Assoc Oral Maxillofac Surg, 2013, 39(3): 103-111.
[8] Liu G, Xu G, Gao Z, et al.Demineralized dentin matrix induces odontoblastic differentiation of dental pulp stem cells[J]. Cells Tissues Organs, 2016, 201(1): 65-76.
[9] Koga T, Minamizato T, Kawai Y, et al.Bone regeneration using dentin matrix depends on the degree of demineralization and particle size[J]. PLoS One, 2016,11(1):e147235.
[10] 杨胜银. 脱矿牙本质基质骨诱导性及相关细胞鉴定的实验研究[D]. 昆明: 昆明医科大学, 2014.
[11] 熊航. DDM异位成骨过程中BMP-2表达的实验研究[D]. 昆明: 昆明医科大学, 2015.
[12] Kim Y, Lee J, Um I, et al.Guided bone regeneration using demineralized dentin matrix: long-term follow-up[J]. J Oral Maxillofac Surg, 2016, 74(3): 511-515.
[13] Kim ES.Autogenous fresh demineralized tooth graft prepared at chairside for dental implant[J]. Maxillofac Plast Reconstr Surg, 2015, 37(1): 8.
[14] Tansik G, Kilic E, Beter M, et al.A glycosaminoglycan mimetic peptide nanofiber gel as an osteoinductive scaffold[J]. Biomater Sci, 2016, 4(9): 1328-1339.
[15] Danmark S, Finne-Wistrand A, Albertsson AC, et al.Integrin-mediated adhesion of human mesenchymal stem cells to extracellular matrix proteins adsorbed to polymer surfaces[J]. Biomed Mater, 2012, 7(3): 35011.
[16] Winter GD.Heterotopic bone formation in a synthetic sponge[J]. Proc R Soc Med, 1970, 63(11 Pt 1): 1111.
[17] Isama K, Tsuchiya T.Enhancing effect of poly (L-lactide) on the differentiation of mouse osteoblast-like MC3T3-E1 cells[J]. Biomaterials, 2003, 24(19): 3303-3309.
[18] Kohn DH, Sarmadi M, Helman JI, et al.Effects of pH on human bone marrow stromal cells in vitro: implications for tissue engineering of bone[J]. J Biomed Mater Res, 2002, 60(2): 292-299.
[19] Cheng H, Jiang W, Phillips FM, et al. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)[J]. J Bone Joint Surg Am, 2003, 85-A(8): 1544-1552.
[20] Fujibayashi S, Neo M, Kim H, et al.Osteoinduction of porous bioactive titanium metal[J]. Biomaterials, 2004, 25(3): 443-450.
[21] Elganzoury I, Bassiony AA.Early results of trabecular metal augment for acetabular reconstruction in revision hip arthroplasty[J]. Acta Orthop Belg, 2013, 79(5): 530-535.
[22] Molicnik A, Hanc M, Recnik G, et al.Porous tantalum shells and augments for acetabular cup revisions[J]. Eur J Orthop Surg Traumatol, 2014, 24(6): 911-917.
[23] Wang N, Li H, Wang J, et al.Study on the anticorrosion, biocompatibility, and osteoinductivity of tantalum decorated with tantalum oxide nanotube array films[J]. ACS Appl Mater Interfaces, 2012, 4(9): 4516-4523.
[24] Danoux CB, Barbieri D, Yuan H, et al.In vitro and in vivo bioactivity assessment of a polylactic acid/hydroxyapatite composite for bone regeneration[J]. Biomatter, 2014, 4(1): e27664.
[25] 郭毅, 周磊, 谢建雅. 氟化物Y500R珊瑚骨羟基磷灰石复合人工骨在兔颅面成骨效应的实验研究[J]. 口腔疾病防治, 2016, 24(12): 695-700.
[26] 贾赛雄, 杜水红, 欧春培, 等. Bio-Oss骨粉复合BMP-2及VEGF修复大鼠胫骨缺损的实验研究[J]. 临床和实验医学杂志, 2015, 14(5): 349-352.
[27] 吴珍珍, 包崇云, 李明政, 等. 载有人胚胎干细胞的多孔磷酸钙骨水泥与富血小板血浆复合后修复大鼠骨缺损的实验研究[J]. 中国口腔颌面外科杂志, 2017(1): 6-10.
[28] Miron RJ, Zhang YF.Osteoinduction: a review of old concepts with new standards[J]. J Dent Res, 2012, 91(8): 736-744.
[1] CHEN Zetao,LIN Yixiong,YANG Jieting,HUANG Baoxin,CHEN Zhuofan. Research and development concept of barrier membranes based on “ immune microenvironment regulation” [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(8): 505-514.
[2] ZUO Xinhui,LI Jun,HAN Xiangzhen,LIU Xiaoyuan,HE Huiyu. Effects of hypoxia inducible factor-1α on osteogenic differentiation and angiogenesis related factors of bone marrow mesenchymal stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(7): 449-455.
[3] XU Xiaohang,XU Wanqiu,YAO Lihong,WANG Xiumei. Research progress on dental pulp stem cells in the repair of peripheral nerve injury [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(7): 500-504.
[4] LI Tianle,CHANG Xinnan,QIU Xutong,FU Di,ZHANG Tao. Effect of mechanical stimulation on the differentiation of stem cells in periodontal bone tissue engineering [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(4): 273-278.
[5] TAN Guozhong,JIANG Qianzhou. Applications and prospects of 3D printing technology in pulp regeneration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(4): 279-283.
[6] YAN Shanyu,MEI Hongxiang,LI Juan. Role of mesenchymal stem cells migration in bone injury repair [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(12): 854-858.
[7] SUN Jingxuan,LI Yanping,PAN Shuang,HE Lina,SUN Xiangyu,ZHANG Shuang,NIU Yumei. Effects of graphene on the proliferation, migration and morphology of dental pulp stem cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(10): 656-662.
[8] BIN Zhiwen,WANG Fang,HOU Jinsong. Research progress on the reconstruction of mandibular defects in adolescents [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(10): 711-715.
[9] XU Hongwei,HAN Bing. Research progress in mechanical strength enhancement methods of jaw tissue engineering scaffolds [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(9): 600-606.
[10] HE Mengjiao,LI Lisheng,CHEN Yuling,LUO Kai. Research progress on cell sheet technology and its application in periodontal tissue regeneration [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(7): 458-462.
[11] XIAO Wenlan,HU Chen,RONG Sheng′an,QU Yili. Clinical application of autogenous dentin as a bone graft material [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(6): 394-398.
[12] REN Lizhi,SUN Rui. New progress in the clinical application of GBR membrane materials [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(6): 404-408.
[13] WANG Yamin,ZHOU Zhen,DAO Junfeng,CHEN Qiyue,LIU Wenjing,SONG Guangbao. Evaluation of the effect of concentrated growth factor in guided bone regeneration in maxillary anterior tooth defects [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(4): 236-240.
[14] LIU Huimin,LI Xiangwei. Research progress of scaffolds for promoting the vascularization of regenerated dental pulp [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(3): 200-204.
[15] XIAO Wenlan,HU Chen,RONG Shengan,ZHU Chenyou,WU Yingying. Application of dentin in bone tissue engineering [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(2): 127-130.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] ZHU Song-song, HU Jing. The application of distraction osteogenesis in the temporomandibular joint ankylosis and secondary dentofacial deformities[J]. journal1, 2016, 24(1): 6 -10 .
[2] XU Jing. The influence of the impacted mandibular third molar extraction on the distal periodontal tissue of the mandibular second molar[J]. journal1, 2016, 24(1): 11 -14 .
[3] ZHONG Jiang-long, PAN Ji-yang, CHEN Wei-liang. The evaluation of Eagle syndrome treatment by surgery combined with antidepressant therapy[J]. journal1, 2016, 24(1): 26 -28 .
[4] CHEN Xi, SUN Qin-zhou. The study of colorimetric board of porcelain fused to metal restoration for moderate to severe dental fluorosis[J]. journal1, 2016, 24(1): 33 -36 .
[5] OUYANG Ke-xiong1, LIANG Jun, ZOU Rui, LI Zhi-qiang, BAI Zhi-bao, PIAO Zheng-guo, ZHAO Jian-Jiang.. Ion Torrent RNA-Seq detection and analysis of the long non-coding RNA in tongue squamous cell carcinoma[J]. journal1, 2016, 24(1): 15 -19 .
[6] YU Pei, XUE Jing, ZHANG Xiao-wei, ZHENG Cang-shang. The influence of the roughness of zirconia ceramic surface on microbial attachment[J]. journal1, 2016, 24(1): 20 -25 .
[7] LIU Fang. Clinical assessment of two fissure sealant techniques in children’s dental caries prevention[J]. journal1, 2016, 24(1): 44 -45 .
[8] . [J]. journal1, 2016, 24(1): 49 -52 .
[9] LU Jian-rong, BAN Hua-jie, WANG Dai-you, ZHOU Hui-hui, LONG Ru, QIN Shu-hua. Clinical observation of sternocleidomastoid muscle flaps combined with artificial biological membrane reparing the defects after parotidectomy[J]. journal1, 2016, 24(1): 29 -32 .
[10] LI Bin, HE Xiao-ning, GAO Yuan, HU Yu-ping. Clinical analysis of pain after two kinds of apical stop preparation[J]. journal1, 2016, 24(1): 40 -43 .
This work is licensed under a Creative Commons Attribution 3.0 License.