Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (4): 236-239.doi: 10.12016/j.issn.2096-1456.2018.04.007

• Cinical Study • Previous Articles     Next Articles

Study of event-related potentials in school-age children with cleft palate

Huang SHU1(), Feng YANG1, Ji WANG1, Yuhan XIAO3, Guicong DING1   

  1. 1. Department of Stomatology Shenzhen Children??s Hospital Shenzhen 518026 China
    2. Department of Speech Therapy Shenzhen Children??s Hospital Shenzhen 518026 China
    3. Evoked Potentials Laboratory Shenzhen Children??s Hospital Shenzhen 518026 China
  • Received:2017-09-02 Revised:2017-10-17 Online:2018-04-20 Published:2018-08-31

Abstract:

Objective To investigate possible functional disorders of central auditory processing and language in school-age children with cleft palate through an assessment of the characteristics of the P300 and N400 event-related potentials (ERPs). Methods This study included 28 school-age children with cleft palate, aged 6 to 12 years, and 30 children without cleft palate as a control group. The P300 and N400 ERPs were selected as indexes of the central auditory processing and language functions of children in both groups. The data were statistically compared between the two groups. Results Compared with the controls, the children with cleft palate showed a significantly prolonged P300 latency (331.73 ± 14.94 ms vs. 348.64 ± 14.66 ms, P < 0.05) and a significantly decreased P300 amplitude (13.47 ± 2.24 μV vs. 12.07 ± 2.46 μV, P < 0.05). Similarly, the N400 latency of children with cleft palate was significantly prolonged compared to that of controls (431.07 ± 17.90 ms vs. 408.23 ± 18.04 ms, P < 0.05), and the N400 amplitude was significantly decreased compared to that of controls (13.75 ± 2.12 μV vs. 15.17 ± 2.34 μV, P < 0.05). Conclusion School-age children with cleft palate may have central auditory processing disorders and language dysfunctions.

Key words: Cleft palate, School-age children, Event-related potential, Central auditory processing disorder, Language dysfunction

Table 1

Comparison of the P300 event-related potential between children with cleft palate and children without cleft palate\(\overline{x}\) ± s"

组别 P300
潜伏期(ms) 波幅(μV)
腭裂组 348.64 ± 14.66 12.07 ± 2.46
对照组 331.73 ± 14.94 13.47 ± 2.24
t 4.346 -2.259
P < 0.001 0.028

Figure 1

Diagram of the P300 and N400 event-related potentials of children with cleft palate and children without cleft palate"

Table 2

Comparison of the N400 event-related potential between children with cleft palate and children without cleft Palate \(overline{x}\)± s"

组别 N400
潜伏期(ms) 波幅(μV)
腭裂组 431.07 ± 17.90 13.75 ± 2.12
对照组 408.23 ± 18.04 15.17 ± 2.34
t 4.835 -2.414
P < 0.001 0.019
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