Abstract:

Periodontal disease is a common and frequently occurring oral disease, with numerous investigations on periodontitis etiology and treatment. The development of periodontal disease is affected by many factors, including local stimulation and systemic risk factors, and dental plaque biofilm is regarded as an initial factor. The molecular mechanisms of how dental plaque biofilm and other risk factors regulate the development of periodontal disease remain unclear. Autophagy is a ubiquitous self-regulating mechanism of eukaryotes and a process of cell self-phagocytosis and digestion. Autophagy is a complex process, involving a variety of cellular and tissue activities, including cellular stress, clearance of endogenous and exogenous cellular components, development, aging and cancer. Recent studies have shown that autophagy is closely related to inflammation. This paper addresses recent research advances in understanding the correlations between periodontal disease and autophagy to provide a reference in the study of new methods to treat periodontal disease from the perspective of autophagy in the future.

Key words: Periodontal disease, Etiology, Cell, Autophagy, Dental plaque biofilm, Tobacco smoking, Treatment

摘要：

牙周病是口腔疾病中的常见病、多发病，其病因学及治疗方法的研究一直倍受关注。牙周病的发生发展受多种致病因素影响，以牙菌斑生物膜为始动因子，受其他局部刺激因素和全身因素共同调控。其中牙周致病菌如何破坏牙周组织及危险因素在牙周病进程中发挥作用的分子机制仍不明确。自噬是真核生物普遍存在的自我调节机制，是细胞自体吞噬、消化的代谢过程。自噬涉及多种细胞和组织活动，包括细胞应激、内源性和外源性细胞成分清除、发育、衰老和癌症。近期研究表明，自噬与炎症反应之间存在密切联系。本文对牙周病与自噬相关性的研究进展进行简要综述，为进一步研究从自噬角度治疗牙周病的新方法提供参考。

关键词: 牙周病, 病因, 细胞, 自噬, 菌斑微生物, 吸烟, 治疗