Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (5): 325-329.doi: 10.12016/j.issn.2096-1456.2018.05.009

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Progress in the combined application of bone morphogenetic protein-2 and basic fibroblast growth factor in bone tissue engineering

Weimin LIN(), Miao CHEN, Chen HU, Yili QU()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-11-17 Revised:2017-12-03 Online:2018-05-20 Published:2018-08-30

Abstract:

Bone morphogenetic protein-2 (BMP-2) and basic fibroblast growth factor (bFGF) are two important signaling molecules for natural bone repair that are widely applied in the field of bone tissue engineering. BMP-2 accelerates the maturation and mineralization of osteoblasts, and bFGF exhibits significant effects on the promotion of cell division and angiogenesis. The osteogenesis mechanism of BMP-2 differs from that of bFGF, leading to a potentially complementary role between the two proteins. The use of a suitable dose of bFGF in combination with BMP-2 in bone tissue engineering synergistically promotes the formation of new bone and exhibits a better repair effect than either single growth factor. However, the suitable dose range of BMP-2 and bFGF in combination should be further clarified. The mechanism of the synergism and antagonism between BMP-2 and bFGF must be further delineated, and a drug delivery system that better simulates the growth factor release pattern during natural bone repair remains to be designed.

Key words: Bone morphogenetic protein-2, Basic fibroblast growth factor, Growth factors, Combined application, Bone tissue engineering, Bone regeneration

CLC Number: 

  • R781.5

Figure 1

Signaling pathways and interactions of BMP-2/bFGF in osteogenic differentiation"

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