Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (5): 338-340.doi: 10.12016/j.issn.2096-1456.2018.05.012

• Review Articles • Previous Articles    

Progress in research on connexin 43 in oral squamous cell carcinoma

Lijuan ZHOU(), Siming XIE()   

  1. School of Stomatology, Jinan University, Guangzhou 510632, China
  • Received:2017-08-01 Revised:2017-08-17 Online:2018-05-20 Published:2018-08-30

Abstract:

Cell gap junctions are a universal form of cellular connection in animal tissue that mediate the exchange of information, energy and material between adjacent cells. Clinical studies have demonstrated that the abnormal expression of the connexin 43 (Cx43) gene is closely associated with carcinogenesis and tumor progression. The present study reviewed relevant studies concerning the association between abnormal expression of Cx43 and oral squamous cell carcinoma as well as communication abnormalities of cell gap junctions.

Key words: Oral squamous cell carcinoma, Cx43, Gap junction intercellular communication, Tongue squamous cell carcinoma, Phosphorylation

CLC Number: 

  • R739.8
[1] Leithe E, Sirnes S, Omori Y, et al.Downregulation of gap junctions in cancer cells[J]. Critical Reviews in Oncogenesis, 2006, 12(3/4): 225-256.
[2] Siegel RL, Miller KD, Jemal A.Cancer statistics[J]. JAMA, 2013, 310(9): 982.
[3] Siegel RL, Miller KD, Jemal A.Cancer statistics[J]. CA Cancer J Clin, 2015, 65(1):5-29.
[4] Goodenough DA. Paul DL.Gap junctions[J]. Cold Spring Harb Perspect Biol, 2009, 1(1): a002576.
[5] Solan JL, Lampe PD.Connexin43 phosphorylation: structural changes and biological effects[J]. Biochem J, 2009, 419(2): 261-272.
宋娟, 张汉东. 间隙连接蛋白43在口腔颌面部鳞癌组织及舌癌细胞株(Tca8113)中表达的研究[J]. 临床口腔医学杂志, 2012, 28(8):467-470.
[6] 王安训, 黄洪章. 间隙连接蛋白43在舌鳞状细胞癌中的表达及意义[J].癌症, 2001, 20(9): 948-951.
[7] 冯燕, 康晓洁, 黎春晖, 等.细胞角蛋白19和间隙连接蛋白43在4-亚基硝氧喹啉诱发大鼠舌黏膜癌变过程中表达的研究[J]. 华西口腔医学杂志, 2013, 31(3): 237-241.
[8] Xia J, Liu X, Tao X, et al.Expression of gap junctional protein connexin43 during 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis[J]. J Mol Histol, 2009, 40(3): 183-188.
[9] Brockmeyer P, Hemmerlein B, Jung K, et al.Connexin subtype expression during oral carcinogenesis: a pilot study in patients with oral squamous cell carcinoma[J]. Mol Clin Oncol, 2016, 4(2): 298-302.
[10] Brockmeyer P, Jung K, Perske C, et al.Membrane connexin 43 acts as an independent prognostic marker in oral squamous cell carcinoma[J]. Int J Oncol, 2014, 45(1): 273-81.
[11] 昌毓穗, 刘季春, 傅华群, 等. Ras-MAPK通路在食管癌中的研究进展[J]. 中国病理生理杂志, 2013, 29(2): 376-380.
[12] Salameh A, Krautblatter S, Karl S, et al.The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors[J]. Br J Pharmacol, 2009, 158(1): 198-208.
[13] 颜建英, 黄科华, 刘青闽, 等. 产妇子宫平滑肌组织中MAPK信号转导通路及CX43表达与产后出血关系的研究[J]. 实用妇产科杂志, 2012, 28(7): 565-570.
[14] 李业如, 庞祥媚, 李敏, 等. Cx43对脑胶质瘤C6细胞增殖的影响及机制[J]. 中国药理学通报, 2017, 33(7): 1008-1013.
[15] 次旦旺久, 林坤, 卢再鸣, 等. MAPK信号通路在肝癌发生发展及治疗中的作用[J]. 临床肝胆病杂志, 2016, 32(9): 1810-1813.
[16] Yang Y, Qin SK, Wu Q, et al.Connexin-dependent gap junction enhancement is involved in the synergistic effect of sorafenib and all-trans retinoic acid on HCC growth inhibition[J]. Oncol Rep, 2014, 31(2): 540-550.
[17] Ionta M, Rosa MC, Almeida RB, et al.Retinoic acid and cAMP inhibit rat hepatocellular carcinoma cell proliferation and enhance cell differentiation[J]. Brazilian J Med Biol Res, 2012, 45(8): 721-729.
[18] Shibata T, Nagayasu H, Hamada J, et al.Inhibitory effects of malotilate on in vitro invasion of lung endothelial cell monolayer by human oral squamous cell carcinoma cells[J]. Tumour Biol, 2000, 21(5): 299-308.
[19] Livny O, Kaplan I, Reifen R, et al.Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells[J]. J Nutri, 2002, 132(12): 3754-3759.
[20] Livny O, Kaplan I, Reifen R, et al.Oral cancer cells differ from normal oral epithelial cells in tissue like organization and in response to lycopene treatment: an organotypic cell culture study[J]. Nutrition & Cancer, 2003, 47(2): 195-209.
[21] 王安训, 黄洪章. 全反式维甲酸提高HSV-TK/GCV系统治疗舌鳞癌旁观者效应的研究[J].中华口腔医学杂志, 2003, 38(1): 24-26.
[22] Xiao B, Guo J, Lou Y, et al.Inhibition of growth and increase of alkaline phosphatase activity in cultured human oral cancer cells by all-trans retinoic acid[J]. Int J Oral Maxillofac Surg, 2006, 35(7):643-648.
[23] Kuroda J, Urade M, Kishimoto H, et al.Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells[J]. Int J Oncol, 2005, 26(2): 361.
[24] Siddikuzzaman, Guruvayoorappan C, Grace V M B. All Trans Retinoic Acid and Cancer[J]. Immunopharmacol Immunotoxicol, 2011, 33(2): 241-249.
[25] Meir GD, Joel B, Epstein D.The effect of retinoids on premalignant oral lesions[J]. Cancer, 2010, 95(6): 1258-1264.
[26] Wang J, Dai Y, Huang Y, et al.All-trans retinoic acid restores gap junctional intercellular communication between oral cancer cells with upregulation of Cx32 and Cx43 expressions in vitro[J]. Medicina Oral Patologia Oral Y Cirugia Bucal, 2013, 18(4): 569-577.
[1] ZENG Fantao,YU Dongsheng. Knockdown of circ_0001273 inhibits the proliferation, migration and invasion of oral squamous cell carcinoma cells [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(3): 153-157.
[2] Xinyu LIN,Weixiong CHEN,Xinyuan LEI,Zhanpeng OU,song FAN,Jinsong LI. Screening and identification of mitochondrial miRNAs related to chemotherapy resistance in tongue squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(7): 417-422.
[3] Xinyuan LEI,Xinyu LIN,Zhanpeng OU,Yi RUAN,Jinsong LI. Mitochondrial fission protein 1 determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(6): 350-354.
[4] LIN Lin,DUAN Ning,WANG Xiang,JIANG Hongliu,WANG Wenmei. Oral verrucous xanthoma in adolescents: a case report and literature review [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(5): 318-320.
[5] WANG Anxun. Abnormal glucose and lipid metabolism and oral squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(3): 137-142.
[6] TIAN Yuanye,TANG Zhangui. Research progress on the CD4 +T cell balance in oral cancer and precancerous diseases [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(2): 115-121.
[7] ZENG Sujuan,PENG Bo,CHENG Weidong,WEI Dongfeng,HUANG Wenyan,LI Yunyang,ZHAO Wanghong. Experimental study on the effect of hedysarum polybotys saccharides and selenizated hedysarum polybotys saccharides on oral squamous cancer cells in vitro [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(12): 757-762.
[8] HUANG Lihuan,JIANG Yingtong,OUYANG Kexiong,WU Lihong,YANG Xuechao. Research progress on the role and mechanism of miR-155 in the development of oral squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(12): 809-812.
[9] Chaobin PAN. Research progress in comprehensive and sequential treatment of tongue squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(5): 273-280.
[10] Wenfeng GAO,Zhiping WANG,Jing XU,Zhifeng SONG,Shuguang ZENG. Significance of the levels of Twist and Vimentin proteins in oral squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(10): 639-643.
[11] Laiping ZHONG,Wutong JU. Progress of translational research on biomarker-based oral squamous cell carcinoma treatment [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(10): 621-626.
[12] Ya-nan WANG, Hao LIU, Jun ZHANG. Expression of autophagy-related proteins PTEN and MAP1LC3 in tongue squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(5): 294-299.
[13] Yan-fei CHENG,Yong-rong ZHONG. Study of the cellular growth inhibited by tetrandrine with the expression of β-catenin in oral squamous cell carcinoma cell line [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(8): 464-468.
[14] Jia-peng LIU,Zhen WANG,Si-ming XIE. Research progress of Nme gene family and its application in oral squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(7): 437-440.
[15] Xiao-zhi LÜ,Ting-ru SHAO,Meng ZHAO. Reconstruction of defects with supraclavicular artery island flap following ablation of tongue squamous cell carcinoma [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(7): 386-389.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Chao TANG,Jing SUN,Ju-feng CHEN. Influence of nursing intervention on the life quality of patients with tongue cancer after operation[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(3): 177 -179 .
[2] Hong-chang LAI,Jun-yu SHI. Maxillary sinus floor elevation[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(1): 8 -12 .
[3] WANG An-xun. Research progress on the invasion and metastasis of tongue squamous cell carcinoma[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(5): 261 -266 .
[4] Pin ZHOU, Yang-fei LI. MRI study of temporomandibular joint disc position in asymptomatic volunteers[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(4): 239 -244 .
[5] Xinxin XIA, Fang FANG, Lijuan CHENG. Shaping ability of Pathfile and WaveOne in simulated root canals[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(6): 365 -368 .
[6] Yuanhong LI, Xinyi FANG, Yu QIU, Lei CHENG. Experimental study on the effects of green tea on salivary flow rate and pH value[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(9): 560 -564 .
[7] Chengzhang LI. Masticatory muscles in occlusion[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(12): 755 -760 .
[8] . [J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(1): 1 .
[9] Zhirong WU, Shiguang Huang. Research progress on the etiology, clinical examination and treatment of peri-implantitis[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(6): 401 -405 .
[10] Xiaowu YAO, Shisheng CHEN, Zizheng LU, Minxiao LIN. Clinical report and literature review on the amyloidosis of salivary glands[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(8): 533 -536 .
This work is licensed under a Creative Commons Attribution 3.0 License.