Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (6): 374-378.doi: 10.12016/j.issn.2096-1456.2018.06.007

• Cinical Study • Previous Articles     Next Articles

Treatment of oral submucous fibrosis with local injection of salvia miltiorrhiza combined with triamcinolone acetonide: a meta-analysis

Xinjia CAI(), Junhui HUANG(), Zhigang YAO, Long LI, Gui LIU, Junjie LIU, Huiling LI, Lin CUI   

  1. Department of Oral Pathology, Xiangya Stomatological Hospital, Central South University, Changsha 410078, China
  • Received:2017-12-18 Revised:2018-01-10 Online:2018-06-20 Published:2018-08-30

Abstract:

Objective To evaluate the efficacy of the local injection of Salvia miltiorrhiza combined with triamcinolone acetonide and triamcinolone acetonide alone in the treatment of oral submucous fibrosis (OSF). Methods A meta-analysis was performed by searching the related literature. Three randomized controlled trials meeting the inclusion criteria were identified. Changes in the Visual Analogue Scale (VAS) score and the degree of mouth opening were included in 172 cases (86 cases in the experimental group and 86 in the control group), and changes in the oral mucosal lesion area were included in 152 cases (76 cases in the experimental group and 76 in the control group). Changes in the VAS score, the degree of mouth opening and the oral mucosal lesion area were compared in the context of the local injection of Salvia miltiorrhiza combined with triamcinolone acetonide and triamcinolone acetonide alone. Results There were no significant differences between the treatment with Salvia miltiorrhiza combined with triamcinolone acetonide and triamcinolone acetonide alone in reducing the VAS score (P > 0.05). Salvia miltiorrhiza combined with triamcinolone acetonide resulted in a greater increase in the degree of mouth opening than did triamcinolone acetonide (P = 0.05). The reduction in the oral mucosal lesion area induced by Salvia miltiorrhiza combined with triamcinolone acetonide was significantly greater than that induced by triamcinolone acetonide alone (P < 0.05). Conclusion The local injection of Salvia miltiorrhiza combined with triamcinolone acetonide is more effective than triamcinolone acetonide alone in the treatment of OSF.

Key words: Oral submucosal fibrosis, Meta-analysis, Salvia miltiorrhiza, Triamcinolone acetonide

CLC Number: 

  • R781.5

Figure 1

Search strategy"

Table 1

Comparison of VAS score, degree of mouth opening and oral mucosa lesion area \(\overline{x}\) ± s"

作者 组别 病例数 VAS评分(分) 张口度(mm) 黏膜病损面积(cm2
治疗前 治疗后 治疗前 治疗后 治疗前 治疗后
吕逢源等[9] 丹参+曲安奈德 10 6.60 ± 2.17 3.80 ± 2.10 25.6 ± 7.2 30.1 ± 6.9 - -
曲安奈德 10 7.10 ± 1.97 3.80 ± 2.57 27.0 ± 7.3 31.4 ± 8.1 - -
薛洪权等[10] 丹参+曲安奈德 41 4.75 ± 1.12 3.18 ± 0.12 29.06 ± 6.22 37.12 ± 4.95 8.83 ± 0.52 5.25 ± 0.56
曲安奈德 41 4.92 ± 1.21 3.95 ± 0.86 28.89 ± 7.51 32.51 ± 6.45 8.81 ± 0.56 6.53 ± 0.57
赵雁焕等[11] 丹参+曲安奈德 35 2.42 ± 0.56 0.88 ± 0.36 24.8 ± 11.2 38.4 ± 12.4 15.25 ± 4.46 7.56 ± 2.31
曲安奈德 35 2.38 ± 0.71 0.91 ± 0.42 25.1 ± 11.7 27.5 ± 11.4 15.21 ± 4.52 10.71 ± 3.16

Figure 2

Results of the meta-analysis and quality assessment"

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