Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (7): 456-459.doi: 10.12016/j.issn.2096-1456.2018.07.009

• Cinical Study • Previous Articles     Next Articles

Clinical value of serum markers of type 2 diabetes mellitus complicated by chronic periodontitis

Peisen LI1(), He LI2, Qiujuan LIANG2, Yan LI2()   

  1. 1. Xinjiang Medical University, Urumqi 830054, China
    2. Department of Stomatology, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830023, China.
  • Received:2017-11-04 Revised:2018-01-27 Online:2018-07-20 Published:2018-08-30

Abstract:

Objective To investigate the relation between serum markers, the degree of lesions and the active period of chronic periodontitis in patients with type 2 diabetes mellitus. Methods A total of 595 patients with type 2 diabetes mellitus were selected, and oral examinations and laboratory tests were conducted. The patients were divided into a periodontally healthy group mild, moderate and severe periodontitis groups depending on the diagnostic criteria for chronic periodontitis. The patients were also divided into periodontally healthy, resting and active groups depending on the diagnostic criteria of the active period. The relationships between serum biochemical indices, the degree of lesions and chronic periodontitis activity were analyzed. Results The prevalence of chronic periodontitis in patients with type 2 diabetes was 74.6%, and the proportions of patients with mild, moderate, and severe chronic periodontitis were 44.9%, 16.1% and 13.6%, respectively. The composite ratio of active periodontal chronic periodontitis was 33.1%. Compared with the patients in the control group, the fasting plasma glucose and HbA1c levels were more poorly controlled in the type 2 diabetes mellitus groups with chronic periodontitis (P < 0.05). There were significant differences in fasting blood glucose levels between mild periodontitis group and moderate, severe periodontitis group (P < 0.05). There was no significant difference in HbA1c levels among the mild, moderate and severe groups (P>0.05). However, there were significant differences in fasting blood glucose levels between the groups with various degrees of progression in the following order: active (11.24 mmol /L) > resting (9.64 mmol/L) > control (8.82 mmol/L) (P < 0.05). Conclusion The severity of chronic periodontitis plays no role in the level of HbA1c, instead, the level of fasting plasma glucose changes with the severity and progression of chronic periodontitis.

Key words: Type 2 diabetes mellitus, Chronic periodontitis, Degree of lesions, Active period

CLC Number: 

  • R781.4

Table 1

Distribution of chronic periodontitis prevalence in T2DM patients in various groups"

分组 对照组
n = 151)
牙周炎组
n = 444)
t值/
χ2
P
年龄 56.39 ± 11.41 59.00 ± 11.50 -2.411 0.016
糖尿病病程 7.48 ± 6.60 7.91 ± 7.16 -0.658 0.511
性别 88 275 0.634 0.426
63 169
吸烟 55 186 1.398 0.237
96 258
FPG 正常组(<6.1 mmol/L) 20 25 9.545 0.003
超标组(≥6.1 mmol/L) 131 419
PPG 正常组(<11.1 mmol/L) 41 103 0.960 0.327
超标组(≥11.1 mmol/L) 110 341
HbA1c 正常组(<7 mmol/L) 35 56 29.549 <0.001
一般组(7~8 mmol/L) 47 76
欠佳组(≥8 mmol/L) 69 312
TG 正常组(<1.7 mmol/L) 76 234 0.254 0.614
超标组(≥1.7 mmol/L) 75 210
TC 正常组(<5.7 mmol/L) 136 408 0.479 0.489
超标组(≥5.7 mmol/L) 15 36

Table 2

Comparison of serum markers in the control, mild, moderate and severe groups $\bar{x}$±s"

变量 对照组
(151人)
轻度组
(267人)
中度组
(96人)
重度组
(81人)
F P P1 P2 P3 P4 P5 P6
FPG 8.82 ± 3.083 10.01 ± 3.487 10.82 ± 3.544 10.91 ± 3.612 9.751 < 0.001 <0.01 <0.01 <0.01 <0.05 <0.05 >0.05
PPG 14.05 ± 4.623 14.68 ± 5.367 15.63 ± 5.515 15.47 ± 5.139 2.364 0.070
HbA1c 8.14 ± 1.768 9.68 ± 2.584 9.91 ± 2.452 9.85 ± 2.426 18.136 < 0.001 <0.01 <0.01 <0.01 >0.05 >0.05 >0.05
TG 2.12 ± 1.606 2.03 ± 1.497 1.94 ± 1.510 1.92 ± 1.004 0.438 0.726
TC 4.27 ± 1.140 4.27 ± 1.089 4.29 ± 1.253 4.28 ± 0.997 0.017 0.997

Table 3

Comparison of serum markers in the control, quiescent and active groups $\bar{x}$±s"

变量 对照组(151人) 静止期组(247人) 活动期组(197人) F P P1 P2 P3
FPG 8.82 ± 3.083 9.64 ± 3.420 11.24 ± 3.498 24.051 < 0.001 <0.01 <0.05 <0.01
PPG 14.05 ± 4.623 14.82 ± 5.313 15.29 ± 5.430 2.458 0.086
HbA1c 8.14 ± 1.768 9.61 ± 2.333 9.95 ± 2.739 28.035 < 0.001 <0.01 <0.01 >0.05
TG 2.12 ± 1.606 2.03 ± 1.659 1.96 ± 1.053 0.539 0.584
TC 4.27 ± 1.140 4.27 ± 1.092 4.29 ± 1.131 0.019 0.981
[1] Jepsen S, Springer IN, Buschmann A, et al.Elevated levels of collagen cross-link residues in gingival tissues and crevicular fluid of teeth with periodontal disease[J]. Eur J Oral Sci, 2003, 111(3): 198-202.
[2] Hong M, Yeon KH, Hannah S, et al.Prevalence and risk factors of periodontitis among adults with or without diabetes mellitus[J]. Korea J Int Med, 2016, 31(5): 910-919.
[3] Nazir MA.Prevalence of periodontal disease, its association with systemic diseases and prevention[J]. Int J Health Sci, 2017, 11(2): 72-80.
[4] Chapple IC, Genco R.Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases[J]. J Periodontol, 2013, 40(Suppl 14): S106-112.
[5] 钱荣立. 关于糖尿病的新诊断标准与分型[J]. 中国糖尿病杂志, 2000, 8(1): 4-5.
[6] 孟焕新. 牙周病学[M]. 4 版. 北京: 人民卫生出版社, 2012: 170.
[7] Newman MG, Takei H, Klokkevold PR, et al.Carranza′s clinical periondontology[M]. USA: Elsevier Inc, 2011: 135-136.
[8] Baelum V, Papapanou PN.CPITN and the epidemiology of periodontal disease[J]. Community Dent Oral Epidemiol, 1996, 24(6): 367-368.
[9] Lalla E, Lamster IB.Assessment and management of patients with diabetes mellitus in the dental office[J]. Dent Clin North Am, 2012, 56(4): 819-829.
[10] Gürsoy UK, Çiftlikli SY, Könönen E, et al.Salivary IL-17 and TNF-a in relation to periodontitis and glycemic status in type 2 diabetes mellitus[J]. J Diabetes, 2014, 10: 551-557.
[11] Costa KL, Taboza ZA, Angelino GB, et al.Influence of periodontal disease on changes of glycated hemoglobin levels in patients with type 2 diabetes mellitus: a retrospective cohort study[J]. J Periodontol, 2017, 88(1): 17-25.
[12] Zhou X, Zhang W, Liu X, et al.Interrelationship between diabetes and periodontitis: role of hyperlipidemia[J]. Arch Oral Biol, 2015, 60(4): 667-674.
[13] Silva N, Dutzan N, Hernandez M, et al.Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells[J]. J Clin Periodontol, 2008, 35(3): 206-214.
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