Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (9): 601-605.doi: 10.12016/j.issn.2096-1456.2018.09.011

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Relationship between T cells and bone regeneration: recent progress and perspectives

Renli YANG1,2,Yuanjing WANG1,Shimin WEI1,Wen HUANG1,Yufei WANG1,3,Chenyou ZHU1,2,Yili QU1,2   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China
    2. Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    3. Dept. of Endodontics, West China Hospital of Stomatology, Sichuan University
  • Received:2018-06-29 Revised:2018-07-27 Online:2018-09-20 Published:2018-09-30

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Abstract:

Bone is capable of regeneration after injury, but the process of properly restoring form and function is highly complex and prone to failure. The restoration process requires highly ordered and sequential interplay at the injury site between the host immune system and bone tissue. The dynamic process that occurs after bone injury includes the formation of a hematoma, the development of an inflammatory response and callus, and the remodeling of newly formed bone tissue. The inflammatory response at the injury site is essential for the onset of bone regeneration. This inflammatory response is tightly linked with the host immune system, in which various immune cells and molecules are involved. Recently, the relationship between T cells and bone regeneration has become a popular topic; however, currently, there are no summaries of the relationship between T cells and bone regeneration. Thus, this review aimed to elucidate the modulatory functions of T cells in bone regeneration.

Key words: T cells, Subsets, Bone regeneration, Regulatory T cells, Cytokine, Inflammation

CLC Number: 

  • R78

Figure 1

The relationship between T cell subsets and bone regeneration"

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