Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (9): 606-612.doi: 10.12016/j.issn.2096-1456.2018.09.012

• Review Articles • Previous Articles    

Research status of the relationship between periodontitis and systemic disease

Miaoying CHENG,Dan LIANG,Zhiqun TANG,Hongkun WU()   

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Geriatric Dentistry,West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-03-08 Revised:2018-03-31 Online:2018-09-20 Published:2018-09-30

Abstract:

Periodontitis is a common infectious disease that is harmful to human oral health and is the main cause of tooth loss. Periodontal inflammation can damage the integrity of the epithelium, causing periodontal pathogens to spread to the systemic circulation, and the periodontal pocket contains a large number of inflammatory mediators, especially those related to chronic inflammation, such as tumor necrosis factor-α, interleukins and prostaglandins, which will enter the blood circulation system from periodontal pocket and cause systemic inflammatory response. Periodontitis is closely related to the occurrence and development of systemic diseases, including cardiovascular, endocrine, respiratory, immune, and nervous systems. Inflammatory responses and inflammatory factors may be the mechanism of the association between periodontitis and multiple systemic diseases. This article reviews the current research on the relationship between periodontitis and systemic disease.

Key words: Periodontitis, Systemic disease, Inflammatory factors, Cardiovascular disease, Atherosclerosis, Type 2 diabetes, Chronic obstructive pulmonary disease, Inflammation

CLC Number: 

  • R781.4
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