Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (10): 613-620.DOI: 10.12016/j.issn.2096-1456.2018.10.001

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The effect of the osteoimmunomodulatory mechanism on implant osseointegration and bone biomaterials induced bone regeneration

Jiang CHEN1(),Xuxi CHEN2,Lin ZHOU1   

  1. 1. Department of Dental Implant, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou 350002, China
    2. School of Stomatology of Fujian Medical University, Fuzhou 350002, China
  • Received:2018-03-28 Revised:2018-04-18 Online:2018-10-20 Published:2018-10-20

骨免疫调节机制对种植体骨结合及骨生物材料引导骨再生的影响

陈江1(),陈旭晞2,周麟1   

  1. 1. 福建医科大学附属口腔医院种植科,福建 福州(350002)
    2. 福建医科大学口腔医学院, 福建 福州(350002);
  • 作者简介:陈江,教授,主任医师,博士生导师。于2000 年被国家留学基金委员会公派赴美国哈佛大学牙学院和塔夫茨大学新英格兰医学中心访问研究。现任福建医科大学口腔医学院及附属口腔医院院长,兼任中华口腔医学会常务理事、中华口腔医学会口腔种植专业委员会副主任委员、中华口腔医学会口腔肿瘤学组成员、福建省口腔医学会会长、福建省口腔医学会口腔种植专业委员会顾问、中国医师协会口腔医师分会维权组成员、国际口腔种植学会(ITI)专家组成员。国务院政府特殊津贴享受者,福建省百千万人才工程人选,福建医科大学学科带头人。主持国家自然基金、福建省发改委产业技术开发项目、福建省科技重大科研项目、福建省教育厅重点项目、福建省自然科学基金项目等科研课题 10 余项,获福建省科技进步二等奖 1 项,福建省医学科技三等奖 1项,新型实用与发明专利三项。主编、主译、参编学术专著 6部。
  • 基金资助:
    国家自然科学基金项目(81771126);福建省卫生计生委青年基金项目(2017-2-37)

Abstract:

With the development of implant dentistry and biomaterials, dental implants have become the first rehabilitative option proposed for the treatment of missing teeth. Most studies about dental implants and biomaterials currently focus on osteogenesis and the osseointegration of the implant, neglecting the importance of the immune response. In recent years, the development of osteoimmunology has been one of the greatest achievements in bone biomaterials; osteoimmunology has revealed the vital role of immune cells in regulating bone dynamics, implying the value of studies on materials with favorable osteoimmunomodulatory properties. This article reviews the integration between bone tissue and implants and summarizes the effects of the immune response during osseointegration and new bone formation to show the importance of regulating the immune response in this process. The effect of macrophages on osteogenesis and osteoclastogenesis is then reviewed due to the high plasticity and multiple roles of macrophages during this process. Accordingly, the interaction between the implants, the immune systems and the skeletal system is explained, showing the potential value of osteoimmunomodulation as a biological principle for developing bone biomaterials and new types of implants.

Key words: Bone immune regulation mechanism, Dental implants, Implant, Bone biomaterial, Bone formation, Inflammation, Surface modification

摘要:

随着口腔种植技术和骨生物材料的发展,种植牙已成为牙列缺损和牙列缺失的首选方案。围绕种植体和骨生物材料的研究主要集中于种植体骨结合和诱导成骨方面,而忽视了免疫反应在这一过程中的重要作用。近年来在骨生物材料领域,骨免疫学研究取得了巨大的成就,其揭示了免疫细胞在调节骨骼动力学方面的重要作用,展现了骨生物材料免疫调节性能方面的远大研究应用前景。本文首先回顾了种植体的骨结合机制,并着眼于免疫反应在骨结合和新骨形成过程中的重要作用从而展现了调节免疫反应在这一过程中的重要性。同时基于巨噬细胞高度的可塑性及其在免疫反应中的多重作用,着重探讨巨噬细胞对成骨、破骨细胞生成过程的重要影响。由此解释了种植体和骨生物材料、免疫系统及骨骼系统间的相互作用,阐明了骨免疫调节机制在新型种植体、骨生物材料设计和开发中存在的潜在价值。

关键词: 骨免疫调节机制, 口腔种植, 种植体, 骨生物材料, 骨形成, 骨结合, 炎症, 表面改性

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