Journal of Prevention and Treatment for Stomatological Diseases ›› 2018, Vol. 26 ›› Issue (10): 657-662.doi: 10.12016/j.issn.2096-1456.2018.10.009

• Prevention and Treatment Practice • Previous Articles     Next Articles

Oral health status in children with acute lymphoblastic leukemia

Guixia ZHOU1,Rui HAN2,Daizun ZHANG2,Wenjing HAO2,Xiaoyan XU2()   

  1. 1. Department of stomatology, Jining No.1 People′s Hospital, Jining 272011, China;
    2. Qingdao University School of Stomatology, Qingdao 266003, China
  • Received:2017-12-13 Revised:2018-03-12 Online:2018-10-20 Published:2018-10-20

Abstract:

Objective To provide basic data for the prevention of oral diseases in children with acute lymphoblastic leukemia (ALL) by investigating the oral health status.Methods Seventy-three children diagnosed with ALL and seventy-three healthy controls participated in the study. Oral examinations were carried out for both groups. The crown caries were analyzed by calculating the incidence of caries, mean caries and dental caries filling rate; the soft scale index (debris index, DI) and plaque index (plaque index, PLI) were used to record oral hygiene status; and the modified gingival index (modified gingival index, MGI) was used to record gingival health status. A questionnaire was given to the parents at the same time. The data were collected and analyzed with SPSS 20.0 software.Results ① The average numbers of decayed teeth in the observation and control groups were 1.34 ± 171 and 1.15 ± 1.67, respectively. The caries prevalence were 52.05% and 41.10%, but there was no significant difference between the two groups (P>0.05). The obturation rate of caries was 6.12% and 20.24%, and the difference between the two groups was significant (P = 0.001). ② The DI, PI and MGI of the observation group were higher than those in control group, and the differences were significant (P< 0.05). ③ There was a mean of 1.21 ± 1.70 caries in male children and 1.47 ± 1.75 in female children; there was no significant difference between the two groups (P>0.05). The< 6 years old group had a mean of 1.65 ± 1.92 caries and that of the 6~14 group was 0.71 ± 0.95; the difference was significant (P< 0.05). The urban group and rural group had means of 0.87 ± 1.31 and 1.69 ± 1.91 caries, respectively, and the difference was significant (P< 0.05). Children who brushed their teeth and strictly controlled their sweets had significantly fewer mean caries than did those who did not brush their teeth and ate more sweets, and the difference was statistically significant (P< 0.05). ④ The DI, PLI and MGI were significantly different between different age groups and different places of residence (P< 0.05).Conclusion The oral health status of children with ALL was poorer than that of normal children; oral hygiene was not maintained. Thus, more attention must be paid to the prevention and control of caries and periodontal diseases among children with ALL.

Key words: Acute lymphoblastic leukemia, Children, Oral health status, Questionnaire

CLC Number: 

  • R788

Table 1

The caries status of the children in the two groups"

分组 受检人数 患龋人数 患龋率(%) 龋均 龋、失、补牙数(颗) 龋齿充填牙数(颗) 龋齿充填率(%)
观察组 73 38 52.05 1.34 ± 1.71 98 6 6.12
对照组 73 30 41.10 1.15 ± 1.67 84 17 20.24
t值/χ2 1.762 0.684 8.163
P 0.184 0.495 0.001

Table 2

The oral hygiene and gingival status of the children in the two groups"

分组 人数 DI PLI MGI
0 1 2 3 0 1 2 3 0 1 2 3 4
观察组 73 4 27 31 11 4 28 26 15 12 31 16 9 5
对照组 73 15 33 20 5 16 37 12 8 35 25 11 2 0
Z -3.286 -3.749 -4.443
P < 0.01 <0.01 <0.01

Table 3

The caries status of the children with ALL"

因素 分组 人数(n 龋均 t P
性别 37 1.21 ± 1.70 -0.634 0.528
36 1.47 ± 1.75
年龄(岁) < 6 49 1.65 ± 1.92 -2.270 0.026
6~14 24 0.71 ± 0.95
居住地 31 0.87 ± 1.31 -2.060 0.043
42 1.69 ± 1.91
刷牙情况 不刷或不是每天都刷 48 1.71 ± 1.93 2.623 0.011
每天1次及以上 25 0.64 ± 0.86
睡前进食甜食情况 很少或从来不吃 52 0.94 ± 1.23 3.347 <0.001
经常进食甜食 21 2.33 ± 2.31
平常进食甜食情况 很少或从来不吃 68 1.12 ± 1.51 4.686 <0.001
经常进食甜食 5 4.44 ± 1.52

Table 4

The oral hygiene and gingival status of the children with ALL"

因素 分组 人数
n
DI PLI MGI
0 1 2 3 0 1 2 3 0 1 2 3 4
性别 37 2 13 15 7 1 15 12 9 5 17 9 6 2
36 2 14 16 4 3 13 14 6 7 14 7 3 3
Z -0.604 -0.597 -0.639
P 0.546 0.551 0.523
年龄 <6岁 49 0 13 26 10 1 16 20 12 3 20 15 7 4
6-14岁 24 4 14 5 1 3 12 6 3 9 11 1 2 1
Z -4.068 -2.334 -3.343
P <0.010 0.020 <0.010
居住地 31 3 15 12 1 2 16 10 3 8 16 5 1 1
42 1 12 19 10 2 12 16 12 4 15 11 8 4
Z -2.843 -2.283 -2.983
P 0.004 0.022 0.03
刷牙情况 刷牙 30 4 16 10 0 4 20 6 0 9 16 4 1 0
不刷牙 43 0 11 21 11 0 8 20 15 3 15 12 8 5
Z -4.112 -5.432 -3.927
P <0.010 <0.010 <0.010
牙线使用情况 用牙线 6 4 1 1 0 2 3 1 0 4 1 0 1 0
不用牙线 67 0 26 30 11 2 25 25 15 8 30 16 8 5
Z -3.166 -2.470 -2.194
P 0.020 0.014 0.028
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