Journal of Prevention and Treatment for Stomatological Diseases ›› 2019, Vol. 27 ›› Issue (1): 9-16.doi: 10.12016/j.issn.2096-1456.2019.01.003

• Expert Forum • Previous Articles     Next Articles

Current status and progress of periodontal regeneration therapy

Faming CHEN(),Lina GAO,Fang CHEN   

  1. State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases& Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi′an 710032, China
  • Received:2018-07-05 Revised:2018-08-26 Online:2019-01-20 Published:2019-01-22
  • Contact: Faming CHEN


Periodontitis is the most common oral disease and has a high incidence in humans. Periodontitis seriously affects the function of the oral and maxillofacial systems and is the most important cause of tooth loss in adults. In addition, as a long-term and persistent source of infection, periodontitis can not only trigger chronic inflammation and immune responses but also has an important impact on systemic health. Traditional periodontitis treatment focuses on inflammation control, and although this can prevent or delay the progression of the disease, satisfactory periodontal lesion tissue regeneration is difficult to obtain. With the introduction of new technologies and new materials such as guided tissue regeneration, bone grafting, growth factors and biological materials for the treatment of periodontitis, the method of periodontal tissue regeneration is more abundant, and the clinical effect has been greatly improved. In the future, stem cell transplantation and endogenous regeneration strategies are expected to become important methods for physiological and functional regeneration of periodontal lesions. This article briefly reviews the basic research and clinical application of periodontal tissue regeneration and forecasts the future development prospects and opportunities in this field.

Key words: Periodontitis, Guided tissue regeneration, Growth factors, Stem cell transplantation, Endogenous regeneration, Periodontal regeneration

CLC Number: 

  • R781.4

Table 1

Classification and characteristics of bone graft materials"

分类 来源 特性 缺点
自体骨 口腔内部 骨引导 可利用材料有限
口腔外部 骨诱导 可能需要二阶段手术
同种异体骨 新鲜冷冻骨 骨引导 不能完全排除传播疾病的可能性
冻干骨 骨诱导
异种骨 牛骨 骨引导 所有产品均不能排除传播疾病的可能性
珊瑚 吸收缓慢
骨替代品 聚合物 骨引导 吸收能力不同
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